Su, Wenji published the artcileTriaging of DNA-Encoded Library Selection Results by High-Throughput Resynthesis of DNA-Conjugate and Affinity Selection Mass Spectrometry, Application of tert-Butyl piperidin-4-ylcarbamate, the main research area is synthesis DNA Conjugate Mass Spectrometry.
DNA encoded library (DEL) technol. allows for rapid identification of novel small-mol. ligands and thus enables early-stage drug discovery. DEL technol. is well-established, numerous cases of discovered hit mols. have been published, and the technol. is widely employed throughout the pharmaceutical industry. Nonetheless, DEL selection results can be difficult to interpret, as library member enrichment may derive from not only desired products, but also DNA-conjugated byproducts and starting materials. Note that DELs are generally produced using split-and-pool combinatorial chem., and DNA-conjugated byproducts and starting materials cannot be removed from the library mixture Herein, we describe a method for high-throughput parallel resynthesis of DNA-conjugated mols. such that byproducts, starting materials, and desired products are produced in a single pot, using the same chem. reactions and reagents as during library production The low-complexity mixtures of DNA-conjugate are then assessed for protein binding by affinity selection mass spectrometry and the mol. weights of the binding ligands ascertained. This workflow is demonstrated to be a practical tool to triage and validate potential hits from DEL selection data.
Bioconjugate Chemistry published new progress about DNA-encoded chemical library. 73874-95-0 belongs to class piperidines, name is tert-Butyl piperidin-4-ylcarbamate, and the molecular formula is C10H20N2O2, Application of tert-Butyl piperidin-4-ylcarbamate.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem