Tag: 100-200

Swain, C. J.; Baker, R.; Kneen, C.; Moseley, J.; Saunders, J.; Seward, E. M.; Stevenson, G.; Beer, M.; Stanton, J.; Watling, K. published an article on January 31 ,1991. The article was titled 《Novel 5-HT3 antagonists. Indole oxadiazoles》, and you may find the article in Journal of Medicinal Chemistry.Safety of Methyl 1-methylpiperidine-3-carboxylate The information in the text is summarized as follows:

The synthesis and biochem. evaluation of a series of oxadiazole and indolyloxadiazole 5-HT3 (hydroxytryptamine) antagonists are described. The key pharmacophoric elements have been defined as a basic nitrogen, a linking group capable of H-bonding interactions, and an aromatic moiety. The steric limitations of the aromatic binding site have been determined by substitution about the indole ring. Variation of the heterocyclic linking group has shown that while 2 H-bonding interactions are possible, only 1 is essential for high affinity. The environment of the basic nitrogen has been investigated and shown to be optimal when constrained within an azabicyclic system. These results have been incorporated into a proposed binding model for the 5-HT3 antagonist binding site, in which the optimum distance between the aromatic binding site and the basic amine is 8.4-8.9 Å and the steric limitations are defined by van der Waals difference mapping. The experimental process involved the reaction of Methyl 1-methylpiperidine-3-carboxylate(cas: 1690-72-8Safety of Methyl 1-methylpiperidine-3-carboxylate)

Methyl 1-methylpiperidine-3-carboxylate(cas: 1690-72-8) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Safety of Methyl 1-methylpiperidine-3-carboxylate

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Madsen, Ulf; Brehm, Lotte; Schaumburg, Kjeld; Joergensen, Flemming S.; Krogsgaard-Larsen, Povl published an article on January 31 ,1990. The article was titled 《Relationship between structure, conformational flexibility, and biological activity of agonists and antagonists at the N-methyl-D-aspartic acid subtype of excitatory amino acid receptors》, and you may find the article in Journal of Medicinal Chemistry.Application In Synthesis of Cis-piperidine-2,6-dicarboxylic acid The information in the text is summarized as follows:

The relationship between conformational flexibility and agonist or antagonist actions at the N-methyl-D-aspartic acid (NMDA) subtype of central L-glutamic acid (GLU) receptors of a series of racemic piperidinedicarboxylic acids (PDAs) was studied. The conformational analyses were based on 1H NMR spectroscopy and supported by computer simulations and mol. mechanics calculations While the trans-forms of 2,3-PDA and 2,4-PDA and cis-2,5-PDA show NMDA receptor agonist activities, cis-2,3-PDA and cis-2,4-PDA are NMDA antagonists. The compounds trans-2,5-PDA and cis-2,6-PDA did not interact with NMDA receptors. Each of the 3 cyclic acidic amino acids showing NMDA agonist activities existed as an equilibrium mixture of 2 conformers in aqueous solution In contrast, the NMDA antagonists cis-2,3-PDA and cis-2,4-PDA as well as the inactive compounds trans-2,5-PDA and cis-2,6-PDA exist predominantly in a single conformation. These results seem to indicate that a certain degree of conformational flexibility of analogs of GLU is prerequisite for activation of, but not for binding to, the NMDA receptor. The results came from multiple reactions, including the reaction of Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1Application In Synthesis of Cis-piperidine-2,6-dicarboxylic acid)

Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Application In Synthesis of Cis-piperidine-2,6-dicarboxylic acid

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Liu, Gang; Campbell, Brian T.; Holladay, Mark W.; Ford Pulido, Julia M.; Hua, Helen; Gitnick, Dana; Gardner, Michael F.; James, Joyce; Breider, Mike A.; Brigham, Daniel; Belli, Barbara; Armstrong, Robert C.; Treiber, Daniel K. published their research in ACS Medicinal Chemistry Letters on December 13 ,2012. The article was titled 《Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases》.Quality Control of 1-Cyclopropylpiperidin-4-ol The article contains the following contents:

A series of potent, selective platelet-derived growth factor receptor-family kinase inhibitors was optimized starting from a globally selective lead mol. 4 through structural modifications aimed at improving the physiochem. and pharmacokinetic properties, as exemplified by 18b. Further clearance reduction via per-methylation of the α-carbons of a solubilizing piperidine nitrogen resulted in advanced leads 22a and 22b. Results from a mouse tumor xenograft, a collagen-induced arthritis model, and a 7 day rat in vivo tolerability study culminated in the selection of compound 22b (AC710) as a preclin. development candidate. In the experiment, the researchers used 1-Cyclopropylpiperidin-4-ol(cas: 851847-62-6Quality Control of 1-Cyclopropylpiperidin-4-ol)

1-Cyclopropylpiperidin-4-ol(cas: 851847-62-6) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. Quality Control of 1-Cyclopropylpiperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Huang, Xixian; Zhu, Nengwu; Wei, Xiaorong; Ding, Yang; Ke, Yixin; Wu, Pingxiao; Liu, Zehua published their research in Journal of Hazardous Materials on December 5 ,2020. The article was titled 《Mechanism Insight into Efficient Peroxydisulfate activation by Novel Nano Zero-valent Iron Anchored yCo3O4 (nZVI/yCo3O4) Composites》.SDS of cas: 826-36-8 The article contains the following contents:

Novel nano zero-valent iron anchored bio-matrix supported Co3O4 (nZVI/yCo3O4) composites were fabricated for tetracycline (TC) efficient degradation by activating peroxydisulfate (PS). The systematical characterizations verified that the nZVI/yCo3O4 composites with magnetism have higher surface area than yCo3O4 and pure Co3O4, contributing to more accessible active sites. Various catalytic parameters (nZVI mass ratio, leached ions, initial pH, catalyst dosage, PS concentration and coexisting anions) were thoroughly investigated. In nZVI/yCo3O4/PS system, 97.6%, 93.4% and 77.3% TC were degraded within 15 min at pH 3.0, 6.0 and 9.0, resp. Based on four successive degradation runs, the excellent mineralization rate and reusability of nZVI/yCo3O4 composites were mainly benefited from the suppressed metals leaching. The PS activated mechanisms were proposed as non-radicals (1O2) dominated pattern at acidic conditions and radicals (SO•-4) predominant pattern at alk. environment, which may be highly related to the electron donating capacity of nZVI at different pH and the M(n+1)+/Mn+ redox cycling between Fe or Co metal. The plausible degradation routes of TC were presented based on the detected intermediates. Overall, the synthesized heterogeneous nZVI/yCo3O4 composites can efficiently active PS at a wide pH range, and further broaden the application of Co-based catalysts in PS activation. After reading the article, we found that the author used Triacetonamine(cas: 826-36-8SDS of cas: 826-36-8)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.SDS of cas: 826-36-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Reference of 2-(Piperidin-4-yl)ethanolIn 2012 ,《Synthesis and structure-activity relationship of fused-pyrimidine derivatives as a series of novel GPR119 agonists》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Negoro, Kenji; Yonetoku, Yasuhiro; Moritomo, Ayako; Hayakawa, Masahiko; Iikubo, Kazuhiko; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki. The article conveys some information:

A series of fused-pyrimidine derivatives has been discovered as potent and orally active GPR119 agonists. A combination of the fused-pyrimidine structure and 4-chloro-2,5-difluorophenyl group provided the 5,7-dihydrothieno[3,4-d]pyrimidine 6,6-dioxide derivative I as a highly potent GPR119 agonist. Further optimization of the amino group at the 4-position in the pyrimidine ring led to the identification of 2-{1-[2-(4-chloro-2,5-difluorophenyl)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperidin-4-yl}acetamide (II) as an advanced analog. Compound II was found to have extremely potent agonistic activity and improved glucose tolerance at 0.1 mg/kg po in mice. The authors consider compound II and its analogs to have clear utility in exploring the practicality of GPR119 agonists as potential therapeutic agents for the treatment of type 2 diabetes mellitus. In the experiment, the researchers used 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Reference of 2-(Piperidin-4-yl)ethanol)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAKReference of 2-(Piperidin-4-yl)ethanol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Recommanded Product: 1-Methyl-4-piperidoneIn 2019 ,《Cocrystals and Salts of 3,5-Bis(pyridinylmethylene)piperidin-4-one with Aromatic Poly-Carboxylates and Resorcinols: Influence of Stacking Interactions on Solid-State Luminescence Properties》 appeared in Australian Journal of Chemistry. The author of the article were Das, Debarati; Biradha, Kumar. The article conveys some information:

Two bis-pyridyl-substituted α,β-unsaturated ketones form complexes with carboxylic acids and resorcinol derivatives The neutral acid-acid homosynthon was observed in only one complex out of the five acid-bis-pyridyl containing complexes studied here, while the -COO-···HOOC- synthon is dominant as it was observed in four complexes. The carboxylates self-assembled to form discrete dimeric, anionic, 1-dimensional chains and also exhibited mixed ionic H bonds. However, resorcinol derivatives displayed O-H···N H bonding to form tetrameric aggregates of bis-pyridyl ketone mols. and resp. co-formers, while 3,5-dihydroxy HOBz (DHBA) mols. formed 1-dimensional chains by clipping two mols. of ketones with three DHBA mols. Such clipping by the resorcinol derivatives promoted continuous π-π stacking interactions. Consequently, these materials emitted at higher wavelengths compared with the parent bis-pyridyl-substituted α,β-unsaturated ketones. After reading the article, we found that the author used 1-Methyl-4-piperidone(cas: 1445-73-4Recommanded Product: 1-Methyl-4-piperidone)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Recommanded Product: 1-Methyl-4-piperidone

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2014,Iwasaki, Takanori; Imanishi, Reiko; Shimizu, Ryohei; Kuniyasu, Hitoshi; Terao, Jun; Kambe, Nobuaki published 《Copper-Catalyzed Alkyl-Alkyl Cross-Coupling Reactions Using Hydrocarbon Additives: Efficiency of Catalyst and Roles of Additives》.Journal of Organic Chemistry published the findings.COA of Formula: C7H15NO The information in the text is summarized as follows:

Cross-coupling of alkyl halides with alkyl Grignard reagents proceeds with extremely high TONs of up to 1230000 using a Cu/unsaturated hydrocarbon catalytic system. Alkyl fluorides, chlorides, bromides, and tosylates are all suitable electrophiles, and a TOF as high as 31200 h-1 was attained using an alkyl iodide. Side reactions of this catalytic system, i.e., reduction, dehydrohalogenation (elimination), and the homocoupling of alkyl halides, occur in the absence of additives. It appears that the reaction involves the β-hydrogen elimination of alkylcopper intermediates, giving rise to olefins and Cu-H species, and that this process triggers both side reactions and the degradation of the Cu catalyst. The formed Cu-H promotes the reduction of alkyl halides to give alkanes and Cu-X or the generation of Cu(0), probably by disproportionation, which can oxidatively add to alkyl halides to yield olefins and, in some cases, homocoupling products. Unsaturated hydrocarbon additives such as 1,3-butadiene and phenylpropyne play important roles in achieving highly efficient cross-coupling by suppressing β-hydrogen elimination, which inhibits both the degradation of the Cu catalyst and undesirable side reactions. The experimental part of the paper was very detailed, including the reaction process of 2-(Piperidin-4-yl)ethanol(cas: 622-26-4COA of Formula: C7H15NO)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.COA of Formula: C7H15NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Xing, Hongjie; Gao, Shitao; Zhang, Jingji; Xu, Yu; Du, Huiwei; Zhu, Zejie; Wang, Jiangying; Yao, Yaxuan; Zhang, Suwei; Ren, Lingling published an article on February 15 ,2021. The article was titled 《Ultrasound-assisted synthesized BiFeO3 as FeOH+ promoted peroxymonosulfate activator for highly efficient degradation of tetracycline》, and you may find the article in Journal of Alloys and Compounds.SDS of cas: 826-36-8 The information in the text is summarized as follows:

A multiferroic BiFeO3 (BFO) catalyst was fabricated through a mild one-pot hydrothermal process with a bath-ultrasound assisted dissolution of Fe(NO3)3·9H2O for 30 min. X-ray photoemission spectroscopy revealed that the BFO (BFO-u) catalyst with US assisted dissolution of Fe(NO3)3·9H2O in the synthetic process exhibited high Fe2+ and OH- levels, which could be explained to be Fe3+ + H2O → Fe2+ + H+ + •OH. As a result, BFO-u catalyst activated potassium peroxymonosulfate (PMS) efficiently for degrading tetracycline hydrochloride. In particular, visible-light assisted activation of PMS over BFO-u catalyst exhibited the highest degradation rate constant, at 0.352 min-1. Species-trapping experiments revealed that the presence of PMS promoted the generation of •OH, •O-2 and 1O2 that all participated in degrading TCH, in which 1O2 was primarily contributed to the degradation Also, BFO-u catalyst was stable and recyclable and thus suitable for practical applications. In the part of experimental materials, we found many familiar compounds, such as Triacetonamine(cas: 826-36-8SDS of cas: 826-36-8)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.SDS of cas: 826-36-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Kumar, Aditya; Prasad, Ankush; Sedlarova, Michaela; Pospisil, Pavel published an article on January 31 ,2019. The article was titled 《Organic radical imaging in plants: Focus on protein radicals》, and you may find the article in Free Radical Biology & Medicine.Formula: C9H17NO The information in the text is summarized as follows:

Biomol. (lipid and protein) oxidation products formed in plant cells exposed to photooxidative stress play a crucial role in the retrograde signaling and oxidative damage. The oxidation of biomols. initiated by reactive oxygen species is associated with formation of organic (alkyl, peroxyl and alkoxyl) radicals. Currently, there is no selective and sensitive technique available for the detection of organic radicals in plant cells. Here, based on the analogy with animal cells, immuno-spin trapping using spin trap, 5,5-dimethyl-1-pyrroline N-oxide (DMPO) was used to image organic radicals in Arabidopsis leaves exposed to high light. Using antibody raised against the DMPO nitrone adduct conjugated with the fluorescein isothiocyanate, organic radicals were imaged by confocal laser scanning microscopy. Organic radicals are formed predominantly in the chloroplasts located at the periphery of the cells and distributed uniformly throughout the grana stack. Characterization of protein radicals by standard immunol. techniques using anti-DMPO antibody shows protein bands with apparent mol. weights of 32 and 34 kDa assigned to D1 and D2 proteins and two protein bands below the D1/D2 band with apparent mol. weights of 23 and 18 kDa and four protein bands above the D1/D2 band with apparent mol. weights of 41, 43, 55 and 68 kDa. In summary, imaging of organic radicals by immuno-spin trapping represents selective and sensitive technique for the detection of organic radicals that might help to clarify mechanistic aspects on the role of organic radicals in the retrograde signaling and oxidative damage in plant cell. The experimental part of the paper was very detailed, including the reaction process of Triacetonamine(cas: 826-36-8Formula: C9H17NO)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Formula: C9H17NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

《Insights on the nitrate reduction and norfloxacin oxidation over a novel nanoscale zero valent iron particle: Reactivity, products, and mechanism》 was written by Diao, Zeng-Hui; Qian, Wei; Lei, Ze-Xiang; Kong, Ling-Jun; Du, Jian-Jun; Liu, Hui; Yang, Jie-Wen; Pu, Sheng Yan. SDS of cas: 826-36-8 And the article was included in Science of the Total Environment on April 10 ,2019. The article conveys some information:

Herein, the application of a novel acid mine drainage-based nanoscale zero valent iron (AMD-based nZVI) for the remediation of nitrate and norfloxacin (NOR) was studied. Exptl. results indicated that the catalytic reactivity of AMD-based nZVI toward nitrate reduction was superior to that of iron salt-based nanoscale zero valent iron (Iron salt-based nZVI). The presence of ultrasound irradiation could significantly enhance the reactivity toward both the nitrate reduction and NOR oxidation processes. The optimal efficiencies of nitrate and NOR by AMD-based nZVI/US process could be kept 96 and 94% within 120 min, resp. Ammonia was identified as a major product in nitrate reduction process, while three oxidation products were observed in NOR degradation process. Both reduction reaction of nitrate from AMD-based nZVI and oxidation reaction of NOR from US-assisted Fenton system might be involved in AMD-based nZVI/US process. The AMD-based nZVI/US process showed a better performance on the removal of NOR compared with that of nitrate. The findings of the present work could be as a guide and show that AMD-based nZVI/US process is feasible for the remediation of both nitrate and NOR in real wastewater. After reading the article, we found that the author used Triacetonamine(cas: 826-36-8SDS of cas: 826-36-8)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.SDS of cas: 826-36-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem