Tag: 100-200

Product Details of 1445-73-4In 2021 ,《High chemical stability anion exchange membrane based on poly(aryl piperidinium): Effect of monomer configuration on membrane properties》 appeared in International Journal of Hydrogen Energy. The author of the article were Long, Chuan; Wang, Zhihua; Zhu, Hong. The article conveys some information:

In recent years, ether-free polyaryl polymers prepared by superacid-catalyzed Friedel-Crafts polymerization have attracted great research interest in the development of anion exchange membranes(AEMs) due to their high alkali resistance and simple synthesis methods. However, the selection of monomers for high-performance polymer backbone and the relationship between polymer structure construction and properties need further investigated. Herein, a series of free-ether poly(aryl piperidinium) (PAP) with different polymer backbone steric construction were synthesized as stable anion exchange membranes. Meta-terphenyl, p-terphenyl and diphenyl-terphenyl copolymer were chosen as monomers to regulate the spatial arrangement of the polymer backbone, which tethered with stable piperidinium cation to improve the chem. stability. In addition, a multi-cation crosslinking strategy has been applied to improve ion conductivity and mech. stability of AEMs, and further compared with the performance of uncrosslinked AEMs. The properties of the resulting AEMs were investigated and correlated with their polymer structure. In particular, m-terphenyl based AEMs exhibited better dimensional stability and the highest hydroxide conductivity of 144.2 mS/cm at 80°C than other membranes, which can be attributed to their advantages of polymer backbone arrangement. Furthermore, the hydroxide conductivity of the prepared AEMs remains 80%-90% after treated by 2 M NaOH for 1600 h, exhibiting excellent alk. stability. The single cell test of m-PTP-20Q4 exhibits a maximum power d. of 239 mW/cm2 at 80°C. Hence, the results may guide the selection of polymer monomers to improve performance and alk. durability for anion exchange membranes.1-Methyl-4-piperidone(cas: 1445-73-4Product Details of 1445-73-4) was used in this study.

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Product Details of 1445-73-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Tang, Weiqin; Mu, Tong; Che, Xuefu; Dong, Jianhao; Yang, Jingshuai published their research in ACS Sustainable Chemistry & Engineering in 2021. The article was titled 《Highly Selective Anion Exchange Membrane Based on Quaternized Poly(triphenyl piperidine) for the Vanadium Redox Flow Battery》.Recommanded Product: 1445-73-4 The article contains the following contents:

Vanadium redox flow batteries (VRFBs) have attracted great attention recently owing to the increasing supply of intermittent renewable energies. However, VRFBs usually suffer from serious vanadium ion crossover and high cost when perfluorinated membranes are employed as the separator. In this study, a highly selective anion exchange membrane (AEM) is synthesized from the aryl ether-free poly(terphenyl piperidine) (PTP). Using 3-chloro-2-hydroxypropyltrimethyl ammonium chloride (CHPTMA-Cl) as the quaternization reagent, not only are the piperidinium cations formed in the PTP main chain, but also the side-chain quaternary ammonium cation and hydroxyl group are introduced into the PTP backbone. Compared with pure PTP-TFA and Me quaternized PTP (PTP-Me) membranes, the obtained hydroxypropyltrimethyl ammonium grafted poly(terphenyl piperidinium) (PTP-CHPTMA) membrane exhibits high H+ permeability (1.82 x 10-5 cm2 min-1) and low area resistance (0.35 Ω cm2) mainly due to the presence of the hydrophilic hydroxyl group. Owing to the electrostatic repulsion effect of main-chain piperidinium and side-chain quaternary ammonium cations to vanadium ions, the PTP-CHPTMA membrane achieves a low vanadium ion permeability (1.21 x 10-8 cm2 min-1). Consequently, the PTP-CHPTMA membrane reaches 2 orders of magnitude higher ion selectivity than Nafion 115. The assembled single VRFB with PTP-CHPTMA possesses high Coulombic efficiencies of close to 100% at 60-160 mA cm-2 and higher energy efficiencies than the cell with Nafion 115. The self-discharge duration of the cell with PTP-CHPTMA (381 h) is nearly 4.5 times longer than that of Nafion 115 (86 h). Meanwhile, the VRFB based on PTP-CHPTMA displays excellent cycle stability and discharge capacity retention over 580 charge-discharge cycles at 100 mA cm-2. The results came from multiple reactions, including the reaction of 1-Methyl-4-piperidone(cas: 1445-73-4Recommanded Product: 1445-73-4)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Recommanded Product: 1445-73-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2018,European Journal of Medicinal Chemistry included an article by Bai, Zhongjie; Zhang, Jinlong; Zhang, Qiuping; Zhang, Taofeng; Li, Jili; Zhao, Quanyi; Wang, Zhen; He, Dian; Cheng, Jie; Zhang, Jingke; Liu, Bin. Reference of 2-(Piperidin-4-yl)ethanol. The article was titled 《Synthesis, toxicities and bio-activities of manganese complexes with CO and H2S dual donors》. The information in the text is summarized as follows:

A series of H2S-CO dual-donors [Mn(CO)4CS2NR1R2] was synthesized, and evaluated from toxicity and bioactivity. The CO-H2S measuring test showed all the complexes not only released CO, but released H2S. The resulting data of cytotoxicity showed all the complexes had activities against the cell proliferation; among them, complexes 1, 2 and 7 displayed higher activities than the others, and their potencies were close to cis-platinum (DDP); whereas the precursors A1-A22 had almost no activities against all five tumor cell lines and W138 cell line proliferation. It is worth noting that complex 1 displayed the highest activity to MCF-7, complex 2 displayed the highest activity to HePG2, and complex 7 showed selectivity inhibition to both A549 and HeLa. The developmental toxicities of the complex were assessed using zebrafish embryos. The results showed complexes 1 and 2 had effect on the mortality and hatching rate of zebrafish embryos in dose-dependent manner. They caused zebrafish malformations when they were over 10 μM. Meanwhile, they displayed dose-dependent toxicities to larval zebrafish. In the test of bio-activities, complexes 1 and 2 had strong anti-inflammatory activities; they not only down-regulated the expression levels of iNOS and TNF-α, up-regulated the expression of HO-1 and IL-10, but also up-regulated COX-2 levels. In contrast, the precursor compound (A1 or A2) displayed lower anti-inflammatory activity than the corresponding complex, which suggests both the CO and H2S from the complex took synergistic effects in the process of anti-inflammation. In addition, the complex showed antihypertensive effect and myocardial protection. This effect also possibly resulted from this synergistic effect. All these suggest the complexes have potential to be candidate medicines. After reading the article, we found that the author used 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Reference of 2-(Piperidin-4-yl)ethanol)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.Reference of 2-(Piperidin-4-yl)ethanol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Yang, Hao; Murigi, Francis N.; Wang, Zhijian; Li, Junfeng; Jin, Hongjun; Tu, Zhude published an article on February 15 ,2015. The article was titled 《Synthesis and in vitro characterization of cinnoline and benzimidazole analogues as phosphodiesterase 10A inhibitors》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Name: 4-(Pyridin-3-yl)piperidin-4-ol The information in the text is summarized as follows:

Fifteen cinnoline analogs and six benzimidazole phosphodiesterase 10A (PDE10A) inhibitors were synthesized as potential PET radiopharmaceuticals and their in vitro activity as PDE10A inhibitors was determined Nine out of twenty-one compounds were potent inhibitors of PDE10A with IC50 values ranging from 1.5 to 18.6 nM. Notably, the IC50 values of compounds I [R = H, F] and II were 1.52 ± 0.18, 2.86 ± 0.10, and 3.73 ± 0.60 nM, resp.; these three compounds also showed high in vitro selectivity (>1000-fold) for PDE10A over PDE 3A/3B, PDE4A/4B. The high potency and selectivity of these three compounds suggests that they could be radiolabeled with PET radionuclides for further evaluation of their in vivo pharmacol. behavior and ability to quantify PDE10A in the brain. After reading the article, we found that the author used 4-(Pyridin-3-yl)piperidin-4-ol(cas: 50461-59-1Name: 4-(Pyridin-3-yl)piperidin-4-ol)

4-(Pyridin-3-yl)piperidin-4-ol(cas: 50461-59-1) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. Name: 4-(Pyridin-3-yl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Kuroda, Shoichi; Kobashi, Yohei; Kawamura, Madoka; Kawabe, Kenichi; Shiozawa, Fumiyasu; Hamada, Makoto; Shimizu, Yuki; Okumura-Kitajima, Lisa; Koretsune, Hiroko; Kimura, Kayo; Yamamoto, Koji; Kakinuma, Hiroyuki published an article in Chemical & Pharmaceutical Bulletin. The title of the article was 《Synthesis and structure-activity relationship of C-phenyl D-glucitol (TP0454614) derivatives as selective sodium-dependent glucose cotransporter 1 (SGLT1) inhibitors》.Reference of Piperidine-4-carboxamide The author mentioned the following in the article:

Sodium-glucose cotransporter 1 (SGLT1) is the primary transporter for glucose absorption from the gastrointestinal tract. While C-Ph d-glucitol derivative SGL5213 has been reported to be a potent intestinal SGLT1 inhibitor for use in the treatment of type 2 diabetes, no SGLT1 selectivity was found in vitro (IC50 29 nM for hSGLT1 and 20 nM for hSGLT2). In this study we found a new method of synthesizing key intermediates 12 by a one-pot three-component condensation reaction and discovered C-Ph d-glucitol 41j (TP0454614), which has >40-fold SGLT1 selectivity in vitro (IC50 26 nM for hSGLT1 and 1101 nM for hSGLT2). The results of our study have provided new insights into the structure-activity relationships (SARs) of the SGLT1 selectivity of C-glucitol derivatives The results came from multiple reactions, including the reaction of Piperidine-4-carboxamide(cas: 39546-32-2Reference of Piperidine-4-carboxamide)

Piperidine-4-carboxamide(cas: 39546-32-2) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Reference of Piperidine-4-carboxamide

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

HPLC of Formula: 826-36-8On November 15, 2022 ,《Ultrasonic treatment enhances the formation of oxygen vacancies and trivalent manganese on α-MnO2 surfaces: Mechanism and application》 appeared in Journal of Colloid and Interface Science. The author of the article were Yi, Hailing; Wang, Yanhao; Diao, Lingling; Xin, Yanjun; Chai, Chao; Cui, Dejie; Ma, Dong. The article conveys some information:

Catalytic activity is the main obstacle limiting the application of peroxymonosulfate (PMS) activation on transition metal oxide catalysts in organic pollutant removal. Herein, ultrasonic treatment was applied to α-MnO2 to fabricate a new u-α-MnO2 catalyst for PMS activation. Di-Me phthalate (DMP, 10 mg/L) was almost completely degraded within 90 min, and the pseudofirst-order rate constant for DMP degradation in the u-α-MnO2/PMS system was ∼7 times that in the initial α-MnO2/PMS system. The ultrasonic treatment altered the crystalline and pore structures of α-MnO2 and produced defects on the u-α-MnO2 catalyst. According to the XPS, TG, and EPR results, higher contents of trivalent Mn and oxygen vacancies (OVs) were produced on the catalyst surfaces. The OVs induced the decomposition of PMS to produce 1O2, which was identified as the main reactive oxygen species (ROS) responsible for DMP degradation The u-α-MnO2 catalyst presented great reusability, especially by ultrasonic regeneration of OVs toward the used catalyst. This study provides new insights into regulating OVs generation and strengthening catalyst activity in the PMS activation process for its application in water purification In the part of experimental materials, we found many familiar compounds, such as Triacetonamine(cas: 826-36-8HPLC of Formula: 826-36-8)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.HPLC of Formula: 826-36-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The author of 《Continuous-Flow Synthesis of Phenothiazine Antipsychotics: A Feasibility Study》 were Movsisyan, Marine; De Coen, Laurens M.; Heugebaert, Thomas S. A.; Verlee, Arno; Roman, Bart I.; Stevens, Christian V.. And the article was published in European Journal of Organic Chemistry in 2019. Safety of 2-(Piperidin-4-yl)ethanol The author mentioned the following in the article:

The continuous flow synthesis of a model phenothiazine I antipsychotic was reported, using 3-chloropropionyl chloride as a central building block. The basic phenothiazine-derived scaffold was (atom)-efficiently and mildly synthesized with the aim to present continuous flow technol. as a contributor to fast and efficient synthesis of challenging APIs, which were experiencing supply disruptions and global shortages. The experimental process involved the reaction of 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Safety of 2-(Piperidin-4-yl)ethanol)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAKSafety of 2-(Piperidin-4-yl)ethanol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2016,Park, Jung Sang; Im, Weonbin; Choi, Sunghak; Park, Sook Jin; Jung, Jun Min; Baek, Ki Seon; Son, Han Pyo; Sharma, Satyasheel; Kim, In Su; Jung, Young Hoon published 《Discovery and SAR of N-(1-((substituted piperidin-4-yl)methyl)-3-methoxypiperidin-4-yl)-2-methoxybenzamide derivatives: 5-Hydroxytryptamine receptor 4 agonist as a potent prokinetic agent》.European Journal of Medicinal Chemistry published the findings.Formula: C7H15NO The information in the text is summarized as follows:

A series of novel benzamide derivatives altering the 4-fluorophenylalkyl moiety in cisapride, was synthesized as 5-HT4 receptor agonists; and SAR of these analogs was examined on in vitro and in vivo prokinetic activities. These compounds were synthesized for high 5-HT4 receptor binding affinities and low hERG affinities. Several types of analogs were obtained and screened for 5-HT4 binding, hERG blocking, agonism and gastric emptying assessment. Among the analogs, compound I showed promising results compared with the other analogs with respect to gastric emptying rates in rats and can be a clin. candidate for the development of a potent prokinetic agent to treat GI disorders. In the experiment, the researchers used many compounds, for example, 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Formula: C7H15NO)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAKFormula: C7H15NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2014,Gao, Mingzhang; Wang, Min; Zheng, Qi-Huang published 《Concise and high-yield synthesis of T808 and T808P for radiosynthesis of [18F]-T808, a PET tau tracer for Alzheimer’s disease》.Bioorganic & Medicinal Chemistry Letters published the findings.COA of Formula: C7H15NO The information in the text is summarized as follows:

The authentic standard T808 and its corresponding mesylate precursor T808P were synthesized in six steps using Et vinyl ether and trichloroacetyl chloride as starting materials. The overall chem. yields of T808 and T808P were 35% and 52%, resp. [18F]-T808 was synthesized from T808P by the nucleophilic substitution with K[18F]F/Kryptofix 2.2.2 and isolated by HPLC combined with solid-phase extraction (SPE) purification in 35-45% radiochem. yield with 37-370 GBq/μmol specific activity at end of bombardment (EOB). In addition to this study using 2-(Piperidin-4-yl)ethanol, there are many other studies that have used 2-(Piperidin-4-yl)ethanol(cas: 622-26-4COA of Formula: C7H15NO) was used in this study.

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.COA of Formula: C7H15NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Zuo, Zeping; Chen, Miaomiao; Shao, Xiaoni; Qian, Xinying; Liu, Xiaocong; Zhou, Xia; Xiang, Jiawei; Deng, Pengchi; Li, Yan; Jie, Hui; Liu, Chunqi; Cen, Xiaobo; Xie, Yongmei; Zhao, Yinglan published an article on February 15 ,2020. The article was titled 《Design and biological evaluation of tetrahydropyridine derivatives as novel human GPR119 agonists》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Electric Literature of C6H12N2O The information in the text is summarized as follows:

A series of novel tetrahydropyridine derivatives were prepared and evaluated using cell-based measurements. Systematic optimization of general structure G-1 led to the identification of compound 4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-(1-(5-ethylpyrimidin-2-yl)1,2,3,6-tetrahydropyridin-4-yl)thiazole (EC50 = 4.9 nM) and 2-(1-(5-ethylpyrimidin-2-yl)-1,2,3,6-tetrahydropyridin-4-yl)-4-((2-fluoro-4(1H-tetrazol-1-yl)phenoxy)methyl)thiazole (EC50 = 8.8 nM) with high GPR119 agonism activity and moderate clog P. Through single and long-term pharmacodynamic experiments, compound 4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-(1-(5-ethylpyrimidin-2-yl)1,2,3,6-tetrahydropyridin-4-yl)thiazole showed a hypoglycemic effect and may have an effect on improving basal metabolic rate in DIO mice. Both in vitro and in vivo tests indicated that compound 4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-(1-(5-ethylpyrimidin-2-yl)1,2,3,6-tetrahydropyridin-4-yl)thiazole was a potential potent GPR119 agonist in allusion to T2DM treatment. The experimental part of the paper was very detailed, including the reaction process of Piperidine-4-carboxamide(cas: 39546-32-2Electric Literature of C6H12N2O)

Piperidine-4-carboxamide(cas: 39546-32-2) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Electric Literature of C6H12N2O

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem