With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1158759-03-5,tert-Butyl ((4-methylpiperidin-4-yl)methyl)carbamate,as a common compound, the synthetic route is as follows.
tert-Butyl (1-(6-chloro-5-(3-chloro-2-(methylamino)isonicotinoyl)pyrazine-2-yl)-4-methylpiperidin-4-yl)methyl carbamate To a solution of Intermediate 113 (63.2 mg, 0.2 mmol) in DMF (2 mL) under N2 was added tert-butyl (4-methylpiperidin-4-yl)methyl carbamate (45.6 mg, 0.2 mmol) and K2CO3 (55.3 mg, 0.4 mmol). The resulting mixture was stirred overnight at RT and poured into H2O (20 mL). The solid that formed was removed by filtration and dried to give the title compound as a yellow solid (120 mg) which was used directly without further purification. MS (ES+) C23H30C12N6O3 requires: 508, found: 509 [M+H]+.
1158759-03-5, 1158759-03-5 tert-Butyl ((4-methylpiperidin-4-yl)methyl)carbamate 70650847, apiperidines compound, is more and more widely used in various.
Reference£º
Patent; Board of Regents, The University of Texas System; JONES, Philip; CZAKO, Barbara; CROSS, Jason; LEONARD, Paul; MSEEH, Faika; PARKER, Connor Austin; (136 pag.)US2017/342078; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem