Tag: 1029413-55-5

1029413-55-5, tert-Butyl 4-(4-amino-1H-pyrazol-1-yl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 4.178-[ [5-Fluoro-2- [ ri-(4-piperidyl)pyrazol-4-yll amino I -4-pyridyll amino I -2-methyl-3.,4- dihydroisoq uinolin- 1-one A mixture of 8-[(2-chloro-5-fluoropyridin-4-yl)amino]-2-methyl-3,4- dihydroisoquinolin- 1-one (100 mg, 0.33 mmol), tert-butyi 4-(4-aminopyrazol-l- yl)piperidine-l-carboxylate (114 mg, 0.43 mmol), sodium te/t-butoxide (51.5 mg, 0.54 mmol) and 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene (41.4 mg, 0.07 mmol) in anhydrous dioxane (3 mL) was degassed with nitrogen and then bis(dibenzylideneacetone)palladium (32.7 mg, 0.057 mmol) was added. The mixture was heated at 15O0C for 30 minutes in a microwave reactor. MeOH (0.40 mL) was added and the mixture loaded onto an SCX column. The product was eluted first with MeOH and then with a 7M solution of NH3 in MeOH. Fractions containing product were combined and evaporated. The residue was stirred in a solution of HCl in dioxane (2 mL) overnight and then purified directly by preparative HPLC. Fractions containing product were combined and evaporated to afford example 4.17 (1.8 mg, 1% yield); 1H NMR spectrum (300 MHz, DMSO): delta 1.70 – 1.79 (2H, m), 1.89 (2H, d), 2.26 – 2.28 (2H, m), 2.54 (IH, d), 2.60 – 2.64 (IH, m), 2.71 – 2.74 (2H, m), 2.96 (IH, d), 3.00 (IH, s), 3.05 (3H, s), 3.55 (2H, t), 4.06 – 4.14; Mass spectrum: m/z (ESI+) (M+H)+ = 436.63.

1029413-55-5 tert-Butyl 4-(4-amino-1H-pyrazol-1-yl)piperidine-1-carboxylate 27281520, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/153589; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem