Sutherland, Mathew published the artcileRational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics, SDS of cas: 2757618-86-1, the publication is ChemMedChem (2021), 16(7), 1116-1125, database is CAplus and MEDLINE.
Protein arginine N-Me transferase 4 (PRMT4) asym. dimethylates the arginine residues of histone H3 and nonhistone proteins. The overexpression of PRMT4 in several cancers had stimulated interest in the discovery of inhibitors as biol. tools and, potentially, therapeutics. Although several PRMT4 inhibitors had reported, most display poor selectivity against other members of the PRMT family of Me transferases. Herein, the structure-based design of a new class of alanine-containing 3-arylindoles such as I [R = Me, i-Pr, NMe2, etc.] as potent and selective PRMT4 inhibitors was reported, and described key structure-activity relationships for this class of compounds
ChemMedChem published new progress about 2757618-86-1. 2757618-86-1 belongs to piperidines, auxiliary class Boronic acid and ester, name is 1-((3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl)piperidine, and the molecular formula is C6H12Br2, SDS of cas: 2757618-86-1.
Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem