With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.885279-92-5,1-Boc-1,8-diaza-spiro[4.5]decane,as a common compound, the synthetic route is as follows.,885279-92-5
tert-Butyl 8-quinoxalin-2-yl-1.8-diazaspiro[“4.5]decane-l-carboxylate (B-I); To a solution of 500 mg (2.08 mmol) A^ in 5 mL DMF was added 410 mg (2.5 mmol) 2-chloroquinoxoline and 575 mg (4.2 mmol) K2CO3. After heating the mixture for 3 h at 1000C, the reaction was cooled to room temperature, and dumped into a separatory funnel with EtOAc and water. The layers were separated, the aqueous was extracted with EtOAc, the combined organic extracts were washed with brine, dried over Na2SO^ and concentrated by rotary evaporation. The residue was purified by column chromatography on silica gel (EtOAc/hexanes) to provide B-I as a yellow solid. Data for B^ I: LCMS: rt = 2.34 min; m/z (M + H) = 369.1, found; 369.2 required.
The synthetic route of 885279-92-5 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; MERCK & CO., INC.; WO2007/25069; (2007); A2;,
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