Steiner, Gerd published the artcileTricyclic epines. Novel (E)- and (Z)-11H-dibenz[b,e]azepines as potential central nervous system agents. Variation of the basic side chain, Name: (1-Methylpiperidin-3-yl)methanamine, the publication is Journal of Medicinal Chemistry (1986), 29(10), 1877-88, database is CAplus and MEDLINE.
Dibenzazepinylideneacetonitriles I (R = alkylamino, aminoalkoxy; R1 = H, Me, Cl; R2 = H, Cl) were prepared and their pharmacol. activities were determined The introduction of the cyanomethylene group into the 11-position of the 11H-dibenz[b,e]azepine framework was carried out by a Wittig-Horner reaction under mild conditions. The (E),(Z) isomers were separated by fractional crystallization, assignment being achieved by X-ray anal. I (R = 4-methyl-1-piperazinyl, R1 = R2 = H; R1 = 3-Me 3-Cl, R2 = H; R1 = H, R2 = 8-Cl) show neuroleptic activity 2-7 times that of clozapine. The screening included tests for sedative and anticholinergic activity in mice, apomorphine and tryptamine antagonism in rats, and muscle-relaxing activity in rabbits. The divergence in the activity profile in the case of the separated (E),(Z) isomers has been observed as an interesting new aspect: the (Z) isomers show a significantly higher sedative and muscle-relaxant activity, whereas the (E) isomers possess a higher anticholinergic efficacy and somewhat greater apomorphine antagonism. Broad changes in the basic side chain were made in order to investigate structure-activity relationships. The important geometrical parameters for the mols., obtained by X-ray anal., were compared with the corresponding features in dopamine agonists and antagonists.
Journal of Medicinal Chemistry published new progress about 14613-37-7. 14613-37-7 belongs to piperidines, auxiliary class Piperidine,Amine, name is (1-Methylpiperidin-3-yl)methanamine, and the molecular formula is C25H23NO4, Name: (1-Methylpiperidin-3-yl)methanamine.
Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem