Tag: 100-200

In 2016,Babu, J. Sree Ram; Sankar, T. Ravi; Babu, K. Sudhakar; Latha, J. published 《Synthesis, characterization and biological evaluation of some novel disubstituted heterocyclic derivatives》.Journal of Chemical and Pharmaceutical Research published the findings.SDS of cas: 622-26-4 The information in the text is summarized as follows:

Synthesis of some novel di-substituted 1-piperidin-4-yl(3,4-dibromphenyl)-1,3-dihydro-2H-benzimidazol-2-one derivatives (6A-6D) were prepared from com. available 1,2-henylenediamine. Compounds (6A-6D) were tested for Gram pos.: Streptococcus pyogenes and Staphylococcus aureus. Gram neg.: Escherichia coli, Pseudomonas arzenous, Proteus vulgaris, Salmonella typhi bacterial cultures. Compounds 6A-6D were found to be highly active against Streptococcus pyogenes and Escherichia coli. In the experiment, the researchers used many compounds, for example, 2-(Piperidin-4-yl)ethanol(cas: 622-26-4SDS of cas: 622-26-4)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.SDS of cas: 622-26-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2014,Sree Ram Babu, J.; Ravi Sankar, T.; Sudhakar Babu, K.; Latha, J. published 《Synthesis, characterization and biological evaluation of some novel disubstituted heterocyclic derivatives》.Journal of Chemical and Pharmaceutical Research published the findings.Computed Properties of C7H15NO The information in the text is summarized as follows:

Synthesis of disubstituted heterocyclic derivatives I [X = 3,4-(Cl)2; R = piperidin-1-yl, 4-hydroxypiperidin-1-yl, piperidin-4-ylmethanol, 2-(piperidin-4-yl)ethan-1-ol] were prepared from com. available 1,2-henylenediamine. The compounds I were tested for Gram pos.: Streptococcus pyogenes and Staphylococcus aureus. Gram neg.: Escherichia coli, Pseudomonas arzenous, Proteus vulgaris, Salmonella typhi bacterial cultures. The compounds I were found to be highly active against Streptococcus pyogenes and Escherichia coli.2-(Piperidin-4-yl)ethanol(cas: 622-26-4Computed Properties of C7H15NO) was used in this study.

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.Computed Properties of C7H15NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2013,Sudhakar Babu, K.; Ravi Sankar, T.; Latha, J.; Ram Babu, B.; SwarnaKumari, M. published 《Synthesis and antibacterial activity of some novel 1-piperidin-4-yl-1,3-dihydro-2H-benzimidazol-2-one analogs》.Journal of Applicable Chemistry (Lumami, India) published the findings.Application In Synthesis of 2-(Piperidin-4-yl)ethanol The information in the text is summarized as follows:

Synthesis of some novel 1-piperidin-4-yl-1,3-dihydro-2H-benzimidazol-2-one derivatives were prepared from com. available 1,2-phenylenediamine. These compounds were tested for their antibacterial activity against gram pos. Streptococcus pyogenes and Staphylococcus aureus and against gram neg. Escherichia coli, Pseudomonas arsenous, Proteus vulgaris, Salmonella typhii bacterial cultures. The title compounds were highly active against Streptococcus pyogenes and Escherichia coli. In addition to this study using 2-(Piperidin-4-yl)ethanol, there are many other studies that have used 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Application In Synthesis of 2-(Piperidin-4-yl)ethanol) was used in this study.

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAKApplication In Synthesis of 2-(Piperidin-4-yl)ethanol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Zuo, Shiyu; Guan, Zeyu; Zhang, Yiming; Yang, Fan; Li, Xiaohu; Li, Dongya published their research in Chemical Engineering Journal (Amsterdam, Netherlands) on December 15 ,2022. The article was titled 《Bidentate binuclear coordination configuration for peroxymonosulfate catalytic regulation through incorporation of CuFeOx to iron-based metal organic frameworks》.Quality Control of Triacetonamine The article contains the following contents:

The scheme of coordination bridge modification provides a new vision for regulating the catalytic pathway, but how to change the surface coordination of peroxymonosulfate (PMS), thereby affecting the catalytic mechanism of PMS, is still an unknown field. In this, we found that MIL-101(Fe) is expected to control the surface catalytic pathway via the bidentate binuclear coordination configuration, thereby realizing the rapid oxidative detoxification of toxic organic pollutants and CO2 conversion. Introducing Cu on the surface of MIL-101(Fe) to change the surface chem. environment (MIL-101(Fe)/CuFeOx) can shift the catalytic pathway, thereby promoting a 14.5-fold improvement in Bisphenol A (BPA) oxidation kinetics (from 0.00697 min-1 to 0.101 min-1). Characterization, experiments, and d. functional theory (DFT) results show that Cu in the vicinity of Fe can tune the electronic structure and properties of Fe-O-Cu, thereby enhancing the electron transfer rate at the active center, facilitating electronic transitions and PMS adsorption. More importantly, shifting the binding configuration of PMS from monodentate mononuclear coordination on a single Fe center to bidentate binuclear coordination on Fe/Cu centers, shorter distance coordination structures and O-O pulling of PMS. The effect promoted PMS cleavage to generate more ROS and changed the catalytic pathway from the radical pathway to the 1O2 and high-valent metal species pathway. The free radical/non-radical pathway co-mediated by 1O2, high-valent metal species, ·OH and SO·-4 can effectively reduce the biotoxicity of toxic organic pollutants, and can utilize alkali environment captures CO2 as a stable carbonate for environmental use. This study provides a strategy for manipulating the catalytic pathway through coordination configuration and a feasible idea for CO2 conversion in wastewater treatment. The experimental part of the paper was very detailed, including the reaction process of Triacetonamine(cas: 826-36-8Quality Control of Triacetonamine)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Quality Control of Triacetonamine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The author of 《Light-Mediated Formal Radical Deoxyfluorination of Tertiary Alcohols through Selective Single-Electron Oxidation with TEDA2+.》 were Aguilar Troyano, Francisco Jose; Ballaschk, Frederic; Jaschinski, Marcel; Oezkaya, Yasemin; Gomez-Suarez, Adrian. And the article was published in Chemistry – A European Journal in 2019. Recommanded Product: 50461-59-1 The author mentioned the following in the article:

The synthesis of tertiary alkyl fluorides through a formal radical deoxyfluorination process was described. This light-mediated, catalyst-free methodol. was fast and broadly applicable allowing for the preparation of C-F bonds from (hetero)benzylic, propargylic and non-activated tertiary alc. derivatives Preliminary mechanistic studies supported that the key step of the reaction is the single-electron oxidation of cesium oxalates-which are readily available from the corresponding tertiary alcs.-with in situ generated TEDA2+ (TEDA: N-(chloromethyl)triethylenediamine), a radical cation derived from Selectfluor. The experimental process involved the reaction of 4-(Pyridin-3-yl)piperidin-4-ol(cas: 50461-59-1Recommanded Product: 50461-59-1)

4-(Pyridin-3-yl)piperidin-4-ol(cas: 50461-59-1) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. Recommanded Product: 50461-59-1

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Ma, Wenjie; Wang, Na; Du, Yunchen; Tong, Tianze; Zhang, Leijiang; Andrew Lin, Kun-Yi; Han, Xijiang published an article on January 15 ,2019. The article was titled 《One-step synthesis of novel Fe3C@nitrogen-doped carbon nanotubes/graphene nanosheets for catalytic degradation of Bisphenol A in the presence of peroxymonosulfate》, and you may find the article in Chemical Engineering Journal (Amsterdam, Netherlands).Electric Literature of C9H17NO The information in the text is summarized as follows:

Developing novel carbocatalysts with available strategies for peroxymonosulfate (PMS) activation has become a popular topic in environmental remediation and protection fields. Herein, using com. K4Fe(CN)6 as the precursor, Fe3C@nitrogen-doped carbon nanotubes/graphene nanosheets (Fe3C@NCNTs/GNS) is synthesized by a direct high-temperature pyrolysis. Characterization results prove that Fe3C@NCNTs/GNS has a relatively high graphitization degree and rich nitrogen doping content, which endow it with excellent catalytic efficiency in PMS activation for powerful removal of Bisphenol A (BPA). Influences of catalyst/oxidant dosages, some inorganic anions, humic acid, and practical sewages are investigated in detail. For mechanism studies, it is found that tert-Bu alc. (TBA)/methanol fails to inhibit BPA degradation, and the primary reactive oxidative species (ROS) are superoxide radical (O·-2) and singlet oxygen (1O2). Discussion on the origin of 1O2 confirms that moderate modification of N atoms in graphitic carbon frameworks plays an essential role in inducing the non-radical mechanism. This work will provide new insights for the preparation of high-performance carbocatalysts in PMS activation and exploring critical roles of N-doping during non-radical processes. After reading the article, we found that the author used Triacetonamine(cas: 826-36-8Electric Literature of C9H17NO)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Electric Literature of C9H17NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Related Products of 826-36-8On October 1, 2021 ,《Highly-efficient and stable MgCo2O4 spinel for bisphenol a removal by activating peroxymonosulfate via radical and non-radical pathways》 was published in Chemical Engineering Journal (Amsterdam, Netherlands). The article was written by Yu, Jiaxin; Qiu, Wei; Xu, Haodan; Lu, Xiaohui; Ma, Jun; Lu, Dongwei. The article contains the following contents:

Nowadays, the limited catalytic efficiency, secondary pollution of metal leaching and stability decrease during reuse bring challenges to practical application of heterogeneous catalysts in sulfate radical-based advanced oxidation processes. Herein, MgCo2O4 spinel was synthesized through hydrothermal method and tested for its catalytic performance of activating PMS by using bisphenol A (BPA) as the target pollutant. MgCo2O4/PMS system can degrade 99.6% BPA efficiently at pH 7.2 within 10 min. The morphol. and physicochem. properties of MgCo2O4 were characterized by SEM (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD). Unlike conventional PMS activation, radical and non-radical pathways were identified through utilizing XPS, ESR (EPR), and radical quenching experiments Tetrahedral Mg2+ might make MgCo2O4 more stable and promote the Co2+/Co3+ redox, which dominated the catalytic ability of MgCo2O4. MgCo2O4 spinel is efficient, stable, low-cost, and simple to synthesize, leading to BPA degradation via both radical and non-radical pathways. This research would extend the mechanism and potential application of spinel catalysis in water treatment. After reading the article, we found that the author used Triacetonamine(cas: 826-36-8Related Products of 826-36-8)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Related Products of 826-36-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

HPLC of Formula: 39546-32-2On September 21, 2020 ,《A General Catalyst Based on Cobalt Core-Shell Nanoparticles for the Hydrogenation of N-Heteroarenes Including Pyridines》 was published in Angewandte Chemie, International Edition. The article was written by Murugesan, Kathiravan; Chandrashekhar, Vishwas G.; Kreyenschulte, Carsten; Beller, Matthias; Jagadeesh, Rajenahally V.. The article contains the following contents:

Herein, we report the synthesis of specific silica-supported Co/Co3O4 core-shell based nanoparticles prepared by template synthesis of cobalt-pyromellitic acid on silica and subsequent pyrolysis. The optimal catalyst material allows for general and selective hydrogenation of pyridines, quinolines, and other heteroarenes including acridine, phenanthroline, naphthyridine, quinoxaline, imidazo[1,2-a]pyridine, and indole under comparably mild reaction conditions. In addition, recycling of these Co nanoparticles and their ability for dehydrogenation catalysis are showcased. In the experiment, the researchers used many compounds, for example, Piperidine-4-carboxamide(cas: 39546-32-2HPLC of Formula: 39546-32-2)

Piperidine-4-carboxamide(cas: 39546-32-2) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.HPLC of Formula: 39546-32-2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2014,Vidadala, Rama Subba Rao; Ojo, Kayode K.; Johnson, Steven M.; Zhang, Zhongsheng; Leonard, Stephen E.; Mitra, Arinjay; Choi, Ryan; Reid, Molly C.; Keyloun, Katelyn R.; Fox, Anna M. W.; Kennedy, Mark; Silver-Brace, Tiffany; Hume, Jen C. C.; Kappe, Stefan; Verlinde, Christophe L. M. J.; Fan, Erkang; Merritt, Ethan A.; Van Voorhis, Wesley C.; Maly, Dustin J. published 《Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes》.European Journal of Medicinal Chemistry published the findings.Synthetic Route of C7H15NO The information in the text is summarized as follows:

Malaria remains a major health concern for a large percentage of the world’s population. While great strides have been made in reducing mortality due to malaria, new strategies and therapies are still needed. Therapies that are capable of blocking the transmission of Plasmodium parasites are particularly attractive, but only primaquine accomplishes this, and toxicity issues hamper its widespread use. In this study, the authors describe a series of pyrazolopyrimidine- and imidazopyrazine-based compounds that are potent inhibitors of PfCDPK4, which is a calcium-activated Plasmodium protein kinase that is essential for exflagellation of male gametocytes. Thus, PfCDPK4 is essential for the sexual development of Plasmodium parasites and their ability to infect mosquitoes. The authors demonstrate that two structural features in the ATP-binding site of PfCDPK4 can be exploited to obtain potent and selective inhibitors of this enzyme. Furthermore, the authors demonstrate that pyrazolopyrimidine-based inhibitors that are potent inhibitors of the in vitro activity of PfCDPK4 are also able to block Plasmodium falciparum exflagellation with no observable toxicity to human cells. This medicinal chem. effort serves as a valuable starting point in the development of safe, transmission-blocking agents for the control of malaria. In the experiment, the researchers used many compounds, for example, 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Synthetic Route of C7H15NO)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAKSynthetic Route of C7H15NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Sun, Ping; Liu, Hui; Zhai, Zhicai; Zhang, Xuesheng; Fang, Yingsen; Tan, Jun; Wu, Jiaqiang published an article on January 15 ,2019. The article was titled 《Degradation of UV filter BP-1 with nitrogen-doped industrial graphene as a metal-free catalyst of peroxymonosulfate activation》, and you may find the article in Chemical Engineering Journal (Amsterdam, Netherlands).SDS of cas: 826-36-8 The information in the text is summarized as follows:

Instead of previously reported graphene oxide (GO), industrial graphene (reduced graphene oxide (IrGO)) was annealed with a nitrogen precursor. The obtained nitrogen-doped graphene (N-IrGO) was then employed as a novel catalyst for peroxymonosulfate (PMS) activation to degrade benzophenone-1 (BP-1) for the first time. The results show that N-IrGO exhibits excellent catalytic performance over conventional GO and its nitrogen-doped sample and was even better than the metal catalysts Co3O4 and Fe3O4. The enhanced catalytic performance might be attributed to graphitic-like nitrogen. Moreover, the effects of various factors were studied, including catalyst load, PMS concentration and reaction temperature Possible degradation pathways of BP-1 in the N-IrGO/PMS system were proposed based on detected intermediates and the frontier electron d. calculation Radical quenching experiments and ESR (EPR) tests indicated that nonradical oxidation (singlet oxygen (1O2)) plays a dominant role in the BP-1 degradation, in contrast to the previously proposed radical process. Finally, mineralization and stability experiments confirmed that N-IrGO may be an alternative catalyst for environmental remediation. This study contributes to designing novel graphene materials with N doping and gives new insight into nonradical oxidation on benzophenone-type UV filters degradation The results came from multiple reactions, including the reaction of Triacetonamine(cas: 826-36-8SDS of cas: 826-36-8)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.SDS of cas: 826-36-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem