With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.90802-45-2,3-Aminopiperidine-2,6-dione hydrobromide,as a common compound, the synthetic route is as follows.
Add 55.0 g (0.263 mol) of 3-amino-2,6-piperidinone hydrobromide to a 1000 ml reaction flask.Triethylamine 75ml, 200ml acetonitrile, stirred and mixed at room temperature, heated to 80 C, adding a mixture of 72.1g (0.263mol) of methyl 2-bromomethyl-3-nitrobenzoate and 150ml of acetonitrile, heat preservation reaction for 10h, Cold to room temperature,Slowly add 200ml of water and stir for 0.5h.The product was obtained as an off-white solid, 49.6 g, yield 65.2%.
90802-45-2, The synthetic route of 90802-45-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Shijiazhuang Duen Pharmaceutical Technology Co., Ltd.; Fang Yu; Du Yumin; (8 pag.)CN109776493; (2019); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem