With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.948894-26-6,4-Methylpiperidine-4-carbonitrile hydrochloride,as a common compound, the synthetic route is as follows.
948894-26-6, Example 28 (0905) 1 -(2-((2-ethoxy-4-(4-methyl-4 -/-1 ,2,4-triazol-3-yl)phenyl)amino)-6-methylpyrido[3,4-c/|pyrimidin-8- (0906) (0907) To a solution of 8-chloro-A/-(2-ethoxy-4-(4-methyl-4 -/-1 ,2,4-triazol-3-yl)phenyl)-6-methylpyrido[3,4- c/|pyrimidin-2-amine (Preparation 1 , 25 mg, 0.063 mmol) in NMP (2 ml_) was added 4- methylpiperidine-4-carbonitrile (20 mg, 0.126 mmol) and triethylamine (0.044 ml_, 0.316 mmol). The reaction was heated to 100 in a closed cap vial for 18 hours. Further 4-methylpiperidine-4- carbonitrile hydrochloride (40 mg, 0.252 mmol) was added and the reaction heated at 120 for a further 5 hours. The reaction mixture was diluted with EtOAc and water. The organic layer was dried (MgS04) and concentrated in vacuo. The residue was purified by silica gel column chromatography eluting with 0-50% EtOAc in cyclohexane followed by elution through an SCX-2 cartridge using MeOH followed by 1 M NH3 in MeOH. The residue was further purified by silica gel column chromatography eluting with 0-1 5% MeOH in EtOAc followed by elution through an SCX- 2 cartridge using MeOH followed by 1 M NH3 in MeOH to afford the title compound (5.1 mg, 17%). 1 H NMR (500 MHz, MeOH-d4): delta ppm 9.13 (s, 1 H), 8.80 (d, J = 8.5 Hz, 1 H), 8.56 (s, 1 H), 7.38 (d, J = 2.0 Hz, 1 H), 7.36 (dd, J = 8.5, 2.0 Hz, 1 H), 7.04 (s, 1 H), 4.70 (br d, J = 13.0 Hz, 2H), 4.29 (q, J = 7.0 Hz, 2H), 3.88 (s, 3H), 3.26 (t, J = 13.0 Hz, 2H), 2.50 (s, 3H), 2.1 0 (br d, J = 13.0 Hz, 2H), 1 .92 (td, J = 13.0, 3.5 Hz, 2H), 1 .56 (t, J = 7.0 Hz, 3H), 1 .51 (s, 3H). (0908) HRMS (ESI) MS m/z calcd for C26H31 N9O [M+2H]/2+ 242.632, found 242.6321 . (0909) MPS1 IC50 (muMu): 0.002
The synthetic route of 948894-26-6 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; WOODWARD, Hannah; INNOCENTI, Paolo; NAUD, Sebastien; BLAGG, Julian; HOELDER, Swen; WO2015/128676; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem