With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91419-48-6,tert-Butyl 4-carbamoylpiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.,91419-48-6
The amide (20 g, 76.3 mmol) was dissolved in 1,4-dioxane with heating and the clear solution placed in a 60 0C oil bath. Lawesson’s Reagent was added (15.43 g, 38.15 mmol) and the solution stirred for 2 hours. The solution was cooled to RT, poured into 8:1 water : saturated NaHCO3, followed by aqueous/EtOAc work-up and silica gel chromatography (EtOAc : hexanes (1:4)) to give the titled compound.
The synthetic route of 91419-48-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK & CO., INC.; WO2007/64553; (2007); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem