Song, Aimin published the artcileA Novel and Rapid Encoding Method Based on Mass Spectrometry for “”One-Bead-One-Compound”” Small Molecule Combinatorial Libraries, SDS of cas: 158922-07-7, the main research area is combinatorial library decoding technique mass spectrometry; solid phase synthesis decoding combinatorial library mass spectroscopy; coding block synthesis deconvolution combinatorial library solid phase; single bead decoding combinatorial library.
A method for the preparation and encoding of readily deconvoluted combinatorial libraries is discussed. Beads are prepared with topol. segregated regions – an inner region to which is bound coding tags and an outer segment to which the library compound is bound. Coding blocks are attached to the inner resin by a cleavable methionine-containing linker; the coding blocks are chosen to have similar reactivities to the building blocks incorporated in the synthesis of the combinatorial library. Synthesis of the library leads to the functionalization of the library-containing portion of the resin bead and the coding portion of the resin bead. Cleavage of the linkers for the coding blocks from the resin bead by Edman degradation with cyanogen bromide yields lactones whose mass is determined by FT-MALDI mass spectroscopy. Anal. of the lactones isolated from a given bead yields the mass of each of the fragments present; by careful choice of coding blocks and reactants, the identities of the building blocks incorporated into a library bead and of the library member attached to that bead can be readily derived from the fragment masses. A combinatorial library is prepared and tested for the binding of library members to streptavidin; seventeen of the compounds are found to bind strongly to streptavidin by a colorometric assay and identified unambiguously by the library encoding method described here.
Journal of the American Chemical Society published new progress about Amines Role: CMB (Combinatorial Study), RCT (Reactant), RACT (Reactant or Reagent). 158922-07-7 belongs to class piperidines, name is 1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-3-carboxylic acid, and the molecular formula is C21H21NO4, SDS of cas: 158922-07-7.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem