Tag: 114.1888

Lassoued, Mohamed Saber et al. published their research in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2022 | CAS: 41838-46-4

4-Amino-1-methylpiperidine (cas: 41838-46-4) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Safety of 4-Amino-1-methylpiperidine

Reversible thermochromism, temperature-dependent conductivity and high stability for a laminated bismuth(III)-silver(I) hybrid double perovskite was written by Lassoued, Mohamed Saber;Wang, Tengbo;Faizan, Ahmad;Li, Qian-Wen;Chen, Wei-Peng;Zheng, Yan-Zhen. And the article was included in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2022.Safety of 4-Amino-1-methylpiperidine This article mentions the following:

Lead-free hybrid perovskite materials have attracted tremendous consideration due to their applications in photovoltaics, optoelectronics, thermal sensors, etc. Herein, we isolated a new stable semiconductive 2D bismuth(III)-silver(I) iodide hybrid double perovskite formulated as (H2MPP)2[BiAgI8], where H2MPP = 1-methylpiperidinium-4-amine, with reversible solid-state thermochromism, a narrow bandgap and considerable temperature-dependent conductivity Upon heating from 150 K to 450 K, (H2MPP)2[BiAgI8] crystals exhibit a reversible color change between orange and dark red. The associated structural changes were monitored using in situ single-crystal X-ray diffraction (SCXRD), powder X-ray diffraction (PXRD), UV-visible absorption and Raman spectroscopy. Besides, the elec. conductivity of (H2MPP)2[BiAgI8] changes over four orders of magnitude upon thermochromism (up to 1.51 x 10-6 S cm-1 at 450 K) and showed an efficiently enhanced photocurrent switching on/off ratio. Moreover, the (H2MPP)2[BiAgI8] crystals can be processed into thin films via spin coating and exhibit high stability under heat and moisture, which is indicative of their potential optoelectronic applications based on thermochromism. In the experiment, the researchers used many compounds, for example, 4-Amino-1-methylpiperidine (cas: 41838-46-4Safety of 4-Amino-1-methylpiperidine).

4-Amino-1-methylpiperidine (cas: 41838-46-4) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Safety of 4-Amino-1-methylpiperidine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Zheng, Haoting et al. published their research in Bioorganic & Medicinal Chemistry in 2022 | CAS: 41838-46-4

4-Amino-1-methylpiperidine (cas: 41838-46-4) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Synthetic Route of C6H14N2

Quinazoline-based hydroxamic acid derivatives as dual histone methylation and deacetylation inhibitors for potential anticancer agents was written by Zheng, Haoting;Dai, Qiuzi;Yuan, Zigao;Fan, Tingting;Zhang, Cunlong;Liu, Zijian;Chu, Bizhu;Sun, Qinsheng;Chen, Yan;Jiang, Yuyang. And the article was included in Bioorganic & Medicinal Chemistry in 2022.Synthetic Route of C6H14N2 This article mentions the following:

In the present work, a series of quinazoline-based hydroxamic acid derivatives I (n = 5, 6; R = Me, i-Pr, Bn), II and III as dual GLP and HDAC inhibitors were designed and synthesized. These hybrid compounds I, II and III showed potent enzymic inhibitory activities against GLP and HDAC1/6 with IC50 values in the nanomolar range of less than 190 nM. Furthermore, most of the compounds displayed significant broad spectrum cytotoxic activities apart from I (n = 5; R = i-Pr) and III against all the tested cancer cells with IC50 values less than 50μM. Compounds I (n = 5; R = Me, n = 5; R = Bn) and II (R = Bn) (IV) showed more potent cytotoxic activities than I (n = 6; R = Me, n = 6; R = i-Pr) and II (R = i-Pr) in those cancer cells. Especially, compound IV showed potent inhibitory potency activity against both GLP and HDAC1/6 with IC50 values of 1.3, 89, 13 nM. Besides, IV exhibited the most potent antiproliferative activity against all the tested cancer cells. Further evaluations indicated that IV could inhibit the methylation and deacetylation of H3K9 on protein level. Moreover, IV could induce cancer cell apoptosis, G0/G1 cell cycle arrest, and partly block migration and invasion. All these thorough evaluations warranted IV as a promising lead compound worth further optimization and development for cancer therapy. In the experiment, the researchers used many compounds, for example, 4-Amino-1-methylpiperidine (cas: 41838-46-4Synthetic Route of C6H14N2).

4-Amino-1-methylpiperidine (cas: 41838-46-4) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Synthetic Route of C6H14N2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Lassoued, Mohamed Saber et al. published their research in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2022 | CAS: 41838-46-4

4-Amino-1-methylpiperidine (cas: 41838-46-4) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Safety of 4-Amino-1-methylpiperidine

Reversible thermochromism, temperature-dependent conductivity and high stability for a laminated bismuth(III)-silver(I) hybrid double perovskite was written by Lassoued, Mohamed Saber;Wang, Tengbo;Faizan, Ahmad;Li, Qian-Wen;Chen, Wei-Peng;Zheng, Yan-Zhen. And the article was included in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2022.Safety of 4-Amino-1-methylpiperidine This article mentions the following:

Lead-free hybrid perovskite materials have attracted tremendous consideration due to their applications in photovoltaics, optoelectronics, thermal sensors, etc. Herein, we isolated a new stable semiconductive 2D bismuth(III)-silver(I) iodide hybrid double perovskite formulated as (H2MPP)2[BiAgI8], where H2MPP = 1-methylpiperidinium-4-amine, with reversible solid-state thermochromism, a narrow bandgap and considerable temperature-dependent conductivity Upon heating from 150 K to 450 K, (H2MPP)2[BiAgI8] crystals exhibit a reversible color change between orange and dark red. The associated structural changes were monitored using in situ single-crystal X-ray diffraction (SCXRD), powder X-ray diffraction (PXRD), UV-visible absorption and Raman spectroscopy. Besides, the elec. conductivity of (H2MPP)2[BiAgI8] changes over four orders of magnitude upon thermochromism (up to 1.51 x 10-6 S cm-1 at 450 K) and showed an efficiently enhanced photocurrent switching on/off ratio. Moreover, the (H2MPP)2[BiAgI8] crystals can be processed into thin films via spin coating and exhibit high stability under heat and moisture, which is indicative of their potential optoelectronic applications based on thermochromism. In the experiment, the researchers used many compounds, for example, 4-Amino-1-methylpiperidine (cas: 41838-46-4Safety of 4-Amino-1-methylpiperidine).

4-Amino-1-methylpiperidine (cas: 41838-46-4) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Safety of 4-Amino-1-methylpiperidine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Zheng, Haoting et al. published their research in Bioorganic & Medicinal Chemistry in 2022 | CAS: 41838-46-4

4-Amino-1-methylpiperidine (cas: 41838-46-4) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Synthetic Route of C6H14N2

Quinazoline-based hydroxamic acid derivatives as dual histone methylation and deacetylation inhibitors for potential anticancer agents was written by Zheng, Haoting;Dai, Qiuzi;Yuan, Zigao;Fan, Tingting;Zhang, Cunlong;Liu, Zijian;Chu, Bizhu;Sun, Qinsheng;Chen, Yan;Jiang, Yuyang. And the article was included in Bioorganic & Medicinal Chemistry in 2022.Synthetic Route of C6H14N2 This article mentions the following:

In the present work, a series of quinazoline-based hydroxamic acid derivatives I (n = 5, 6; R = Me, i-Pr, Bn), II and III as dual GLP and HDAC inhibitors were designed and synthesized. These hybrid compounds I, II and III showed potent enzymic inhibitory activities against GLP and HDAC1/6 with IC50 values in the nanomolar range of less than 190 nM. Furthermore, most of the compounds displayed significant broad spectrum cytotoxic activities apart from I (n = 5; R = i-Pr) and III against all the tested cancer cells with IC50 values less than 50μM. Compounds I (n = 5; R = Me, n = 5; R = Bn) and II (R = Bn) (IV) showed more potent cytotoxic activities than I (n = 6; R = Me, n = 6; R = i-Pr) and II (R = i-Pr) in those cancer cells. Especially, compound IV showed potent inhibitory potency activity against both GLP and HDAC1/6 with IC50 values of 1.3, 89, 13 nM. Besides, IV exhibited the most potent antiproliferative activity against all the tested cancer cells. Further evaluations indicated that IV could inhibit the methylation and deacetylation of H3K9 on protein level. Moreover, IV could induce cancer cell apoptosis, G0/G1 cell cycle arrest, and partly block migration and invasion. All these thorough evaluations warranted IV as a promising lead compound worth further optimization and development for cancer therapy. In the experiment, the researchers used many compounds, for example, 4-Amino-1-methylpiperidine (cas: 41838-46-4Synthetic Route of C6H14N2).

4-Amino-1-methylpiperidine (cas: 41838-46-4) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Synthetic Route of C6H14N2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Lassoued, Mohamed Saber et al. published their research in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2022 | CAS: 41838-46-4

4-Amino-1-methylpiperidine (cas: 41838-46-4) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Safety of 4-Amino-1-methylpiperidine

Reversible thermochromism, temperature-dependent conductivity and high stability for a laminated bismuth(III)-silver(I) hybrid double perovskite was written by Lassoued, Mohamed Saber;Wang, Tengbo;Faizan, Ahmad;Li, Qian-Wen;Chen, Wei-Peng;Zheng, Yan-Zhen. And the article was included in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2022.Safety of 4-Amino-1-methylpiperidine This article mentions the following:

Lead-free hybrid perovskite materials have attracted tremendous consideration due to their applications in photovoltaics, optoelectronics, thermal sensors, etc. Herein, we isolated a new stable semiconductive 2D bismuth(III)-silver(I) iodide hybrid double perovskite formulated as (H2MPP)2[BiAgI8], where H2MPP = 1-methylpiperidinium-4-amine, with reversible solid-state thermochromism, a narrow bandgap and considerable temperature-dependent conductivity Upon heating from 150 K to 450 K, (H2MPP)2[BiAgI8] crystals exhibit a reversible color change between orange and dark red. The associated structural changes were monitored using in situ single-crystal X-ray diffraction (SCXRD), powder X-ray diffraction (PXRD), UV-visible absorption and Raman spectroscopy. Besides, the elec. conductivity of (H2MPP)2[BiAgI8] changes over four orders of magnitude upon thermochromism (up to 1.51 x 10-6 S cm-1 at 450 K) and showed an efficiently enhanced photocurrent switching on/off ratio. Moreover, the (H2MPP)2[BiAgI8] crystals can be processed into thin films via spin coating and exhibit high stability under heat and moisture, which is indicative of their potential optoelectronic applications based on thermochromism. In the experiment, the researchers used many compounds, for example, 4-Amino-1-methylpiperidine (cas: 41838-46-4Safety of 4-Amino-1-methylpiperidine).

4-Amino-1-methylpiperidine (cas: 41838-46-4) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Safety of 4-Amino-1-methylpiperidine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem