With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.85908-96-9,N-Boc-2-Piperidone,as a common compound, the synthetic route is as follows.
85908-96-9, Tert-butyl 2-oxopiperidine-1-carboxylate (8.22 g, 41.3 mmol) was dissolved in dry tetrahydrofuran (80 mL), then the solution was cooled to -78 C and to this was added dropwise LiHMDS (1.0 M in THF, 103 mL, 103 mmol) followed by stirring for 20 minutes followed by 3-bromoprop-1-ene (10.7 mL, 124 mmol) and the resulting reaction was stirred at this temperature for 15 minutes, then moved to room temperature and quenched with water (15 mL). The reaction mixture was then concentrated under reduced pressure and the resulting residue was diluted with water (30 mL) and extracted with ethyl acetate (50 mL x 3), then the organic phases were combined. Next, the combined organic phases were washed with saturated brine (50 mL), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. The resulting residue was then subjected to silica gel column chromatography (EtOAc / PE (v / v) = 1/50) to give the title compound as a yellow oil (3.95 g, 35%).
The synthetic route of 85908-96-9 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Li Minxiong; Hu Haiyang; Dai Weilong; Li Xiaobo; Wang Tingjin; Wu Yanjun; (93 pag.)CN104974163; (2017); B;,
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