With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.908245-03-4,Methyl 6-methylpiperidine-3-carboxylate,as a common compound, the synthetic route is as follows.
908245-03-4, This residue was dissolved in CH2C12 (30 mL) and chilled in an ice bath. To this stirred solution was added DMAP (0.194 g, 1.59 mmol), followed by TEA (6.64 mL, 47.7 mmol) portion wise. A suspension formed when TEA was added. This mixture was chilled to 15 C. To the resulting suspension was added benzyl chloroformate (2.72 mL, 19 mmol) dropwise over a 15 min period such that the temperature of the mixture was kept at 15- 20 C. After completion of benzyl chloroformate addition, the mixture was stirred chilled with an ice bath for another 30 min and then at ambient temperature for 1 h. This mixture was washed with 100 mL of cold IN HC1. The organic was concentrated in vacuo. The residue was partitioned between toluene (100 mL), MTBE (100 mL), and water (50 mL). The organic was washed with brine, dried over MgS04, filtered, and concentrated in vacuo to give an oil (2.5 g) as the crude (NMR showed ?^3: 1 cis/trans ratio of isomers). Isomer was separated by silica gel column chromatography using gradient elution of EtOAc in hexane and gave 840 mg cis isomer (112) and 450 mg trans isomer (113).
The synthetic route of 908245-03-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ADVINUS THERAPEUTICS LIMITED; BARAWKAR, Dinesh; BENDE, Tanushree; ZAHLER, Robert; BANDYOPADHYAY, Anish; SARANGTHEM, Robindro Singh; DOSHI, Jignesh; WAMAN, Yogesh; JADHAV, Rushikesh; SINGH, Umesh Prasad; WO2012/127506; (2012); A1;,
Piperidine – Wikipedia
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