Tag: 100-200

《Practical Synthesis of a Stable Precursor for Positron Emission Tomography Imaging Agent 18F-GTP1》 was written by White, Nicholas A.; Clagg, Kyle; Sirois, Lauren E.; Lim, Ngiap-Kie; Nack, William A.; OShea, Paul D.; Zhang, Haiming; Gosselin, Francis. Computed Properties of C7H15NO And the article was included in Organic Process Research & Development in 2020. The article conveys some information:

18F-GTP1 is a deuterated small mol. positron emission tomog. (PET) imaging agent used to visualize tau tangles in Alzheimer’s disease patients. The first-generation synthesis of 18F-GTP1’s non-radiolabeled alkyl tosylate precursor was plagued by low-yielding steps, inefficient chromatog. purifications, and variable product quality. Due to these limitations, a more robust second-generation route was developed and successfully executed on kilogram-scale. A reduction with LiAlD4 incorporated the geminal deuterium atoms, while an efficient amidation reaction accessed the key acrylamide coupling partner. Moreover, the tricyclic imidazo[1,2,a]pyrimidine core was assembled via a novel, convergent, and highly selective phosphoramidate-directed annulation. The improved synthesis eliminated all chromatog. en route to a high-yielding and reproducible acid-promoted tosylation as the final step. In the experiment, the researchers used many compounds, for example, 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Computed Properties of C7H15NO)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.Computed Properties of C7H15NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

《N-Benzyl-4,4-disubstituted piperidines as a potent class of influenza H1N1 virus inhibitors showing a novel mechanism of hemagglutinin fusion peptide interaction》 was published in European Journal of Medicinal Chemistry in 2020. These research results belong to de Castro, Sonia; Ginex, Tiziana; Vanderlinden, Evelien; Laporte, Manon; Stevaert, Annelies; Cumella, Jose; Gago, Federico; Camarasa, Maria Jose; Luque, F. Javier; Naesens, Lieve; Velazquez, Sonsoles. Safety of 1-Methyl-4-piperidone The article mentions the following:

Herein, N-benzyl-4,4,-disubstituted piperidines I (R1 = H, Me, cyclohexyl, Ph, PhCH2, PhCH2CH2; R2 = t-Bu, cyclohexyl, PhCH2, 4-MeC6H4SO2CH2; R3 = H, Me, cyclopropyl, PhCH2, 4-FC6H4CH2, etc.; R4 = Me, MeO2CCH2, PhCH2, etc.; R5 = H, Boc, Cbz) have been designed, synthesized and identified as influenza A virus fusion inhibitors with specific activity against the H1N1 subtype. A diverse library of piperidines I was synthesized using the highly efficient one-step Ugi four-component reaction. Mechanistic studies, including resistance selection with the most active compound I [R1 = R2 = PhCH2; R3 = 4-FC6H4CH2; R4 = MeO2CCH2; R5 = Boc; (II)], demonstrated that it acts as an inhibitor of the low pH-induced HA-mediated membrane fusion process. Computational studies identified an as yet unrecognized fusion inhibitor binding site, which is located at the bottom of the HA2 stem in close proximity to the fusion peptide. A direct π-stacking interaction between the N-benzylpiperidine moiety of the compound II and F9HA2 of the fusion peptide, reinforced with an addnl. π-stacking interaction with Y119HA2, and a salt bridge of the protonated piperidine nitrogen with E120HA2, were identified as important interactions to mediate ligand binding. This site rationalized the observed SAR and provided a structural explanation for the H1N1-specific activity of our inhibitors. Furthermore, the HA1-S326V mutation resulted in resistance to II was close to the proposed new binding pocket. These findings point to the N-benzyl-4,4-disubstituted piperidines as an interesting class of influenza virus inhibitors and represent the first example of fusion peptide binders with great potential for anti-influenza drug development. In the experimental materials used by the author, we found 1-Methyl-4-piperidone(cas: 1445-73-4Safety of 1-Methyl-4-piperidone)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Safety of 1-Methyl-4-piperidone

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2019,European Journal of Medicinal Chemistry included an article by Uprety, Rajendra; Varadi, Andras; Allaoa, Abdullah; Redel-Traub, Gabriel N.; Palmer, Travis C.; Feinberg, Evan N.; Ferris, Alex C.; Pande, Vijay S.; Pasternak, Gavril W.; Majumdar, Susruta. Synthetic Route of C6H11NO. The article was titled 《Synthesis of spiro-2,6-dioxopiperazine and spiro-2,6-dioxopyrazine scaffolds using amino acids in a three-component reaction to generate potential Sigma-1 (σ1) receptor selective ligands》. The information in the text is summarized as follows:

The design and synthesis of novel heterocycles with spiro-2,6-dioxopiperazine and spiro-2,6-pyrazine scaffolds through a three-component reaction using various amino acids, ketones and isocyanides was presented. Screening of selected compounds over fifty CNS receptors including G-protein coupled receptors (GPCRs), ion channels, transporters and enzymes through the NIMH psychoactive drug screening program indicated that a novel spiro-2,6-dioxopyrazine scaffold, e.g., I, displayed high binding affinity at sigma-1 (σ1) receptor in the nanomolar range. In addition, mol. docking of spiro-2,6-dioxopyrazine scaffold, e.g., I at the human σ1 receptor showed that it resides in the same binding site that was occupied by the ligand N-(N-benzylpiperidin-4-yl)-4-iodobenzamide (4-IBP) used to obtain a crystal structure of the human sigma-1 (σ1) receptor. In the experiment, the researchers used 1-Methyl-4-piperidone(cas: 1445-73-4Synthetic Route of C6H11NO)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Synthetic Route of C6H11NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2017,Barberis, Claude; Moorcroft, Neil; Pribish, James; Tserlin, Elina; Gross, Alexandre; Czekaj, Mark; Barrague, Matthieu; Erdman, Paul; Majid, Tahir; Batchelor, Joseph; Levit, Mikhail; Hebert, Andrew; Shen, Liduo; Moreno-Mazza, Sandra; Wang, Anlai published 《Discovery of N-substituted 7-azaindoles as Pan-PIM kinase inhibitors – Lead series identification – Part II》.Bioorganic & Medicinal Chemistry Letters published the findings.Application In Synthesis of 2-(Piperidin-4-yl)ethanol The information in the text is summarized as follows:

N-Substituted azaindoles have been discovered as pan-PIM kinase inhibitors. Initial SAR, early ADME and PK/PD data of a series of compounds is described and led to the identification of promising pan-PIM inhibitors which validated the interest in the 7-azaindole scaffold and led us to pursue the identification of a clin. candidate. After reading the article, we found that the author used 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Application In Synthesis of 2-(Piperidin-4-yl)ethanol)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.Application In Synthesis of 2-(Piperidin-4-yl)ethanol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2014,Belluti, Federica; De Simone, Angela; Tarozzi, Andrea; Bartolini, Manuela; Djemil, Alice; Bisi, Alessandra; Gobbi, Silvia; Montanari, Serena; Cavalli, Andrea; Andrisano, Vincenza; Bottegoni, Giovanni; Rampa, Angela published 《Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer’s disease》.European Journal of Medicinal Chemistry published the findings.Safety of 2-(Piperidin-4-yl)ethanol The information in the text is summarized as follows:

In an effort to develop multipotent agents against β-secretase (BACE-1) and acetylcholinesterase (AChE), able to counteract intracellular ROS formation as well, the structure of the fluorinated benzophenone 3 served as starting point for the synthesis of a small library of 3-fluoro-4-hydroxy- analogs. Among the series, derivatives 5 and 12, carrying chem. different amino functions, showed a balanced micromolar potency against the selected targets. In particular, compound 12, completely devoid of toxic effects, seems to be a promising lead for obtaining effective anti-AD drug candidates. The experimental process involved the reaction of 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Safety of 2-(Piperidin-4-yl)ethanol)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.Safety of 2-(Piperidin-4-yl)ethanol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Yang, Xianglong; Ding, Xing; Wang, Shengyao; Mao, Jin; Cheng, Ling; Li, Peiwu; Chen, Hao published an article in Journal of Colloid and Interface Science. The title of the article was 《Superoxide anion and singlet oxygen dominated faster photocatalytic elimination of nitric oxide over defective bismuth molybdates heterojunctions》.HPLC of Formula: 826-36-8 The author mentioned the following in the article:

Establishing an ideal photocatalytic system with efficient reactive oxygen species (ROS) generation has been regarded as the linchpin for realizing efficient nitric oxide (NO) removal and unveiling the ROS-mediated mechanism. In this work, a novel oxygen-deficient 0D/1D Bi3.64Mo0.36O6.55/Bi2MoO6 heterojunctions (BMO-12-H) were successfully synthesized under the enlightenment of clarified crystal growth mechanism of bismuth molybdates. Because of the synergies between defect-engineering and heterojunction-construction, BMO-12-H demonstrated improved photoelectrochem. properties and O2 adsorption capacity, which in turn facilitated the ROS generation and conversion. The enhancement of •O-2 and 1O2 endowed BMO-12-H with strengthened NO removal efficiency (59%) with a rate constant of 12.6*10-2 min-1. A conceivable NO removal mechanism dominated by •O-2 and 1O2 was proposed and verified based on the theor. calculations and in-situ IR spectroscopy tests, where hazardous NO was oxidized following two different exothermic pathways: the •O-2-induced NO → NO-3 process and the 1O2-induced NO → NO2 → NO-3 process. This work offers a basic guideline for accelerating ROS generation by integrating defect-engineering and heterojunction-construction, and provides new insights into the mechanism of efficient NO removal dominated by •O-2 and 1O2. In the experimental materials used by the author, we found Triacetonamine(cas: 826-36-8HPLC of Formula: 826-36-8)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.HPLC of Formula: 826-36-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Pierson, Pascale David; Fettes, Alec; Freichel, Christian; Gatti-McArthur, Silvia; Hertel, Cornelia; Huwyler, Jorg; Mohr, Peter; Nakagawa, Toshito; Nettekoven, Matthias; Plancher, Jean-Marc; Raab, Susanne; Richter, Hans; Roche, Olivier; Rodriguez Sarmiento, Rosa Maria; Schmitt, Monique; Schuler, Franz; Takahashi, Tadakatsu; Taylor, Sven; Ullmer, Christoph; Wiegand, Ruby published an article in Journal of Medicinal Chemistry. The title of the article was 《5-Hydroxyindole-2-carboxylic Acid Amides: Novel Histamine-3 Receptor Inverse Agonists for the Treatment of Obesity》.HPLC of Formula: 851847-62-6 The author mentioned the following in the article:

Obesity is a major risk factor in the development of conditions such as hypertension, hyperglycemia, dyslipidemia, coronary artery disease, and cancer. Several pieces of evidence across different species, including primates, underscore the implication of the histamine 3 receptor (H3R) in the regulation of food intake and body weight and the potential therapeutic effect of H3R inverse agonists. A pharmacophore model, based on public information and validated by previous investigations, was used to design several potential scaffolds. Out of these scaffolds, the 5-hydroxyindole-2-carboxylic acid amide appeared to be of great potential as a novel series of H3R inverse agonist. Extensive structure-activity relationships revealed the interconnectivity of microsomal clearance and hERG (human ether-a-go-go-related gene) affinity with lipophilicity, artificial membrane permeation, and basicity. This effort led to the identification of compounds reversing the (R)-α-methylhistamine-induced water intake increase in Wistar rats and, further, reducing food intake in diet-induced obese Sprague-Dawley rats. Of these, the biochem., pharmacokinetic, and pharmacodynamic characteristics of (4,4-difluoropiperidin-1-yl)[1-isopropyl-5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl]methanone 36 are detailed. In addition to this study using 1-Cyclopropylpiperidin-4-ol, there are many other studies that have used 1-Cyclopropylpiperidin-4-ol(cas: 851847-62-6HPLC of Formula: 851847-62-6) was used in this study.

1-Cyclopropylpiperidin-4-ol(cas: 851847-62-6) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. HPLC of Formula: 851847-62-6

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2019,Energies (Basel, Switzerland) included an article by Devia-Orjuela, John Steven; Alvarez-Pugliese, Christian E.; Donneys-Victoria, Dayana; Cabrales, Nilson Marriaga; Ho, Luz Edith Barba; Brem, Balazs; Sauciuc, Anca; Gal, Emese; Espin, Douglas; Schichtel, Martin; Lang, Dimitrina; Giardinelli, Sebastiano; Briceno, Maria. Recommanded Product: Triacetonamine. The article was titled 《Evaluation of press mud, vinasse powder and extraction sludge with ethanol in a pyrolysis process》. The information in the text is summarized as follows:

The effluents of the sugar and bio-ethanol industry, mainly vinasse as well as lignocellulosic waste, are produced in high volumes Therefore, their treatment and valorization would reduce the environmental impact and make this industry more productive and competitive. The purpose of this study was to determine the potential use of press mud (lignocellulosic waste), vinasse powder, and vinasse sludge from an extraction process with ethanol, as raw materials for conventional pyrolysis evaluating the physicochem. characteristics that affect this thermochem. process, such as calorific power, d., ash content, volatile material, moisture and nitrogen, sulfur, carbon and hydrogen content, thermogravimetric profile, and quantification of lignin cellulose and hemicellulose. The batch pyrolysis experiments showed that all three wastes could be converted successfully into more valuable products. The powder vinasse led to the formation of the lowest content of bio-char (42.7%), the highest production of volatiles (61.6 weight%), and the lowest ash content (20.5 weight%). Besides, it showed the high heating value of 15.63 MJ/kg. Meanwhile, the extraction sludge presented the highest liquid yield (32%) with the lowest gas formation (18.2 weight%) and the lowest heating value of 8.57 MJ/kg. Thus, the sludge could be a good feedstock for production of bio-oil and bio-char. In the experiment, the researchers used many compounds, for example, Triacetonamine(cas: 826-36-8Recommanded Product: Triacetonamine)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Recommanded Product: Triacetonamine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Guo, Shuai; Liu, Lidong; Guo, Xin; Liu, Tiecheng; Li, Xingcan; Li, Guangyu published an article in Journal of Environmental Chemical Engineering. The title of the article was 《Unveiling the mechanism of NOx precursor formation during sewage sludge pyrolysis: Effects of carbohydrate-protein interactions》.Recommanded Product: Triacetonamine The author mentioned the following in the article:

Municipal sewage sludge poses environmental and health risks, and thus, requires proper disposal using pyrolytic techniques. However, these techniques are hindered by the production of NH3 and HCN (NOx precursors) by the sludge. Hence, a comprehensive understanding of NH3 and HCN formation during sludge pyrolysis is required to minimize its NOx footprint. As sludge N mainly occurs in proteins forms, its transformations can be modeled using amino acids. Here, we aimed to the study the mechanism by which carbohydrates influence the formation of NOx precursors during sludge protein pyrolysis at different temperatures using glutamic acid, tyrosine, and histidine as protein models and cellulose and lignin as carbohydrate models. During pyrolysis, the release of NH3 and HCN was promoted by high temperatures and inhibited by carbohydrates. Despite this inhibitory effect, the results suggested that the release of NH3 should be considered for samples rich in aliphatic amino acids. For glutamic acid and tyrosine, NOx precursor formation was inhibited by N fixation in coke under the action of volatiles produced during carbohydrate pyrolysis. For glutamic acid, adding cellulose and lignin increased the coke-N content by 25.32% and 44.73% at 700°C. For histidine, this effect was ascribed to the ring-opening reactions induced by the free radical products of carbohydrate decomposition and the enhanced transfer of N-containing compounds to tar after ring-opening recombination. Further, heterocyclic-N within tar increased to 69.12% due to lignin-histidine interactions at 700°C. The results of this study can assist in regulating sludge protein pyrolysis intended for minimizing the production of NOx precursors. In the experiment, the researchers used many compounds, for example, Triacetonamine(cas: 826-36-8Recommanded Product: Triacetonamine)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Recommanded Product: Triacetonamine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Related Products of 126832-81-3On October 20, 2017 ,《Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation》 was published in European Journal of Medicinal Chemistry. The article was written by Wang, Zhengyu; Shi, Xiaofan; Zhang, Huan; Yu, Liang; Cheng, Yanhua; Zhang, Hefeng; Zhang, Huibin; Zhou, Jinpei; Chen, Jing; Shen, Xu; Duan, Wenhu. The article contains the following contents:

Glucokinase (GK) activators are being developed for the treatment of type 2 diabetes mellitus (T2DM). However, existing GK activators have risks of hypoglycemia caused by over-activation of GK in islet cells and dyslipidemia caused by over-activation of intrahepatic GK. In the effort to mitigate risks of hypoglycemia and dyslipidemia while maintaining the promising efficacy of GK activator, the authors investigated a series of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific partial GK activators. This led to the identification of compound 72 (tert-Bu(S)-2-(3-(4-(azetidine-1-carbonyl)phenoxy)-5-((1-methoxypropan-2-yl)oxy)benzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate) that showed a good balance between in vitro potency and enzyme kinetic parameters. Compound 72 also protected β-cells from streptozotocin-induced apoptosis. Chronic treatment of compound 72 demonstrated its potent activity in regulation of glucose homeostasis and low risk of dyslipidemia with diabetic db/db mice in oral glucose tolerance test (OGTT). Moreover, acute treatment of compound 72 did not induce hypoglycemia in C57BL/6J mice even at 200 mg/kg via oral administration. The results came from multiple reactions, including the reaction of 1-Pyridin-4-ylpiperidin-4-one(cas: 126832-81-3Related Products of 126832-81-3)

1-Pyridin-4-ylpiperidin-4-one(cas: 126832-81-3) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. Related Products of 126832-81-3

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem