Tag: 100-200

Zhang, Zhe; Zhang, Zhao-Sheng; Wang, Xiao; Xi, Gao-Lei; Jin, Zhen; Tang, You-Zhi published an article in 2021. The article was titled 《A click chemistry approach to pleuromutilin derivatives, evaluation of anti-MRSA activity and elucidation of binding mode by surface plasmon resonance and molecular docking》, and you may find the article in Journal of Enzyme Inhibition and Medicinal Chemistry.Quality Control of 2-(Piperidin-4-yl)ethanol The information in the text is summarized as follows:

A series of pleuromutilin analogs containing substituted 1,2,3-triazole moieties I [R1 = Me, Ph, 3-fluorophenyl, etc.] and II [R2 = R3 = Me, cyclohexyl, etc.] were designed, synthesized and assessed for their in vitro antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA). Initially, the in vitro antibacterial activities of these derivatives against 4 strains of S. aureus (MRSA ATCC 43300, ATCC 29213, AD3, and 144) were tested by the broth dilution method. Most of the synthesized pleuromutilin analogs displayed potent activities. Among them, compounds I [R1 = 2-methylphenyl, 2-nitrophenyl, 4-nitrophenyl] (MIC = 0.5∼1 μg/mL) showed the most effective antibacterial activity and their anti-MRSA activity were further studied by the time-killing kinetics approach. Binding mode investigations by surface plasmon resonance (SPR) with 50S ribosome revealed that the selected compounds all showed obvious affinity for 50S ribosome (KD = 2.32 x 10-8∼5.10 x 10-5 M). Subsequently, the binding of compounds I [R1 = 2-methylphenyl, 4-nitrophenyl] to the 50S ribosome was further investigated by mol. modeling. Compound I [R1 = 2-methylphenyl] had a superior docking mode with 50S ribosome, and the binding free energy of compound was calculated to be -12.0 kcal/mol. In the experiment, the researchers used many compounds, for example, 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Quality Control of 2-(Piperidin-4-yl)ethanol)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAKQuality Control of 2-(Piperidin-4-yl)ethanol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The author of 《Design, synthesis, in vitro and in vivo evaluation of benzylpiperidine-linked 1,3-dimethylbenzimidazolinones as cholinesterase inhibitors against Alzheimer’s disease》 were Mo, Jun; Chen, Tingkai; Yang, Hongyu; Guo, Yan; Li, Qi; Qiao, Yuting; Lin, Hongzhi; Feng, Feng; Liu, Wenyuan; Chen, Yao; Liu, Zongliang; Sun, Haopeng. And the article was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020. Recommanded Product: 39546-32-2 The author mentioned the following in the article:

Cholinesterase inhibitor plays an important role in the treatment of patients with Alzheimer’s disease (AD). Herein, we report the medicinal chem. efforts leading to a new series of 1,3-dimethylbenzimidazolinone derivatives Among the synthesized compounds, and showed submicromolar IC50 values (, eeAChE IC50 = 0.39 ± 0.11μM; , eqBChE IC50 = 0.16 ± 0.04μM) towards acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Kinetic and mol. modeling studies revealed that and act in a competitive manner. and showed neuroprotective effect against H2O2-induced oxidative damage on PC12 cells. This effect was further supported by their antioxidant activity determined in a DPPH assay in vitro. Morris water maze test confirmed the memory amelioration effect of the two compounds in a scopolamine-induced mouse model. Moreover, the hepatotoxicity of and was lower than tacrine. In summary, these data suggest and are promising multifunctional agents against AD. The results came from multiple reactions, including the reaction of Piperidine-4-carboxamide(cas: 39546-32-2Recommanded Product: 39546-32-2)

Piperidine-4-carboxamide(cas: 39546-32-2) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Recommanded Product: 39546-32-2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Sternfeld, Francine; Baker, Raymond; Broughton, Howard B.; Guiblin, Alexander R.; Jelley, Richard A.; Matassa, Victor G.; Reeve, Austin J.; Beer, Margaret; Stanton, Josephine a. published their research in Bioorganic & Medicinal Chemistry Letters on August 6 ,1996. The article was titled 《The chemical evolution of N,N-dimethyl-2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethylamine (L-741,604) and analogs: potent and selective agonists for 5-HT1D receptors》.Reference of Methyl 2-(1-methylpiperidin-4-yl)acetate The article contains the following contents:

Optimization of a series of 5-(heterocyclyl)tryptamines led to the identification of the sym. substituted, N-4 linked 1,2,4-triazole as the best indole C-5 substituent for 5-HT1D receptor affinity and selectivity. The triazole I is the most potent and selective, orally bioavailable, 5-HT1D receptor agonist identified to date, showing an order of magnitude greater potency than the clin. compound sumatriptan with improved subtype selectivity. The experimental part of the paper was very detailed, including the reaction process of Methyl 2-(1-methylpiperidin-4-yl)acetate(cas: 95533-25-8Reference of Methyl 2-(1-methylpiperidin-4-yl)acetate)

Methyl 2-(1-methylpiperidin-4-yl)acetate(cas: 95533-25-8) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Reference of Methyl 2-(1-methylpiperidin-4-yl)acetate

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Ge, Teng; Jin, Xiaoli; Cao, Jian; Chen, Zhuohua; Xu, Yixue; Xie, Haiquan; Su, Fengyun; Li, Xin; Lan, Qing; Ye, Liqun published their research in Journal of the Taiwan Institute of Chemical Engineers on December 31 ,2021. The article was titled 《Giant enhanced photocatalytic H2O2 production over hollow hexagonal prisms carbon nitride》.Reference of Triacetonamine The article contains the following contents:

H2O2, as a green and environmentally friendly oxidant, has been widely used in our daily life and industrial production It is of epoch-making significance to develop highly efficient photocatalysts for producing H2O2. In recent years, g-C3N4 has received much attention due to its high chem. stability, environmental friendliness and suitable energy band structure. However, some shortcomings including the fast recombination of photogenerated electron-hole pairs and small sp. surface area in traditional 2D g-C3N4 seriously impede its photocatalytic performance for the production of H2O2.1D hollow nanostructures possess intriguing physicochem. properties and are adopted to overcome the intrinsic shortcomings of g-C3N4. Herein, g-C3N4 with a hollow hexagonal prism structure (CN-HP) is prepared to produce H2O2. It is characterized by XRD, XPS, SEM, HRTEM, ESR and DRS. BET, PL spectra, photocurrent and EIS are used to explain the enhanced photocatalytic performance. Compared with traditional 2D g-C3N4, the sp. surface area of CN-HP increases to 41.513 m2/g, providing more active sites. Meanwhile, its hollow tubular structure can enhance the migration of photogenerated electrons to the catalyst surface, and electrons with a longer lifetime can participate in photocatalytic reactions to achieve high efficiency. The yield of H2O2 production can up to 4.08 μmol over CN-HP in 40 min, which is about 7 times higher than that of traditional 2D g-C3N4, and the apparent quantum efficiency (AQE) of H2O2 production at 420 nm is 2.41%. This research provides a valuable reference for the development of green materials for efficient photocatalytic production of H2O2. In addition to this study using Triacetonamine, there are many other studies that have used Triacetonamine(cas: 826-36-8Reference of Triacetonamine) was used in this study.

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Reference of Triacetonamine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

《Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer》 was written by Bradbury, Robert H.; Acton, David G.; Broadbent, Nicola L.; Brooks, A. Nigel; Carr, Gregory R.; Hatter, Glenn; Hayter, Barry R.; Hill, Kathryn J.; Howe, Nicholas J.; Jones, Rhys D. O.; Jude, David; Lamont, Scott G.; Loddick, Sarah A.; McFarland, Heather L.; Parveen, Zaieda; Rabow, Alfred A.; Sharma-Singh, Gorkhn; Stratton, Natalie C.; Thomason, Andrew G.; Trueman, Dawn; Walker, Graeme E.; Wells, Stuart L.; Wilson, Joanne; Wood, J. Matthew. Recommanded Product: 50461-59-1 And the article was included in Bioorganic & Medicinal Chemistry Letters on April 1 ,2013. The article conveys some information:

Removal of the basic piperazine nitrogen atom, introduction of a solubilising end group and partial reduction of the triazolopyridazine moiety in the previously-described lead androgen receptor downregulator 6-[4-(4-cyanobenzyl)piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine (1) addressed hERG and phys. property issues, and led to clin. candidate 6-(4-{4-[2-(4-acetylpiperazin-1-yl)ethoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine (12), designated AZD3514, that is being evaluated in a Phase I clin. trial in patients with castrate-resistant prostate cancer. In the experimental materials used by the author, we found 4-(Pyridin-3-yl)piperidin-4-ol(cas: 50461-59-1Recommanded Product: 50461-59-1)

4-(Pyridin-3-yl)piperidin-4-ol(cas: 50461-59-1) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. Recommanded Product: 50461-59-1

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Kostrzewa, Tomasz; Wolosewicz, Karol; Jamrozik, Marek; Drzezdzon, Joanna; Sieminska, Julia; Jacewicz, Dagmara; Gorska-Ponikowska, Magdalena; Kolaczkowski, Marcin; Lazny, Ryszard; Kuban-Jankowska, Alicja published their research in International Journal of Molecular Sciences in 2021. The article was titled 《Curcumin and Its New Derivatives: Correlation between Cytotoxicity against Breast Cancer Cell Lines, Degradation of PTP1B Phosphatase and ROS Generation》.Electric Literature of C6H11NO The article contains the following contents:

Breast cancer is the most common cancer of women-it affects more than 2 million women worldwide. PTP1B phosphatase can be one of the possible targets for new drugs in breast cancer therapy. In this paper, we present new curcumin derivatives featuring a 4-piperidone ring as PTP1B inhibitors and ROS inducers. We performed cytotoxicity anal. for twelve curcumin derivatives against breast cancer MCF-7 and MDA-MB-231 cell lines and the human keratinocyte HaCaT cell line. Furthermore, because curcumin is a known antioxidant, we assessed antioxidant effects in its derivatives For the most potent cytotoxic compounds, we determined intracellular ROS and PTP1B phosphatase levels. Moreover, for curcumin and its derivatives, we performed real-time microscopy to observe the photosensitizing effect. Finally, computational anal. was performed for the curcumin derivatives with an inhibitory effect against PTP1B phosphatase to assess the potential binding mode of new inhibitors within the allosteric site of the enzyme. We observed that two tested compounds are better anticancer agents than curcumin. Moreover, we suggest that blocking the -OH group in phenolic compounds causes an increase in the cytotoxicity effect, even at a low concentration Furthermore, due to this modification, a higher level of ROS is induced, which correlates with a lower level of PTP1B. The results came from multiple reactions, including the reaction of 1-Methyl-4-piperidone(cas: 1445-73-4Electric Literature of C6H11NO)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Electric Literature of C6H11NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Liu, Li; Li, Yuxin; Pang, Yaqian; Lan, Yeqing; Zhou, Lixiang published their research in Chemical Engineering Journal (Amsterdam, Netherlands) on December 1 ,2020. The article was titled 《Activation of peroxymonosulfate with CuCo2O4@kaolin for efficient degradation of phenacetin》.Quality Control of Triacetonamine The article contains the following contents:

CuCo2O4@kaolin was successfully synthesized by a sol-gel method and used as a heterogeneous catalyst to activate peroxymonosulfate (PMS) for the degradation of phenacetin (PNT). The results demonstrated that 10 mg/L PNT was completely decomposed by 1 mM PMS activated with 0.1 g/L CuCo2O4@kaolin within 15 min at initial pH 7. CuCo2O4@kaolin exhibited the best excellent catalytic performance among the tested catalysts, and the pseudo-first-order rate constants of PNT degradation were CuCo2O4@kaolin (0.40 min-1) > CuCo2O4 (0.22 min-1) > Co3O4@kaolin (0.10 min-1) > CuO@kaolin (0.08 min-1) > kaolin (0.02 min-1). CuCo2O4@kaolin also possessed superior stability, and the degradation efficiency of PNT declined from 100% in the first round to 80% in the fourth round. Nevertheless, a simple calcinating treatment (20 min) after the third round could restore its catalytic activity substantially and 95% removal of PNT was realized, 15% higher compared to without treatment. ·OH, SO4·-, and 1O2 were the reactive oxygen species driving the PNT degradation Based on the results mentioned above, characterizations of CuCo2O4@kaolin, and intermediates of PNT degradation, the possible pathways and underlying mechanisms of the PNT degradation in the CuCo2O4@kaolin/PMS system were deduced. CuCo2O4@kaolin/PMS had a universal degradation potential toward various organic pollutants, and the degradation efficiencies of sulfisoxazole, p-nitrophenol, chloramphenicol, and 2,4,6-Trichlorophenol reached 95-100% within 5-45 min. Thus, this work provides a novel and efficient PMS activator through an eco-friendly synthetic route, and it may be put into practice to degrade organic matter in wastewater.Triacetonamine(cas: 826-36-8Quality Control of Triacetonamine) was used in this study.

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Quality Control of Triacetonamine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Liao, Chenzhong; Nicklaus, Marc C. published their research in Journal of Chemical Information and Modeling on December 31 ,2009. The article was titled 《Comparison of Nine Programs Predicting pKa Values of Pharmaceutical Substances》.Reference of Methyl 1-methylpiperidine-3-carboxylate The article contains the following contents:

Knowledge of the possible ionization states of a pharmaceutical substance, embodied in the pKa values (logarithm of the acid dissociation constant), is vital for understanding many properties essential to drug development. We compare nine com. available or free programs for predicting ionization constants Eight of these programs are based on empirical methods: ACD/pKa DB 12.0, ADME Boxes 4.9, ADMET Predictor 3.0, Epik 1.6, Marvin 5.1.4, Pallas pKalc Net 2.0, Pipeline Pilot 5.0, and SPARC 4.2; one program is based on a quantum chem. method: Jaguar 7.5. We compared their performances by applying them to 197 pharmaceutical substances with 261 carefully determined and highly reliable exptl. pKa values from a literature source. The programs ADME Boxes 4.9, ACD/pKa DB 12.0, and SPARC 4.2 ranked as the top three with mean absolute deviations of 0.389, 0.478, and 0.651 and r2 values of 0.944, 0.908, and 0.894, resp. ACD/pKa DB 12.0 predicted all sites, whereas ADME Boxes 4.9 and SPARC 4.2 failed to predict 5 and 18 sites, resp. The performance of the quantum chem.-based program Jaguar 7.5 was not as expected, with a mean absolute deviation of 1.283 and an r2 value of 0.579, indicating the potential for further development of this type of approach to pKa prediction. In the part of experimental materials, we found many familiar compounds, such as Methyl 1-methylpiperidine-3-carboxylate(cas: 1690-72-8Reference of Methyl 1-methylpiperidine-3-carboxylate)

Methyl 1-methylpiperidine-3-carboxylate(cas: 1690-72-8) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Reference of Methyl 1-methylpiperidine-3-carboxylate

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Ishag, Abd Elaziz Sulieman Ahmed; Abdelbagi, Azhari Omer; Hammad, Ahmed Mohammed Ali; Elsheikh, Elsiddig Ahmed Elmustafa; Hur, Jang-Hyun published an article on February 28 ,2019. The article was titled 《Photodegradation of chlorpyrifos, malathion, and dimethoate by sunlight in the Sudan》, and you may find the article in Environmental Earth Sciences.Application In Synthesis of Triacetonamine The information in the text is summarized as follows:

The potential of sunlight photolysis in remediation of pesticide-polluted soils in Sudan was studied. Chlorpyrifos, malathion and dimethoate, common pollutants, were exposed to sunlight over glass and soil surfaces with periodic samples drawn for GC and GC-MS anal. Photo-degradation followed a biphasic model. Alpha half-lives of direct photolysis over glass surface range between 1.99 and 9.36 days while the range in soil surfaces is 1.88-10.77 days. Resp. values for indirect photolysis with βcarotene are 0.96-2.40 days whereas for benzophenone are 0.38-2.37 days (not including malathion as starting material was completely lost after 3 days). Values for soil β-carotene sensitized photolysis are 0.85-4.02 days while resp. values for soil benzophenone sensitized photolysis are 0.88-3.74 days. Metrol. factors did not have a significant impact on photolysis rates. No photoproducts detected in direct photolysis. However, many photoproducts were detected on the indirect sets. Photo-degradation efficiency can be ordered as; benzophenone > β-carotene > direct exposure. In the experiment, the researchers used many compounds, for example, Triacetonamine(cas: 826-36-8Application In Synthesis of Triacetonamine)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Application In Synthesis of Triacetonamine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Synthetic Route of C9H17NOOn March 24, 2020, Tanaka, Susumu; Enoki, Toshiaki; Imoto, Hiroaki; Ooyama, Yousuke; Ohshita, Joji; Kato, Takuji; Naka, Kensuke published an article in Macromolecules (Washington, DC, United States). The article was 《Highly Efficient Singlet Oxygen Generation and High Oxidation Resistance Enhanced by Arsole-Polymer-Based Photosensitizer: Application as a Recyclable Photooxidation Catalyst》. The article mentions the following:

Photosensitizers have attracted considerable attention in various fields such as organic synthesis and medical care. For the development of high-performance photosensitizers, highly efficient and persistent singlet oxygen generators (1O2) having a high oxidation tolerance are strongly required. This study presents a detailed investigation of dithieno[3,2-b:2′,3′-d]arsole-fluorene copolymer for its 1O2 generation ability and application as a photooxidation catalyst in vital organic reactions. Photoirradiation of an air-saturated solution of the polymer generates 1O2, which was detected by 1O2 scavengers such as dihydronaphthoquinone and diphenylisobenzofuran. The polymer photosensitizer was completely stable in the presence of the strong oxidant 1O2. The photosensitizer showed the highest quantum yield of 1O2 generation (Φ = 0.54) in single-component main-chain type π-conjugated polymers. The quantum yield of the arsenic-free analog of the polymer-bithiophene-fluorene copolymer-was significantly lower (Φ = 0.14), suggesting that the heavy-atom effect of arsenic can improve the efficiency of intersystem crossing (ISC) from the singlet excited state to the triplet excited state of the photosensitizer. In addition, when utilized as a recyclable photocatalyst for the oxidation reaction, the photosensitizer exhibited excellent oxidation resistance without losing its recognizable catalytic activity. Finally, we demonstrated the release of 1O2 into the air by a film of the present polymer. Persistent 1O2 generation was observed on film irradiation without polymer decomposition These results suggested that the polymer exhibited excellent oxidation resistance in solution as well as in the solid state. The present mol. design concept of the photosensitizer using the main group element can facilitate the development of further functional optical materials. In the experimental materials used by the author, we found Triacetonamine(cas: 826-36-8Synthetic Route of C9H17NO)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Synthetic Route of C9H17NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem