Tag: 100-200

Reference of TriacetonamineOn March 1, 2022, Wei, Ying; Lu, Guanglu; Xie, Dongrun; Sun, Tianyi; Liu, Yu; Zhang, Ying; An, Jiutao; Li, Menghong; Guo, He published an article in Chemical Engineering Journal (Amsterdam, Netherlands). The article was 《Degradation of enrofloxacin in aqueous by DBD plasma and UV: Degradation performance, mechanism and toxicity assessment》. The article mentions the following:

Enrofloxacin (ENRO) as a highly toxic antibiotic poses great threats to human health and environmental safety. In this study, a novel technol. of coupling dielec. barrier discharge (DBD) and UV was investigated to efficiently degrade ENRO in aqueous, and had a higher degradation rate. The ENRO degradation rate achieved approx. 93.9% at 30 min, and approx. 1.20 g kWh-1 of energy yield (G50) was observed for the combined system. The addition of H2O2 and K2S2O4 improved the ENRO degradation due to the generation of ·OH and ·SO42-. In the presence of NO3-, the ENRO degradation played a tendency to promote first and then decrease, and the presence of SO42-resulted in the pos. effect, while the neg. effect was shown in the presence of Cl- and CO32-. The trapping experiment indicated that ·OH played an important part in the ENRO degradation The addition of UV into the DBD system decreased H2O2 concentration in deionized water, and increased ·OH concentration The DFT anal. showed the degradation mechanisms of ENRO at a mol. level. The degradation of ENRO mainly involved the oxidation of the piperazine group, the removal of Et acetate and the substitution of the F atom. The toxicity of ENRO and its degradation intermediates was evaluated. After reading the article, we found that the author used Triacetonamine(cas: 826-36-8Reference of Triacetonamine)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Reference of Triacetonamine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Reference of TriacetonamineOn March 5, 2022, Wang, Gen; Ge, Lei; Liu, Zhuoyue; Zhu, Xiurong; Yang, Shengjiong; Wu, Kun; Jin, Pengkang; Zeng, Xiangkang; Zhang, Xiwang published an article in Chemical Engineering Journal (Amsterdam, Netherlands). The article was 《Activation of peroxydisulfate by defect-rich CuO nanoparticles supported on layered MgO for organic pollutants degradation: An electron transfer mechanism》. The article mentions the following:

Heterogeneous activation of peroxydisulfate (PDS) by transition metal oxides offers a promising strategy for organic pollutants removal but suffers from low electron transfer efficiency. Herein, layered MgO supported CuO nanoparticles was prepared by thermal conversion of metal-phenolic networks of Cu2+/Mg2+ and tannic acid. CuO nanoparticles (≈2 nm) were spatial monodispersed on layered MgO, inducing the formation of electron deficient Cu3+ and surface oxygen vacancies and thus facilitated adsorption and activation of PDS. The electron-rich CuO/MgO hybrid catalysts manifested good catalytic performance of PDS activation for organic pollutants removal. At 0.18 g/L of CuO/MgO hybrid catalyst and 0.2 mM of PDS, complete removal of bisphenol A (BPA) was achieved with a high kinetic constant (0.1 min-1, 50 min). Quenching experiments, ESR tests, PDS decomposition behaviors, electrochem. anal. and in situ ATR-FTIR and Raman spectroscopy revealed a nonradical pathway of electron transfer for PDS activation. The CuO/MgO hybrid catalysts exhibited wide working pH range from 3 to 11, selective oxidation capability, good resistance to halide ion and high utilization efficiency of PDS, and thus would be a promising candidate for wastewater remediation. The experimental part of the paper was very detailed, including the reaction process of Triacetonamine(cas: 826-36-8Reference of Triacetonamine)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Reference of Triacetonamine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

COA of Formula: C7H11NO4On September 15, 1993 ,《Characterization of [35S]lanthionine ketimine specific binding to bovine brain membranes》 was published in Biochemical and Biophysical Research Communications. The article was written by Dupre, S.; Fontana, M.; Costa, M.; Pecci, L.; Ricci, G.; Cavallini, D.. The article contains the following contents:

[35S]Lanthionine ketimine binds specifically and with high affinity to bovine brain membranes. This binding has been studied in detail. It is reversible, not occurring at an uptake site or at a metabolizing enzyme and depending only weakly on ionic strength; it is affected by thiol reagents. [35S]Lanthionine ketimine specific binding is displaced only by other ketimines and by catecholamines, but not by more selective adrenergic ligands; binding parameters are reported. [3H]Adrenaline but not [3H]dihydroalprenolol is partially displaced by lanthionine ketimine. With bovine brain preparations a significant stimulation of basal adenylate cyclase activity by lanthionine ketimine is observedCis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1COA of Formula: C7H11NO4) was used in this study.

Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.COA of Formula: C7H11NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

《The action of tertiary and quaternary arecaidine and dihydroarecaidine esters on the guinea pig isolated ileum》 was published in British Journal of Pharmacology and Chemotherapy in 1966. These research results belong to Gloge, Holger; Luellmann, Heinz; Mutschler, Erich. Application of 1690-72-8 The article mentions the following:

A homologous series of tertiary and quaternary arecaidine esters (methyl to isobutyl), as well as the corresponding dihydrocompds., were investigated quant. on the isolated ileum of the guinea pig. The tertiary arecaidine esters are agonists. Highest activities (effective doses) are observed for the Et ester (E.D.50 = 1.5 × 10-4M) and for arecoline, the Me ester (E.D.50 = 5.8 × 10-8M). Esters with a longer side-chain show considerably lower activity. The intrinsic activities of arecaidine Et ester, arecoline, and dimethylaminoethyl acetate are higher than that of acetylcholine. Hydrogenation of the double bond in the ring markedly reduces the affinity and intrinsic activity of the tertiary arecaidine esters. Hydrogenated esters with a longer side-chain act as inhibitors. Quaternization by means of iodomethylation exerts varying influences on the intrinsic activities of arecaidine esters. In the case of the Me ester the intrinsic activity is somewhat reduced whereas that of the Et ester considerably decreases upon iodomethylation, thus yielding a partial antagonist. Similar transformation of esters with a longer side-chain leads to a complete loss of intrinsic activity. The quaternized compounds thus obtained are inhibitors with atropine-like action. Iodoethylation and iodopropylation even abolish the intrinsic activities of esters with a short side-chain. Hydrogenation of the double bond in the ring of the quaternary compounds similarly diminishes the activity as observed for the tertiary compounds For aliphatic N atoms, quaternization is essential in order to enable a reaction with the acetylcholine receptors of the muscarine type. In the case of ring N atoms, the tertiary protonated form is necessary for obtaining a high intrinsic activity upon combination with the receptor mol. In arecaidine esters, quaternization of the ring N atom reduces or even destroys intrinsic activity, in proportion to the length of the ester side-chain. The experimental process involved the reaction of Methyl 1-methylpiperidine-3-carboxylate(cas: 1690-72-8Application of 1690-72-8)

Methyl 1-methylpiperidine-3-carboxylate(cas: 1690-72-8) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Application of 1690-72-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

《A simple, robust and efficient structural model to predict CO2 absorption for different amine solutions: Concern to design new amine compounds》 was published in Journal of Environmental Chemical Engineering in 2020. These research results belong to Raznahan, Mohammad Moein; Riahi, Siavash; Mousavi, Seyed Hamed. Application In Synthesis of 2-(Piperidin-4-yl)ethanol The article mentions the following:

The absorption capacity (AC) and absorption rate (AR) are considered as the two main characteristics in choosing the great amine solutions for carbon dioxide absorption. However, selecting the proper amine-based solution on a vast number of exptl. procedures is unaffordable regarding cost and time. Accordingly, studying and modeling amine structures and discovering the relationship between structural parameters and the AC and AR values of amine compounds are of great necessity. The Quant. Structure-Property Relationship (QSPR) method, which is considered as an efficient procedure, is used for predicting carbon dioxide absorption by amine solutions The present study was performed on two different groups of amine solutions, including chained and non-ring-shaped structures for group 1 and major ring-shaped structures for group 2. Then, linear and nonlinear models were applied to create QSPR models, resp. The values of the square of the correlation coefficient (R2) for linear and nonlinear models were 0.753 and 0.985, as well as 0.895 and 0.954 for groups 1 and 2, resp. The results demonstrated that applying a nonlinear model is more efficient and accurate than the linear model for predicting absorption. Further, the prediction of the CO2 absorption value is achievable with high precision for groups 1 and 2 using only 1 and 2 descriptors, resp. In this paper, new amine mols. were designed based on their primary structures and the reported descriptor. Finally, the constructed compounds were found to have better AR and AC compared to initial structures. In the experimental materials used by the author, we found 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Application In Synthesis of 2-(Piperidin-4-yl)ethanol)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.Application In Synthesis of 2-(Piperidin-4-yl)ethanol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The author of 《Design, synthesis, and anticonvulsant effects evaluation of nonimidazole histamine H3 receptor antagonists/inverse agonists containing triazole moiety》 were Song, Mingxia; Yan, Rui; Zhang, Yanhui; Guo, Dongfu; Zhou, Naiming; Deng, XianQing. And the article was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020. Category: piperidines The author mentioned the following in the article:

Histamine H3 receptors (H3R) antagonists/inverse agonists are becoming a promising therapeutic approach for epilepsy. In this article, novel nonimidazole H3R antagonists/inverse agonists have been designed and synthesized via hybriding the H3R pharmacophore (aliphatic amine with propyloxy chain) with the 1,2,4-triazole moiety as anticonvulsant drugs. The majority of antagonists/inverse agonists prepared here exerted moderate to robust activities in cAMP-response element (CRE) luciferase screening assay. 1-(3-(4-(3-Phenyl-4H-1,2,4-triazol-4-yl)phenoxy)propyl)piperidine () and 1-(3-(4-(3-(4-chlorophenyl)-4H-1,2,4-triazol-4-yl)phenoxy)propyl)piperidine displayed the highest H3R antagonistic activities, with IC50 values of 7.81 and 5.92 nM, resp. Meanwhile, the compounds with higher H3R antagonistic activities exhibited protection for mice in maximal electroshock seizure (MES)-induced convulsant model. Moreover, the protection of against the MES induced seizures was fully abrogated when mice were co-treated with RAMH, a CNS-penetrant H3R agonist, which suggested that the potential therapeutic effect of was through H3R. These results indicate that the attempt to find new anticonvulsant among H3R antagonists/inverse agonists is practicable. In addition to this study using Piperidine-4-carboxamide, there are many other studies that have used Piperidine-4-carboxamide(cas: 39546-32-2Category: piperidines) was used in this study.

Piperidine-4-carboxamide(cas: 39546-32-2) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2022,Liu, Xiaoxiao; Wei, Wei; Yang, Yunfei; Li, Yujiao; Li, Yao; Xu, Shicheng; Dong, Yanfeng; He, Ronghuan published an article in Chemical Engineering Journal (Amsterdam, Netherlands). The title of the article was 《A porous membrane electrolyte enabled by poly(biphenyl piperidinium triphenylmethane) for dendrite-free zinc anode with enhanced cycling life》.Product Details of 1445-73-4 The author mentioned the following in the article:

Aqueous zinc-ion batteries show great advantages as the sustainable energy storage devices, but suffer from inferior cycling life and low energy d. due to the notorious zinc dendrites and possible side reactions in aqueous electrolytes. Herein, we propose a zinc-ions (Zn2+) soaked porous membrane electrolyte (GF/PBPT) by incorporating poly(biphenyl piperidinium triphenylmethane) (PBPT) into glass fiber (GF) via non-solvent-induced phase separation The PBPT was synthesized via a super-acid catalyzed polymerization reaction. The fabricated membrane electrolyte containing PBPT of 42 wt% (GF/PBPT-42%) exhibits suitable pores and reasonable mech. robustness of 4.24 MPa. Moreover, the abundant tertiary amines on PBPT backbones have specific affinity to Zn2+, which benefits the uniform Zn2+ flux through the membrane electrolyte. As a result, the electrolyte of GF/PBPT-42% greatly facilitates dendrite-free Zn anode and enables the Zn/Zn cell to deliver a superior cycling life over 1540 h at 0.5 mA cm-2 at room temperature (RT). In addition to be used in the Zn/Zn cells, the GF/PBPT-42% membrane has been demonstrated its application as the electrolyte in the Zn/MnO2 cell with enhanced cycling stability at both RT and -10 °C. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-piperidone(cas: 1445-73-4Product Details of 1445-73-4)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Product Details of 1445-73-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The author of 《Potential multifunctional agents with anti-hepatoma and anti-inflammation properties by inhibiting NF-κB activation》 were Su, Chang-Ming; Hou, Gui-Ge; Wang, Chun-Hua; Zhang, Hong-Qin; Yang, Cheng; Liu, Mei; Hou, Yun. And the article was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2019. Synthetic Route of C6H11NO The author mentioned the following in the article:

Inhibition of NF-κB signalling has been demonstrated as a therapeutic option in treating inflammatory diseases and cancers. Herein, we synthesized novel dissym. 3,5-bis(arylidene)-4-piperidones (BAPs, 83-102 ) and characterized fully. MTT and ELISA assay were performed to screen the anti-hepatoma and anti-inflammation properties. 96(I) showed the most potential bioactivity. I could promote HepG2 apoptosis through up-regulating the expression of C-Caspase-3 and Bax, down-regulating the expression of Bcl-2, while markedly inhibit LPS or TNF-α-induced activation of NF-κB through both inhibiting the phosphorylation of IκBα and p65, and preventing the p65 nuclear translocation to exhibit both anti-hepatoma and anti-inflammatory activities. Mol. docking verified that simulated I can effectively bond to the active site of Bcl-2 and NF-κB/p65 proteins. I inhibited xenografts growth by reducing the expression of TNF-α and Bcl-2 in the tumor tissue. This study suggested that I could be developed as a potential multifunctional agent for treatment of inflammatory diseases and cancers. The results came from multiple reactions, including the reaction of 1-Methyl-4-piperidone(cas: 1445-73-4Synthetic Route of C6H11NO)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Synthetic Route of C6H11NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Sun, Qianqian; Liu, Bin; Wang, Zhao; Feng, Lili; Zhao, Ruoxi; Dong, Shuming; Dong, Yushan; Zhong, Lei; Gai, Shili; Yang, Piaoping published their research in Chemical Engineering Journal (Amsterdam, Netherlands) on December 1 ,2021. The article was titled 《H2O2/O2 self-supplementing and GSH-depleting Ca2+ nanogenerator with hyperthermia-triggered, TME-responsive capacities for combination cancer therapy》.Synthetic Route of C9H17NO The article contains the following contents:

The tumor microenvironment (TME) is complex in composition and unique in nature, and is closely related to the growth, invasion and metastasis of tumor cells. Improving and remodeling the TME to return it to a normalized state can fundamentally disrupt the environment and/or nutrient supply on which tumor cells depend. To achieve this goal, based on the unique physicochem. properties and biol. effects of CaO2, we designed and constructed a Ca2+ nanogenerator (named as CaO2-Cu/ICG@PCM) that enables H2O2/O2 self-supplementation and GSH depletion. The 808 nm laser induces the heat generation of photosensitizer indocyanine green (ICG) to initiate a series of reactions, followed by the production of copper ions, H2O2, O2 and large amounts of Ca2+, which can eventually lead to the combined treatment of photodynamic therapy (PDT), chemodynamic therapy (CDT) and calcium overload. Addnl., the reaction process is accompanied by the generation of Ca(OH)2, which greatly improves the acidic environment of TME and effectively promotes the oxidation process of GSH by H2O2, achieving the purpose of remodeling TME. It is worth mentioning that a large amount of free Ca2+ accumulating in tumor cells can rapidly initiate the process of calcium overload and calcification, which can not only play a role in tumor suppression, but also assist CT imaging to detect the effect of treatment. Thus, CaO2-Cu/ICG@PCM could be a promising candidate for bioimaging and tumor therapy. In the experimental materials used by the author, we found Triacetonamine(cas: 826-36-8Synthetic Route of C9H17NO)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Synthetic Route of C9H17NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Huang, Zhiyan; Wang, Tenglu; Shen, Minxian; Huang, Zhujian; Chong, Yunxiao; Cui, Lihua published their research in Chemical Engineering Journal (Amsterdam, Netherlands) on August 1 ,2019. The article was titled 《Coagulation treatment of swine wastewater by the method of in-situ forming layered double hydroxides and sludge recycling for preparation of biochar composite catalyst》.Category: piperidines The article contains the following contents:

In order to achieve enhanced treatment of swine wastewater as well as resource recycle, in this work, we applied coagulation treatment on swine wastewater by adding Fe and Mg ions, MgFe layered double hydroxides (LDHs) was yielded during coagulation process and the coagulation sludge was recycled to prepare biochar composite catalyst. The removal rates of total phosphorus (TP) and COD (COD) by Mg-Fe coagulation could achieve 82.55% and 98.51%, which is higher than that by coagulation with individual Mg2+ or individual Fe3+. Finely dispersed MgFe-LDHs flocculation was formed during the coagulation process and was embedded within zoogloea, suspended particles, organic matters, etc. The obtained coagulation sludge was recycled to prepare biochar composite catalyst by oxygen-limited pyrolysis. Redox reaction of iron compounds and electron shuttles capacity of biochar in the catalyst could activate potassium peroxymonosulfate (PMS) to generate ·OH, ·OOH and 1O2, which was responsible for catalysis potential. The as-prepared biochar composite catalyst showed satisfactory catalytic degradation capacity on tylosin and rhodamine B (pH value varied from 3 to 10), and the maximum degradation rate achieved 92.2% for tylosin and 81.9% for rhodamine B (RhB). Coagulation treatment of swine wastewater and in-situ formed layered double hydroxides recycling was suitable in wastewater treatment and resource recycling, of which the degradation rates of RhB were above 83% after five cycling experiments In general, the combined process exhibits great potential for the deep treatment of swine wastewater and resource recycling for sludge. In the part of experimental materials, we found many familiar compounds, such as Triacetonamine(cas: 826-36-8Category: piperidines)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem