Tag: 100-200

In 2015,Kumar, Sunil; Pathania, Anoop S.; Satti, Naresh K.; Dutt, Parbhu; Sharma, Neha; Mallik, Fayaz A.; Ali, Asif published 《Synthetic modification of hydroxychavicol by Mannich reaction and alkyne-azide cycloaddition derivatives depicting cytotoxic potential》.European Journal of Medicinal Chemistry published the findings.HPLC of Formula: 622-26-4 The information in the text is summarized as follows:

Here we report the design, synthesis and lead optimization of hydroxychavicol (I) a high yielding metabolite ubiquitously present in the Piper betel leaves with the significant cytotoxic activity. This is the first report to describe the synthetic strategies of two distinct series of hydroxychavicol by Mannich reaction and alkyne-azide cycloaddition Furthermore, all the synthesized derivatives along with parent compound were evaluated for their in-vitro cytotoxic and antiproliferative potential in several distinct cancers cell lines. Among all, the Mannich reaction derived mols., e.g., II, displayed more potent cytotoxic activities with IC50 value in a range from 3 to 9 μM, which were 7-10 fold more potent than I against five human cancer cell lines viz. HL-60, Mia PaCa-2, MCF-7, HEP G2 and SK-N-SH. Our results describe an efficient synthetic approach used to evaluate the structure activity relationship of I and its derivative in search of potential new anticancer agents. After reading the article, we found that the author used 2-(Piperidin-4-yl)ethanol(cas: 622-26-4HPLC of Formula: 622-26-4)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.HPLC of Formula: 622-26-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Tang, Kai; Zhao, Min; Wu, Ya-Hong; Wu, Qiong; Wang, Shu; Dong, Yu; Yu, Bin; Song, Yihui; Liu, Hong-Min published an article on February 15 ,2022. The article was titled 《Structure-based design, synthesis and biological evaluation of aminopyrazines as highly potent, selective, and cellularly active allosteric SHP2 inhibitors》, and you may find the article in European Journal of Medicinal Chemistry.Computed Properties of C6H12N2O The information in the text is summarized as follows:

Src homol.-2-containing protein tyrosine phosphatase 2 (SHP2) encoded by the proto-oncogene PTPN11 is the first identified non-receptor protein tyrosine phosphatase. SHP2 dysregulation contributes to the pathogenesis of different cancers, making SHP2 a promising therapeutic target for cancer therapy. In this article, authors report the structure-guided design based on the well-characterized SHP2 inhibitor SHP099, extensive structure-activity relationship studies (SARs) of aminopyrazines, biochem. characterization and cellular potency. These medicinal chem. efforts lead to the discovery of the lead compound TK-453 I, which potently inhibits SHP2 (SHP2WT IC50 = 0.023μM, ΔTm = 7.01°C) in a reversible and noncompetitive manner. Compound I exhibits high selectivity over SHP2PTP, SHP1 and PTP1B, and may bind at the “”tunnel”” allosteric site of SHP2 as SHP099. As the key pharmacophore, the aminopyrazine scaffold not only reorganizes the cationic-π stacking interaction with R111 via the novel hydrogen bond interaction between the S atom of thioether linker and T219, but also mediates a hydrogen bond with E250. In vitro studies indicate that I inhibits proliferation of HeLa, KYSE-70 and THP-1 cells moderately and induces apoptosis of Hela cells. Further mechanistic studies suggest that I can decrease the phosphorylation levels of AKT and Erk1/2 in HeLa and KYSE-70 cells.Piperidine-4-carboxamide(cas: 39546-32-2Computed Properties of C6H12N2O) was used in this study.

Piperidine-4-carboxamide(cas: 39546-32-2) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Computed Properties of C6H12N2O

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Park, Seonghun; Lee, Jieun; Kim, Bongkyum; Yuan, Daqiang; Chen, Ying-Pin; Park, Jinhee published an article in Microporous and Mesoporous Materials. The title of the article was 《Unprecedented porosity transformation of hierarchically porous TiO2 derived from Ti-Oxo clusters》.Safety of Triacetonamine The author mentioned the following in the article:

Although attaining a high porosity in TiO2 is critical to enhancing its photocatalytic and photoelec. activities, its synthesis has been challenging owing to the high reactivity of conventional Ti precursors and the laborious template removal process. Thus, we herein report a versatile method for preparing hierarchically porous organic-functionalized TiO2 (HiPOTs) using Ti-oxo clusters consisting of a rigid reactive ligand, para-aminobenzoate (p-ABA). The presence of p-ABA as a structure-directing template is crucial to obtain microporous structures with sufficiently high yields. The HiPOTs gradually transform from hierarchically micro/mesoporous structures into mesoporous structures during a sol-gel process. The Brunauer-Emmett-Teller surface areas of the HiPOTs range from 242 to 739 m2/g, which are among the highest reported for porous TiO2 materials. The presence of p-ABA on the HiPOT surface decreases the band gap of TiO2 to 2.7 eV, and prolonging the sol-gel process releases greater quantities of p-ABA, thereby increasing the band gap and the crystallinity of the anatase phase. Interestingly, unlike conventional TiO2, which experiences rapid charge recombination, the Ti3+ oxidation states of HiPOTs are successfully isolated during UV irradiation and can be applied as a proof of concept to generate reactive oxygen species such as 1O2 and •O-2. The experimental process involved the reaction of Triacetonamine(cas: 826-36-8Safety of Triacetonamine)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Safety of Triacetonamine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Recommanded Product: 622-26-4In 2013 ,《Investigation of temperature sensitivity behaviors of water soluble polyacrylamides》 was published in Journal of Applied Polymer Science. The article was written by Uguzdogan, Erdal; Denkbas, Emir Baki; Kabasakal, Osman Sermet. The article contains the following contents:

Temperature sensitive polymers with a lower critical solution temperature (LCST) are used in a variety of industries such as the pharmaceutical, cosmetic, food, and paint. These polymers are generally of the poly(N-alkylacrylamide) type, of which poly(N-isopropylacrylamide) (PNIPA) is the most commonly used. More novel poly(N-alkylacrylamide)s have also been the subject of much attention recently. In this study, N-alkylacrylamides containing different alkyl groups were synthesized by nucleophilic substitution reactions of various amines with acryloyl chloride. They were polymerized using the solution polymerization method, and the temperature sensitivities of the polymers were investigated. For this purpose, three monomers, N,N-diethylacrylamide, N-cyclopropylacrylamide, and 4-piperidineethanolacrylamide, were synthesized using diethylamine, cyclopropylamine, and 4-piperidineethanol, as the amines, resp. The obtained polymers, poly(N,N-diethylacrylamide) (PDEA), poly(N-cyclopropylacrylamide) (PCPA), and poly(4-piperidineethanolacrylamide) (PPEA), were found to be thermo-responsive, particularly PPEA is a potential novel material that can be utilized as an alternative to the common temperature sensitive polymers. The effects of several conditions on the LCST and the critical flocculation temperature (CFT) of the polymers were also investigated. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2012.2-(Piperidin-4-yl)ethanol(cas: 622-26-4Recommanded Product: 622-26-4) was used in this study.

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAKRecommanded Product: 622-26-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Synthetic Route of C6H11NOIn 2022 ,《Supported Anionic Gold Nanoparticle Catalysts Modified Using Highly Negatively Charged Multivacant Polyoxometalates》 was published in Angewandte Chemie, International Edition. The article was written by Xia, Kang; Yatabe, Takafumi; Yonesato, Kentaro; Yabe, Tomohiro; Kikkawa, Soichi; Yamazoe, Seiji; Nakata, Ayako; Yamaguchi, Kazuya; Suzuki, Kosuke. The article contains the following contents:

Although supported anionic gold nanoparticle catalysts have been theor. investigated for their efficacy in activating O2 in aerobic oxidation reactions, limited studies have been reported due to the difficulty of designing these catalysts. Herein, we developed a feasible method for preparing supported anionic gold nanoparticle catalysts using multivacant lacunary polyoxometalates with high neg. charges. We confirmed the strong and robust electronic interaction between gold nanoparticles and multivacant lacunary polyoxometalates, and the electronic states of the supported gold nanoparticle catalysts can be sequentially modulated. Particularly, the catalyst prepared using [SiW9O34]10- acted as an efficient reusable heterogeneous catalyst, showing superior catalytic performance for the oxidative dehydrogenation of piperidone derivatives to the corresponding enaminones and remarkably higher stability than supported gold nanoparticle catalysts without this modification. In the part of experimental materials, we found many familiar compounds, such as 1-Methyl-4-piperidone(cas: 1445-73-4Synthetic Route of C6H11NO)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Synthetic Route of C6H11NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Ishihara, Tsukasa; Seki, Norio; Hirayama, Fukushi; Orita, Masaya; Koshio, Hiroyuki; Taniuchi, Yuta; Sakai-Moritani, Yumiko; Iwatsuki, Yoshiyuki; Kaku, Seiji; Kawasaki, Tomihisa; Matsumoto, Yuzo; Tsukamoto, Shin-ichi published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Prodrug-based design, synthesis, and biological evaluation of N-benzenesulfonylpiperidine derivatives as novel, orally active factor Xa inhibitors》.HPLC of Formula: 126832-81-3 The author mentioned the following in the article:

We describe here our investigation of a new series of orally active fXa inhibitors based on a prodrug strategy. Solid-phase parallel synthesis identified a unique series of fXa inhibitors with a substituted benzenesulfonyl group as a novel S4 binding element. This series resulted in compound 39 (I), which exhibited potent inhibitory activity against fXa (IC50 = 13 nM) and excellent selectivity over thrombin (>7000-fold). The masking of its highly hydrophilic groups led to the creation of related prodrug 28, which demonstrated an anticoagulant effect after oral dosing. In addition to this study using 1-Pyridin-4-ylpiperidin-4-one, there are many other studies that have used 1-Pyridin-4-ylpiperidin-4-one(cas: 126832-81-3HPLC of Formula: 126832-81-3) was used in this study.

1-Pyridin-4-ylpiperidin-4-one(cas: 126832-81-3) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. HPLC of Formula: 126832-81-3

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Cheng, Yarui; Zhang, Tianyuan; Cao, Yangrong; Wang, Li; Chen, Wenli published an article in Applied Microbiology and Biotechnology. The title of the article was 《New insights into the function of the proteins IsiC and IsiD from Synechocystis sp. PCC 6803 under iron limitation》.COA of Formula: C6H12N2O The author mentioned the following in the article:

Iron is a common cofactor in biol. processes such as respiration, photosynthesis, and nitrogen fixation. The genes isiC and isiD encode unknown proteins, and the growth of ΔisiC and ΔisiD mutants is inhibited under iron-deficient conditions. To study the regulatory mechanisms of IsiC and IsiD during iron starvation, we carried out transcriptome and metabolome sequencing. The Kyoto Encyclopedia of Genes and Genomes (KEGG) anal. showed that the photosynthesis, nitrogen metabolism, and ABC transporter pathways play a vital role in regulating iron deficiency. Upon iron repletion, IsiC and IsiD also have a regulatory effect on these pathways. Addnl., KEGG anal. of the differential metabolites of wild type (WT) and mutants showed that they were all enriched in starch and sucrose metabolism after iron limitation. Weighted gene co-expression network anal. (WGCNA) constructed a co-expression network of differentially expressed genes with phenotypes and metabolites, and finally identified five modules. The turquoise module was pos. correlated with iron deficiency. In contrast, the WT and blue module exhibited a neg. correlation, and the mutants ΔisiC and ΔisiD were pos. correlated with the gray and brown modules, resp. WGCNA also analyzed the relationship between metabolites and phenotypes, and the green module was related to iron starvation. The co-expression network determined the hub genes and metabolites of each module. This study lays a foundation for a better understanding of cyanobacteria in response to iron deficiency. In addition to this study using Piperidine-4-carboxamide, there are many other studies that have used Piperidine-4-carboxamide(cas: 39546-32-2COA of Formula: C6H12N2O) was used in this study.

Piperidine-4-carboxamide(cas: 39546-32-2) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).COA of Formula: C6H12N2O

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Bai, Rui; Xiao, Yong; Yan, Weifu; Wang, Siqi; Ding, Rui; Yang, Fan; Li, Junpeng; Lu, Xiaoquan; Zhao, Feng published an article in Environmental Science and Pollution Research. The title of the article was 《Rapid and efficient removal of naproxen from water by CuFe2O4 with peroxymonosulfate》.Category: piperidines The author mentioned the following in the article:

Abstract: Naproxen, a widely used nonsteroidal anti-inflammatory drug, has been detected in many environmental matrixes and is regarded as an emerging pollutant. Sulfate radical (SO4·-) -based advanced oxidation processes have attracted wide attention due to their high efficiency and applicability in the removal of emerging contaminants. In this study, CuFe2O4 was used as an efficient catalyst to activate peroxymonosulfate to oxidize naproxen. The results suggested that 92.3% of naproxen was degraded and 50.3% total organic carbon was removed in 60 min in the presence of 0.3 g·L-1 CuFe2O4 and 2 mM peroxymonosulfate. This degradation system showed strong adaptability in a wide pH range from 4.0 to 10.0. Free radical scavenger experiments and ESR anal. indicated that 1O2, ·OH, and SO4·- are the main active species. Finally, the potential degradation pathways of naproxen were proposed by detecting and analyzing the degradation products with ultra-high-performance liquid chromatog. combined with mass spectrometry. The results of this study suggest that the CuFe2O4-activated peroxymonosulfate system is a promising technol. for the removal of naproxen from natural water. The results came from multiple reactions, including the reaction of Triacetonamine(cas: 826-36-8Category: piperidines)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

《Trichloroacetic acid fueled practical amine purifications》 was published in Beilstein Journal of Organic Chemistry in 2022. These research results belong to Thomas, Aleena; Gasch, Baptiste; Olivieri, Enzo; Quintard, Adrien. Application of 826-36-8 The article mentions the following:

On out of equilibrium mol. machinery, using trichloroacetic acid (TCA), disclosed a purification technique considerably decreasing the number of operations and the waste generation required for such purifications. At first, TCA triggered the precipitation of the amines through their protonated salt formation, enabling the separation with the impurities. From these amine salts, simple decarboxylation of TCA liberated volatile CO2 and chloroform afforded directly the pure amines. Through this approach, a broad range of diversely substituted amines were isolated with success. The experimental part of the paper was very detailed, including the reaction process of Triacetonamine(cas: 826-36-8Application of 826-36-8)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Application of 826-36-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

《Synthesis and Anticancer Activity of New Substituted Piperidinones Linked to Pyrimidine, Thiazole, and Triazole Glycoside Derivatives》 was written by Yousif, M. N. M.; Nassar, I. F.; Yousif, N. M.; Awad, H. M.; El-Sayed, W. A.. Application In Synthesis of Triacetonamine And the article was included in Russian Journal of General Chemistry on August 31 ,2019. The article conveys some information:

New piperidinone incorporating pyrimidine, triazine, diazipine, oxatriazine, and thiazole derivatives have been synthesized starting with tetramethylpipridin-4-one. Structures of the newly synthesized compounds are characterized on the basis of spectroscopic and anal. data. The anticancer activity of the prepared compounds has been studied in vitro against HCT-116 and MCF-7 human cancer cells using the MTT assay. A number of compounds demonstrates potent activity towards both cell lines with IC50 values comparable with doxorubicin. In the experiment, the researchers used Triacetonamine(cas: 826-36-8Application In Synthesis of Triacetonamine)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Application In Synthesis of Triacetonamine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem