(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Reference of 86069-86-5
Design of short linear peptides that show hydrogen bonding constraints in water was written by Song, Ben-Ben;Kibler, Patrick;Malde, Alpeshkumar;Kodukula, Krishna;Galande, Amit K.. And the article was included in Journal of the American Chemical Society in 2010.Reference of 86069-86-5 The following contents are mentioned in the article:
Using a combination of an aromatic amino acid, a homoserine side chain, and a D-amino acid, a series of linear tetrapeptides were designed that adopt an “Hse turn” in water. The conformation was stabilized by intramol. hydrogen bonds even in the presence of surrounding water mols. In particular, the peptide with sequence H-Abz-Homoser-Ser-D-Gln-NH2 showed significant through-space interactions and its free energy of folding is estimated to be on the order of -4 kcal/mol. We report the design of the tetrapeptides using a novel mimicry approach and their characterization based on NMR spectroscopy and MD simulations. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Reference of 86069-86-5).
(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Reference of 86069-86-5
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem