Sternfeld, Francine; Baker, Raymond; Broughton, Howard B.; Guiblin, Alexander R.; Jelley, Richard A.; Matassa, Victor G.; Reeve, Austin J.; Beer, Margaret; Stanton, Josephine a. published their research in Bioorganic & Medicinal Chemistry Letters on August 6 ,1996. The article was titled 《The chemical evolution of N,N-dimethyl-2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethylamine (L-741,604) and analogs: potent and selective agonists for 5-HT1D receptors》.Reference of Methyl 2-(1-methylpiperidin-4-yl)acetate The article contains the following contents:
Optimization of a series of 5-(heterocyclyl)tryptamines led to the identification of the sym. substituted, N-4 linked 1,2,4-triazole as the best indole C-5 substituent for 5-HT1D receptor affinity and selectivity. The triazole I is the most potent and selective, orally bioavailable, 5-HT1D receptor agonist identified to date, showing an order of magnitude greater potency than the clin. compound sumatriptan with improved subtype selectivity. The experimental part of the paper was very detailed, including the reaction process of Methyl 2-(1-methylpiperidin-4-yl)acetate(cas: 95533-25-8Reference of Methyl 2-(1-methylpiperidin-4-yl)acetate)
Methyl 2-(1-methylpiperidin-4-yl)acetate(cas: 95533-25-8) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Reference of Methyl 2-(1-methylpiperidin-4-yl)acetate
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem