Tag: 100-200

From bipyridines to tobacco alkaloids and related compounds was written by Plaquevent, Jean-Christophe;Chichaoui, Ilhame. And the article was included in Bulletin de la Societe Chimique de France in 1996.Formula: C10H14N2 The following contents are mentioned in the article:

Structural considerations led to the hypothesis that a chem. relationship could exist between pyridine and pyrrolidine alkaloids and experiments were carried out in order to establish a correlation between the two classes. Nicotine holds a central position in these studies and the main part of this work was devoted to the synthesis of nicotine starting from bipyridines. It was thus necessary to determine the conditions for selective reactions on one aromatic ring of bipyridines (N-methylation, N-oxidation and reduction of the heterocycle). A ring contraction procedure gave nicotine from 3,3′-bipyridine. Complementary studies yielded various isomers of piperidinylpyridines in a regiochem. controlled manner. This study involved multiple reactions and reactants, such as 3-(Piperidin-3-yl)pyridine (cas: 31251-28-2Formula: C10H14N2).

3-(Piperidin-3-yl)pyridine (cas: 31251-28-2) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Formula: C10H14N2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Dependence of the inhibiting effect of bipyridines and their hydro-derivatives on configuration was written by Forostyan, Yu. N.. And the article was included in Zashchita Metallov in 1983.Category: piperidines The following contents are mentioned in the article:

The inhibiting effect of bipyridines and their hydroderivs. (concentration 0.1%) on corrosion of steel St3  [39296-41-8] in solutions of 15% H₂SO₄ at 22° and constant mixing was studied. With increasing number at H atoms in mols. of bipyridines, the corrosion inhibition coefficient and protection degree increased due to an increase in the ionization constant (i.e. increase in the amine basicity). The inhibiting effect of bipyridines was directly associated with their configuration. In bipyridine hydroderivs., ionization coefficients were different due to the mutual arrangement of amino groups in mols. The greater the distance between amino groups (adsorption centers) in the bipyridine hydroderiv. mol., the higher the basicity of the compound and, thus, the ionization constant, inhibiting coefficient, and protection degree. 4,4‘-Bipyridine  [553-26-4] and its hydroderivs. had the greatest inhibiting effect. This study involved multiple reactions and reactants, such as 3-(Piperidin-3-yl)pyridine (cas: 31251-28-2Category: piperidines).

3-(Piperidin-3-yl)pyridine (cas: 31251-28-2) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Bipiperidines. XX. Determination of the basicity of some bipiperidines was written by Forostyan, Yu. N.;Koval’chuk, B. V.;Efimova, E. I.. And the article was included in Zhurnal Obshchei Khimii in 1973.Application of 31251-28-2 The following contents are mentioned in the article:

Basicity values, pKa1 and pKa2, were determined for 8 bipiperidines and 4 piperidylpyridines. The values decreased as the distance between the N atoms decreased. This study involved multiple reactions and reactants, such as 3-(Piperidin-3-yl)pyridine (cas: 31251-28-2Application of 31251-28-2).

3-(Piperidin-3-yl)pyridine (cas: 31251-28-2) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Application of 31251-28-2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D₄ receptor agonists was written by Wang, Xueqing;Bhatia, Pramila A.;Daanen, Jerome F.;Latsaw, Steve P.;Rohde, Jeffrey;Kolasa, Teodozyi;Hakeem, Ahmed A.;Matulenko, Mark A.;Nakane, Masaki;Uchic, Marie E.;Miller, Loan N.;Chang, Renjie;Moreland, Robert B.;Brioni, Jorge D.;Stewart, Andrew O.. And the article was included in Bioorganic & Medicinal Chemistry in 2005.Electric Literature of C10H14N2 The following contents are mentioned in the article:

A series of 3-aryl piperidine analogs with 2-piperidinoalkylamino or 2-piperidinoalkyloxy fused bicyclic rings were prepared and found to be potent and efficacious human dopamine D₄ agonists. The synthesis and structure-activity relationship (SAR) studies that led to the identification of these compounds are discussed. This study involved multiple reactions and reactants, such as 3-(Piperidin-3-yl)pyridine (cas: 31251-28-2Electric Literature of C10H14N2).

3-(Piperidin-3-yl)pyridine (cas: 31251-28-2) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Electric Literature of C10H14N2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Synthesis of methyl 1-(3,4-dichlorobenzyl)hexahydro-2,3-dioxo-4-pyridinecarboxylate was written by Schwan, Thomas J.;Gray, Joseph E.;Wright, George C.. And the article was included in Journal of Pharmaceutical Sciences in 1979.Safety of Ethyl 2,3-dioxopiperidine-4-carboxylate The following contents are mentioned in the article:

Me 1-(3,4-dichlorbenzyl)hexahydro-2,3-dioxo-4-pyridinecarboxylate (I) was prepared by alkylation of Me hexahydro-2,3-dioxo-4-pyridinecarboxylate with α,3,4-trichlorotoluene. I was active against pathogenic yeast species, some dermatophytic fungi and Aspergillus niger. This study involved multiple reactions and reactants, such as Ethyl 2,3-dioxopiperidine-4-carboxylate (cas: 30727-21-0Safety of Ethyl 2,3-dioxopiperidine-4-carboxylate).

Ethyl 2,3-dioxopiperidine-4-carboxylate (cas: 30727-21-0) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Safety of Ethyl 2,3-dioxopiperidine-4-carboxylate

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Regioselective reduction of bipyridines was written by Plaquevent, Jean Christophe;Chichaoui, Ilhame. And the article was included in Tetrahedron Letters in 1993.Product Details of 31251-28-2 The following contents are mentioned in the article:

A method for the specific reduction of bipyridines through the use of the N-oxo derivatives is described. E.g., oxidation of 2,4′-bipyridine by m-chloroperbenzoic acid gave the N-oxo derivative, which was hydrogenated (H₂, Pd) to give 38% piperidinylpyridine I. This study involved multiple reactions and reactants, such as 3-(Piperidin-3-yl)pyridine (cas: 31251-28-2Product Details of 31251-28-2).

3-(Piperidin-3-yl)pyridine (cas: 31251-28-2) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Product Details of 31251-28-2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Bipiperidines. VI. Reaction of hexahydrobipyridines with chloroformates was written by Forostyan, Yu. N.;Efimova, E. I.. And the article was included in Zhurnal Organicheskoi Khimii in 1971.Name: 3-(Piperidin-3-yl)pyridine The following contents are mentioned in the article:

ClCO2R (R = Me, Et, Pr, Bu, iso-Bu, PhCH2) acylated 1′,2′,3′,4′,5′,6′-hexahydro-2,2′-, 3,3′-, 4,4′-, and 2′,3-bipyridines at the N of the piperidine ring, forming the corresponding alkyl pyridylpiperidine-1-carboxylates. This study involved multiple reactions and reactants, such as 3-(Piperidin-3-yl)pyridine (cas: 31251-28-2Name: 3-(Piperidin-3-yl)pyridine).

3-(Piperidin-3-yl)pyridine (cas: 31251-28-2) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Name: 3-(Piperidin-3-yl)pyridine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Mechanism of local anesthetic action. 1. Receptor problem was written by Schultz, Otto E.;Ziegler, A.. And the article was included in Pharmazie in 1970.COA of Formula: C8H11NO4 The following contents are mentioned in the article:

Furfuryl alc. was treated 1 hr at -5° with PBr3 and the product treated with MeNH2 and alc. NaI 72 hr at 100-20° to give I. Treatment of I with HBr-HOAc gave a ring-opened product which was cyclized with KOH to give 63% II. Similarly prepared were 10 other compounds including III, IV, V, VI, and VII. The local anesthetic activity of these compounds vs. procaine-HCl (III) was determined III had 80% of the VIII activity. The mechanism of local anesthetic activity is discussed. This study involved multiple reactions and reactants, such as Ethyl 2,3-dioxopiperidine-4-carboxylate (cas: 30727-21-0COA of Formula: C8H11NO4).

Ethyl 2,3-dioxopiperidine-4-carboxylate (cas: 30727-21-0) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.COA of Formula: C8H11NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Neonicotine and isomeric pyridylpiperidines was written by Smith, C. R.. And the article was included in Journal of the American Chemical Society in 1931.Category: piperidines The following contents are mentioned in the article:

cf. C. A. 18, 2006. Details are given for the isolation of neonicotine (尾-pyridyl-伪-piperidine) (I) from the reaction product of C₅H₅N, Na and O; I b₇₇₅ 280-1掳 and yields a picrate, m. 213掳 (con.); this is probably not identical with nicotimine, isolated by Pictet and Rotschky (Ber. 34, 696(1901)) from the nicotine alkaloids. Reduction of I gives 伪,尾-dipiperidyl, b. 269-70掳. Reduction of 伪,尾-dipyridyl gives isoneonicotine (伪-pyridyl-尾-piperidine), b₇₆₀ 282掳, whose picrate m. 217-8掳 (corrected). 伪,伪-Pyridylpiperidyl, b₇₅₅ 265-6掳, whose picrate m. 187掳; the NO derivative is an oil. Isonicotine (纬,纬-pyridylpiperidine) b₇₆₀ 292掳; the picrate m. 215-8掳 (decomposition); the NO derivative m. 112掳. Nicotidine (尾,尾-pyridylpiperidine) b. 284-5掳; picrate m. about 206掳. 尾-Pyridyl-纬-piperidine yields a picrate, m. 240掳. The ease of reduction by Sn and HCl of the dipyridyls is in the order 纬,纬-, 尾,纬, 伪,伪- and 尾,尾, the first being the most easily reduced. This study involved multiple reactions and reactants, such as 3-(Piperidin-3-yl)pyridine (cas: 31251-28-2Category: piperidines).

3-(Piperidin-3-yl)pyridine (cas: 31251-28-2) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising 伪-glucosidase inhibitors. The former are analogs of DNJ with an improved 伪-glucosidase inhibitory profile than that of DNJ. Boisson et al.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Synthesis and Structure-Activity Relationship Studies of Benzimidazole-4,7-dione-Based P2X3 Receptor Antagonists as Novel Anti-Nociceptive Agents was written by Bae, Jinsu;Kim, Yeo-Ok;Han, Xuehao;Yoon, Myung-Ha;Kim, Woong-Mo;Kim, Yong-Chul. And the article was included in Molecules in 2022.Product Details of 1019351-46-2 The following contents are mentioned in the article:

P2X3 receptors (P2X3R) are ATP-gated ion channels predominantly expressed in C- and Aδ-fiber primary afferent neurons and have been introduced as a novel therapeutic target for neurol. disorders, including neuropathic pain and chronic cough. Because of its localized distribution, antagonism of P2X3R has been thoroughly considered, and the avoidance of issues related to CNS side effects has been proven in clin. trials. In this article, benzimidazole-4,7-dione-based derivatives were introduced as a new chem. entity for the development of P2X3R antagonists. Starting from the discovery of a hit compound from the screening of 8364 random library compounds in the Korea Chem. Bank, which had an IC50 value of 1030 nM, studies of structure-activity and structure-property relationships enabled further optimization toward improving the antagonistic activities as well as the drug′s physicochem. properties, including metabolic stability. As for the results, the final optimized compound 14h was developed with an IC50 value of 375 nM at P2X3R with more than 23-fold selectivity vs. P2X2/3R, along with properties of metabolic stability and improved solubility In neuropathic pain animal models evoked by either nerve ligation or chemotherapeutics in male Sprague-Dawley rats, compound 14h showed anti-nociceptive effects through an increase in the mech. withdrawal threshold as measured by von Frey filament following i.v. administration. This study involved multiple reactions and reactants, such as Methyl 4-aminopiperidine-1-carboxylate (cas: 1019351-46-2Product Details of 1019351-46-2).

Methyl 4-aminopiperidine-1-carboxylate (cas: 1019351-46-2) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Product Details of 1019351-46-2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem