C-5 Substituted heteroaryl 3-pyridinecarbonitriles as PKC胃 inhibitors: Part I was written by Subrath, Joan;Wang, Daniel;Wu, Biqi;Niu, Chuansheng;Boschelli, Diane H.;Lee, Julie;Yang, Xiaoke;Brennan, Agnes;Chaudhary, Divya. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Quality Control of N,N-Dimethylpiperidin-4-amine This article mentions the following:
We earlier reported that 3-pyridinecarbonitriles with a 4-methylindolyl-5-amino group at C-4 and a Ph group at C-5 were inhibitors of PKC胃. Keeping the group at C-4 of the pyridine core constant, we varied the water solubilizing group on the Ph ring at C-5 and then replaced the C-5 Ph ring with several monocyclic heteroaryl rings, including furan, thiophene and pyridine. Analog 6e (I) with a 4-methylindol-5-ylamino group at C-4 and a 5-[(4-methylpiperazin-1-yl)methyl]-2-furyl group C-5 had an IC50 value of 4.5 nM for the inhibition of PKC胃. In the experiment, the researchers used many compounds, for example, N,N-Dimethylpiperidin-4-amine (cas: 50533-97-6Quality Control of N,N-Dimethylpiperidin-4-amine).
N,N-Dimethylpiperidin-4-amine (cas: 50533-97-6) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Quality Control of N,N-Dimethylpiperidin-4-amine
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem