Tag: 100-200

Preparation of Δ¹-pyrroline-2-carboxylic acid and a new proline synthesis was written by Hasse, Kurt;Wieland, Alfred. And the article was included in Chemische Berichte in 1960.HPLC of Formula: 30727-21-0 The following contents are mentioned in the article:

2,3-Dioxopiperidine-4-carboxylic acid Et ester (I), obtained by condensation of 2-pyrrolidone (II) with (CO₂Et)₂ (III), was converted by hydrolysis to H₂N(CH₂)₃COCO₂H.HCl (IV) and this hydrogenated to yield DL-proline (V). K (10 g.) dissolved in 100 cc. absolute EtOH, the solution evaporated in vacuo, the residue dissolved in 200 cc. Et₂O, the solution treated with 25 cc. II and 50 cc. III in 50 cc. Et₂O, the mixture treated after 24 hrs. with 100 cc. 1:4 HCl, and the Et₂O phase concentrated gave 90% [EtO₂C(CH₂)₃NHCO]₂ (VI), m. 106° (H₂O or EtOH). VI (1 g.) in 5 cc. 6N HCl heated 1 hr. at 80° and concentrated gave [HO₂C(CH₂)₃NHCO]₂, m. 210°. II condensed in the usual manner with III, the mixture acidified with HCl, and the Et₂O phase evaporated in vacuo at 120° gave 3-ethoxalyl-2-pyrrolidone (VII), m. 132° (EtOH). 3-Oxalyl-2-pyrrolidone (VIII) (0.75 g.) and 20 cc. alc. HCl kept 36 hrs. at room temperature and evaporated in vacuo yielded VII, m. 131-2° (C₆H₆). VII (0.5 g.) in 5 cc. 6N HCl heated 0.5 hr. at 80° gave VIII, decomposing above 205°. K (4 g.) under 60 cc. Et₂O treated during 1 hr. with 13.8 g. absolute EtOH, warmed 3-4 hrs. on the water bath, treated at 0-5° with stirring with 14.6 g. III, the mixture treated after 10 min. during 0.5 hr. with 18.9 g. N-benzoyl-2-pyrrolidone in 27 cc. dry dioxane, diluted after 1 hr. with 150 cc. Et₂O, and filtered after 12 hrs., the residue dried in vacuo (23 g.), added with stirring to 40 cc. H₂O, 15 cc. HCl, and 30 cc. CHCl₃, the CHCl₃ phase evaporated, the residual oil dissolved at 90° with stirring during 10 min. in 40 cc. 6N HCl, and the hot solution filtered and cooled gave 2 g. VIII, needles, decomposing above 205° with sintering; the mother liquor gave 5.6 g. HO₂CCONH(CH₂)₃CO₂H, m. 163-4° (decomposition) (H₂O or Me₂CO). VIII (20.4 mg.) in 10 cc. H₂O treated with 15 cc. 1% 2,4-(O₂N)₂C₆H₃NHNH₂ in 2N HCl gave the 2,4-dinitrophenylhydrazone of VIII, m. 221° (decomposition). K (20 g.), a few crystals of iodine and a small amount of Hg₂Cl₂ in 50 cc. absolute C₆H₆ treated with 40 cc. absolute EtOH in portions, the mixture diluted with 30 cc. EtOH in 150 cc. C₆H₆, warmed slightly, diluted further with 300 cc. C₆H₆, treated with 43 g. II and 73 g. III, refluxed 18 hrs. with stirring, and treated with 80 cc. 6N HCl, the hot C₆H₆ layer decanted, the aqueous phase extracted with C₆H₆, and the combined C₆H₆ solutions worked up yielded 80% I, m. 148°. I (370 mg.) in EtOH hydrogenated at 20°/760 mm. over PtO₂, filtered, and evaporated gave 3-hydroxy-4-carbethoxy-2-piperidone, m. 121-2° (C₆H₆). I (5.3 g.) and 80 cc. 6N HCl refluxed 6 min. (in larger runs 20 min.) and evaporated at 35°/12 mm., and the residue refrigerated several hrs., filtered, washed with cold HCl, and dried yielded IV, m. 113° (HCl-AcOH-Et₂O). VIII (1.03 g.) and 35 cc. 6N HCl refluxed 1 hr. and evaporated at 35°/16 mm., the residue dissolved in H₂O and chromatographed on Dowex 50-X-8 (H form), and the fractions from 207-358 cc. evaporated gave 0.7 g. IV, m. 113° (decomposition). IV (48.7 mg.) hydrogenated 3 hrs. at 21°/755 mm. over PtO₂, filtered, treated with Ag₂O and then H₂S, refiltered, and evaporated, and the residue and 48 mg. picric acid dissolved in hot glacial AcOH and diluted with Et₂O gave the picrate of V, m. 134-5°. I (12.5 g.) and 200 cc. 6N HCl refluxed 7 min., concentrated at 40°/25 mm. to 30 cc., diluted with 120 cc. H₂O, hydrogenated 5 hrs. at 25°/1 atm. over 270 mg. PtO₂, filtered, placed on Amberlite IR-4B, washed with 1.3 l. H₂O, and eluted gave 5.51 g. pure V. This study involved multiple reactions and reactants, such as Ethyl 2,3-dioxopiperidine-4-carboxylate (cas: 30727-21-0HPLC of Formula: 30727-21-0).

Ethyl 2,3-dioxopiperidine-4-carboxylate (cas: 30727-21-0) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.HPLC of Formula: 30727-21-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Acyl-lactone rearrangement. XXIII. Syntheses of cyclic amino acids by the reaction principle of the acyl-lactone rearrangement was written by Buechel, Karl Heinz;Korte, Friedhelm. And the article was included in Chemische Berichte in 1962.Name: Ethyl 2,3-dioxopiperidine-4-carboxylate The following contents are mentioned in the article:

3-Ethoxalyl-2-pyrrolidones and 3-ethoxalyl-2-piperidones were converted by heating with decarboxylation and rearrangement and by subsequent catalytic hydrogenation to DL-hygrinic acid (I), DL-proline (II), and DL-N-methylpipecolinic acid (III), resp., in high yields. N-Methyl-2-pyrrolidone and (CO₂Et)₂ (IV) were condensed with coarsely cut and with powd. K to yield 56 and 60-65%, resp., 3-ethoxalyl-N-methyl-2-pyrrolidone (V). V (1 g.) in 25 cc. concentrated HCl refluxed 20 hrs., concentrated in vacuo, diluted with 20 cc. H₂O, treated with 1 g. 2,4-(O₂N)₂C₆H₃NHNH₂ in 170 cc. 2N HCl, and kept several days gave the 2,4-dinitrophenylhydrazone of MeNH(CH₂)₃-COCO₂H, m. 183-4° (2N HCl). V (10 g.) in 60 cc. concentrated HCl refluxed 20 hrs. until the maximum at 285 mμ had disappeared, concentrated to 50 cc., cooled, filtered, from 0.1-0.3 g. V, diluted with H₂O, hydrogenated over 0.5 g. PtO₂, filtered, and evaporated, and the residual I.HCl (9 g.) dissolved in H₂O, passed through weakly basic Duolite A 7, and evaporated gave I, m. 174-5° (EtOH-Et₂O); I.HCl m. 183-5° (EtOH-Et₂O). 2-Pyrrolidone heated with excess Ac₂O gave 95% N-Ac derivative (VI), b₁₂ 109-10°. VI (127 g.) and 204 g. IV in 100 cc. dry Et₂O added dropwise at -5 to 0° to 39.1 g. powd. K and 1 cc. absolute EtOH in 400 cc. dry Et₂O, stirred 8 hrs., added with stirring and cooling to 500 cc. 2N HCl, and extracted with CHCl₃ gave 209 g. (crude) 3-ethoxalyl-N-acetyl-2-pyrrolidone (VII), b_0.05 90-5°, blue-violet with FeCl₃; the higher boiling fractions deposited 3-ethoxalyl-2-pyrrolidone, m. 134-6° (ligroine), blue with FeCl₃. Crude VII (5 g.) and 20 cc. 6N HCl heated 24 hrs. at 60° gave 1.2 g. 3-oxalyl-2-pyrrolidone, m. 208-10° (decomposition). VI (127 g.) and 180 g. IV added dropwise with stirring to 39.1 g. K and 1 cc. absolute EtOH in 400 cc. dry MePh at about 100° and worked up in the usual manner yielded 160 g. (crude) [EtO₂C(CH₂)₃NHCO]₂ (VIII), needles, m. 103-6° (ligroine, b. 80-110°). VIII refluxed with 6N HCl gave [HO₂C-(CH₂)₃NHCO]₂, m. 212°. The brown semisolid residue from the mother liquor from VIII treated in EtOH with C, concentrated, and diluted with petr. ether gave 26 g. 2,3-dioxo-4-carbethoxypiperidine, m. 148° (C₆H₆), ruby-red with FeCl₃. VII (22.7 g.) in concentrated HCl refluxed 1 hr., concentrated to half-volume, diluted with an equal volume H₂O, hydrogenated over 0.5 g. PtO₂, and worked up, and the residual crude II.HCl dissolved in H₂O, passed through Duolite A 7, eluted with 1.5 l. H₂O, and evaporated yielded 9 g. II, m. 214-15°. VII treated in the usual manner with 2,4-(O₂N)₂C₆H₃NH-NH₂ yielded the 2,4-dinitrophenylhydrazone of H₂N(CH₂)₃-COCO₂H, yellow, m. 217-18° (2N HCl). α-Ethoxalyl-N-methyl-2-piperidone (21.3 g.) added to 100 cc. boiling 6N HCl, refluxed about 5 min., concentrated to about 40 cc., diluted with an equal volume H₂O, hydrogenated over 0.5 g. PtO₂, and worked up yielded 17.9 g. III.HCl, m. 195-200°. III.HCl in H₂O treated with Amberlite 4-B and evaporated gave 14.0 g. III, m. 208-10° (EtOH-Et₂O). III treated in the usual manner with 2,4-(O₂N)₂C₆H₃-NHNH₂ gave the 2,4-dinitrophenylhydrazone of MeNH(CH₂)₄-COCO₂H, yellow needles, m. 207° (2N HCl). III (2.9 g.) in MeOH methylated with MeI-Ag₂O yielded DL-homostachydrine (IX), very hygroscopic crystals, m. 207-8° (EtOH-Et₂O); IX.-HCl, m. 211° (EtOH-Et₂O). This study involved multiple reactions and reactants, such as Ethyl 2,3-dioxopiperidine-4-carboxylate (cas: 30727-21-0Name: Ethyl 2,3-dioxopiperidine-4-carboxylate).

Ethyl 2,3-dioxopiperidine-4-carboxylate (cas: 30727-21-0) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Name: Ethyl 2,3-dioxopiperidine-4-carboxylate

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Reference of TriacetonamineOn September 1, 2021 ,《Catalytic ozonation for metoprolol and ibuprofen removal over different MnO2 nanocrystals: Efficiency, transformation and mechanism》 was published in Science of the Total Environment. The article was written by He, Yuan; Wang, Liangjie; Chen, Zhan; Shen, Bo; Wei, Jinshan; Zeng, Ping; Wen, Xianghua. The article contains the following contents:

Manganese dioxide has been widely recognized as catalyst in catalytic ozonation for organic pollutants removal from wastewater in recent decades. However, few studies focus on the structure-activity relationship of MnO2 and catalytic ozonation mechanism in water. In the present study, the oxidative reactivity of three different crystal phases of MnO2 corresponding to α-MnO2, β-MnO2 and γ-MnO2 towards metoprolol (MET) and ibuprofen (IBU) were evaluated. α-MnO2 was found to contain the most abundant oxygen vacancy and readily reducible surface adsorbed oxygen (O2-, O-, OH-), which facilitated an increase of ozone utilization and the highest catalytic performance with 99% degradation efficiency for IBU and MET. α-MnO2 was then selected to investigate the optimum key operating parameters with a result of catalyst dosage 0.1 g/L, ozone dosage 1 mg/min and an initial pH 7. The introduction of α-MnO2 promoted reactive oxygen species (O2-, O-, OH-) generation which played significant roles in IBU degradation Probable degradation pathways of MET and IBU were proposed according to the organic intermediates identified and the reaction sites based on d. function theory (DFT) calculations The present study deepened our understanding on the MnO2 catalyzed ozonation and provided reference to enhance the process efficiency. The experimental part of the paper was very detailed, including the reaction process of Triacetonamine(cas: 826-36-8Reference of Triacetonamine)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Reference of Triacetonamine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

HPLC of Formula: 39546-32-2On September 9, 2019 ,《One-Pot Parallel Synthesis of 5-(Dialkylamino)tetrazoles》 was published in ACS Combinatorial Science. The article was written by Savych, Olena; Kuchkovska, Yuliya O.; Bogolyubsky, Andrey V.; Konovets, Anzhelika I.; Gubina, Kateryna E.; Pipko, Sergey E.; Zhemera, Anton V.; Grishchenko, Alexander V.; Khomenko, Dmytro N.; Brovarets, Volodymyr S.; Doroschuk, Roman; Moroz, Yurii S.; Grygorenko, Oleksandr O.. The article contains the following contents:

Two protocols for the combinatorial synthesis of 5-(dialkylamino)tetrazoles were developed. The best success rate (67%) was shown by the method that used primary and secondary amines, 2,2,2-trifluoroethylthiocarbamate, and sodium azide as the starting reagents. The key steps included the formation of unsym. thiourea, subsequent alkylation with 1,3-propane sultone and cyclization with azide anion. A 559-member aminotetrazole library was synthesized by this approach; the overall readily accessible (REAL) chem. space covered by the method exceeded 7 million feasible compounds The results came from multiple reactions, including the reaction of Piperidine-4-carboxamide(cas: 39546-32-2HPLC of Formula: 39546-32-2)

Piperidine-4-carboxamide(cas: 39546-32-2) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.HPLC of Formula: 39546-32-2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Recommanded Product: 2-(Piperidin-4-yl)ethanolIn 2012 ,《Discovery of (2S)-1-[4-(2-{6-Amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a Purine-Based Hsp90 Inhibitor》 appeared in Journal of Medicinal Chemistry. The author of the article were Kim, Se-Ho; Bajji, Ashok; Tangallapally, Rajendra; Markovitz, Benjamin; Trovato, Richard; Shenderovich, Mark; Baichwal, Vijay; Bartel, Paul; Cimbora, Daniel; McKinnon, Rena; Robinson, Rosann; Papac, Damon; Wettstein, Daniel; Carlson, Robert; Yager, Kraig M.. The article conveys some information:

Modulation of Hsp90 (heat shock protein 90) function has been recognized as an attractive approach for cancer treatment, since many cancer cells depend on Hsp90 to maintain cellular homeostasis. This has spurred the search for small-mol. Hsp90 inhibitors. Here we describe our lead optimization studies centered on the purine-based Hsp90 inhibitor 28a (I; R = CHO) containing a piperidine moiety at the purine N9 position. In this study, key SAR was established for the piperidine N-substituent and for the congeners of the 1,3-benzodioxole at C8. These efforts led to the identification of orally bioavailable 28g [I; R = (S)-2-hydroxypropanoyl] that exhibits good in vitro profiles and a characteristic mol. biomarker signature of Hsp90 inhibition both in vitro and in vivo. Favorable pharmacokinetic properties along with significant antitumor effects in multiple human cancer xenograft models led to the selection of 28g (MPC-3100) as a clin. candidate. The experimental part of the paper was very detailed, including the reaction process of 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Recommanded Product: 2-(Piperidin-4-yl)ethanol)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAKRecommanded Product: 2-(Piperidin-4-yl)ethanol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

SDS of cas: 622-26-4In 2019 ,《Fluorophenols bearing nitrogenated heterocycle moieties, a class of novel Keap1-Nrf2 protein-protein interaction inhibitors: synthesis, antioxidant stress screening and molecular docking》 appeared in Medicinal Chemistry Research. The author of the article were Feng, Xiu E.; Kong, De Peng; Ban, Shu Rong; Ge, Rui; Li, Qing Shan. The article conveys some information:

In the present study, we introduced the nitrogenated heterocycles and fluorine atoms into the 2,5′-dibromo-4,5,2′-trihydroxyl diphenylmethanone (LM49), a bromophenol analog previously reported for its strong antioxidant ability involving in the Keap1-Nrf2 pathway. Twenty-seven fluorophenols 6a-6g, 8a-8k, 10a-10g, and 12a-12b were prepared, evaluated for their antioxidant activity in EA.hy926 cells, and investigated their interacted approach and probable mode of action with key protein Keap1 by mol. docking. Fluorophenols 6f, 8d, 8f, 8h, and 8i with EC50 values ranging from 0.82 to 6.71 μM were found to be more active compared with the standard control quercetin (EC50 = 18 μM). Among them, compound 8h with an EC50 value of 0.82 μM showed the identical activity to lead compound LM49 (EC50 = 0.7 μM). Moreover, the preferable water solubility and forming salt possibility of 8h contribute to its druggability. Further mol. docking of the optimal compound 8h with key protein Keap1 indicated that 8h stably bonded to the receptor protein by the formation of hydrogen bonds, the conjugated six-membered ring was close to the key residue Arg-415 attached to the Nrf2 on Keap1-Kelch, affecting its properties, and the change leaded to the dissociation of Nrf2 from the junction with Keap1-Kelch into the nucleus exerting its antioxidant protective effect. This study introduced a class of fluorophenols containing nitrogenated heterocycles for the development of novel Keap1-Nrf2 protein-protein interaction (PPI) inhibitors. Keap1-Kelch is suggested the most potential target protein for such class of halophenols. After reading the article, we found that the author used 2-(Piperidin-4-yl)ethanol(cas: 622-26-4SDS of cas: 622-26-4)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAKSDS of cas: 622-26-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Name: 1-Methyl-4-piperidoneIn 2020 ,《Chemically stable poly(meta-terphenyl piperidinium) with highly conductive side chain for alkaline fuel cell membranes》 appeared in Journal of Membrane Science. The author of the article were Lu, Chuanrui; Long, Chuan; Li, Yunxi; Li, Ziming; Zhu, Hong. The article conveys some information:

Poly(arylene piperidine)s (PAPs) backbones, which do not contain unstable ether bonds, was synthesized by one-pot, metal-free superacid-catalyzed polymerization for anion exchange membranes (AEMs) preparation Meta-terphenyl as a monomer of polymer to regulate the morphol. and properties of AEM was also used due to its spatially torsional configuration instead of the recently reported linear structure of meta-terphenyl. Long flexible hydrophilic chains were grafted onto poly(meta terphenyl piperidinium) (m-PTP) backbone to form four cationic functionalized side chains, promoting efficient transfer of OH- and optimizing the hydrophilic/hydrophobic microphase separation structure. The resulting AEM shows a high ion conductivity of 164 mS/cm (m-PTP-TFPE-21) at 80°C. Furthermore, stable piperidine cation and long alkyl spacer chain contributed to the excellent alkali stability of m-PTP-TFPE-TQA membrane which shows only 11.67% and 12.73% degradation in ion conductivity and IEC, resp., after soaking in 2 M NaOH at 80°C for 1500 h. The peak power d. of the H2/O2 single cell using m-PTP-TFPE-14 is 269 mW/cm2 at a c.d. of 540 mA/cm2 at 80°C. The results came from multiple reactions, including the reaction of 1-Methyl-4-piperidone(cas: 1445-73-4Name: 1-Methyl-4-piperidone)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Name: 1-Methyl-4-piperidone

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2022,Yang, Lincan; Wang, Zhiqian; Wang, Fanghui; Wang, Zhongming; Zhu, Hong published an article in Journal of Membrane Science. The title of the article was 《Poly(aryl piperidinium) anion exchange membranes with cationic extender sidechain for fuel cells》.Electric Literature of C6H11NO The author mentioned the following in the article:

Anion-exchange membrane fuel cells (AEMFCs) is a promising solution to decrease the cost of fuel cell, because it is adaptable to non-noble-metals catalysts and low-cost stack components. However, anion exchange membranes (AEMs), a crucial component of AEMFCs devices, with desired properties (high ions conductivity, excellent chem. stability, robust mech. strength, etc.) are currently unavailable. In this paper, poly(biphenyl N-methylpiperidine) (PBP) was synthesized as the backbones of AEMs, which could provide good chem. stability and robust mech. strength. Quaternary ammonium cations containing various types of substituent sidechains, including hydrophobic alkyl chain, hydrophilic PEG chain and multi-PEG chains, were introduced onto the PBP backbones, and resulting AEMs were named PBP-alkyl, PBP-PEG and PBP-TPEG, resp. The relationship between AEMs structure and performance were studied, and mol. dynamics (MD) simulations were carried out to microcosmically reveal the mechanism of structure-activity relationship. All the PBP-based AEMs have acceptable alk. stability and performance loss is less than 10% under 2 M NaOH at 80 °C for about 500 h. PBP-PEG has the highest ions conductivity of 97.3 mS cm-1 and lowest water uptake (WU), while PBP-TPEG has the lowest ions conductivity of 56.1 mS cm-1 and highest WU. For single cell evaluations at 80 °C under H2/O2 condition, AEMFC containing PBP-PEG membrane bursts out a highest peak power d. of 373 mW cm2, while PBP-alkyl and PBP-TPEG only achieve 133 and 93 mW cm-2, resp. MD results show the water channel of PBP-PEG is denser and more continuous than other structures, and the proportion of completely hydrated transport is higher than other structures, which contributes to the increase of overall performance. On the other hand, DFT results show the low basicity and strong hydrophily of cation containing multi-PEG substituents leads to the poor performance of PBP-TPEG. Therefore, for the design of AEMs mol. structures with outstanding performances, hydrophilic PEG spacer chain is more effective than hydrophobic alkyl spacer chain, and PEG is more effective as a spacer chain than as an extender chain. The experimental part of the paper was very detailed, including the reaction process of 1-Methyl-4-piperidone(cas: 1445-73-4Electric Literature of C6H11NO)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Electric Literature of C6H11NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2022,Kim, Hae Min; Hu, Chuan; Wang, Ho Hyun; Park, Jong Hyeong; Chen, Nanjun; Lee, Young Moo published an article in Journal of Membrane Science. The title of the article was 《Impact of side-chains in poly(dibenzyl-co-terphenyl piperidinium) copolymers for anion exchange membrane fuel cells》.Application of 1445-73-4 The author mentioned the following in the article:

Anion exchange membrane fuel cells (AEMFCs) have experienced rapid advancement in the past few years due to the discovery of high-performance AEMs and ionomers. Here, we report a series of side-chain-type poly(dibenzbeyl-co-terphenyl piperidinium) (s-PDTP) copolymers as ionomers and membranes for AEMFC applications. The features of aryl ether-free PDTP polymer backbone and pendent ammonium groups endow both high alk. stability and excellent micromorphol. to s-PDTP copolymers. These ion-exchange-capacity (IEC)-controlled s-PDTP membranes possess high OH- conductivity >120 mS cm-1 at 80 °C, reasonable mol. weight (Mw = 150-290 kDa), and excellent ex-situ durability in 1 M NaOH at 80 °C for 1000 h (∼90% conductivity remaining). For ionomer research, s-PDTP ionomers with moderate IEC (∼3.0 mmol g-1) and rational water uptake (∼200%) exhibit optimal AEMFC performance based on a PDTP membrane compared to high-IEC or low-IEC s-PDTP ionomers (>3.4 mmol g-1 or <2.4 mmol g-1). Based on Pt/C, s-PDTP-based AEMFCs reach a peak power d. (PPD) of 1.47 W cm-2 in H2-O2 and 1.04 W cm-2 in H2-air (CO2-free) at 80 °C. The results came from multiple reactions, including the reaction of 1-Methyl-4-piperidone(cas: 1445-73-4Application of 1445-73-4)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Application of 1445-73-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2022,Gou, Wei Wei; Gao, Wei Ting; Gao, Xue Lang; Zhang, Qiu Gen; Zhu, Ai Mei; Liu, Qing Lin published an article in Journal of Membrane Science. The title of the article was 《Highly conductive fluorinated poly(biphenyl piperidinium) anion exchange membranes with robust durability》.COA of Formula: C6H11NO The author mentioned the following in the article:

To prepare anion exchange membranes (AEMs) that possess an excellent alk. resistance, a competitive conductivity and a low swelling ratio (SR), a reasonable mol. structure design is particularly important. Herein, we synthesized ether-free fluoropolymers via a superacid catalyzed polyhydroxyalkylation reaction in one pot, and grafted long flexible multipiperidine cation side chains to different positions of the backbone through Menshutkin reaction. We investigated the effect of hydrophilic-hydrophobic polarity difference on the microphase separation When the ionic liquid is grafted closer to the fluorine-contained group, AEMs exhibit a more obvious microphase separated structure and larger ion clusters as confirmed by morphol. observation. Mol. dynamics simulations also confirmed that the construction of ion channels in PBPip-QAPBF-30% is more efficient than in QAPBPip-PBF-30%. The resulting PBPip-QAPBF-30% AEM exhibits the highest OH- conductivity of 156.4 mS cm-1 with a low SR of 12.9% at 80°C. The QAPBPip-PBF-30% and PBPip-QAPBF-30% AEMs both show an excellent alk. stability with the OH- conductivity retention of 93.2% and 95.0% correspondingly after being treated in a 2 M NaOH solution at 80°C for 1080 h. Moreover, the peak power d. of a single cell equipped with PBPip-QAPBF-30% reaches 324.5 mW cm-2 at a c.d. of 550 mA cm-2. In addition to this study using 1-Methyl-4-piperidone, there are many other studies that have used 1-Methyl-4-piperidone(cas: 1445-73-4COA of Formula: C6H11NO) was used in this study.

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.COA of Formula: C6H11NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem