79098-75-2, 3-Piperidin-4-yl-3,4-dihydro-1H-quinazolin-2-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EXAMPLE 89 (+)-N-(1-(1-(3-Fluorobenzyl)-4-methyl-lH-imidazol-2-yl)-2-(7-methyl-lH- indazol-5-yl) ethyl)-4-(2-oxo-1, 2-dihydroquinazolin-3 (4H)-yl) piperidine-1- carboxamide tert-Butyl 1-(1-(3-fluorobenzyl)-4-methyl-11 J-imidazol-2-yl)-2-(7-methyl- 2- ( (2- (trimethylsilyl) ethoxy) methyl)-2H-indazol-5-yl) ethylcarbamate (20.0 mg, 0.034 mmol) was dissolved in a minimum amount of ethyl acetate, and treated with hydrochloric acid (4 N in dioxane, 1.0 mL). The mixture was stirred under nitrogen for 3 days. After removal of the solvents, the crude mixture was treated with diethyl ether to give a precipitate which was filtered. The resulting solid was dissolved in dimethylformamide (1.0 mL), cooled to 0C, and treated with carbonyl diimidazole (6.0 mg, 0.037 mmol, 1.1 equiv) and N’N- diisopropylethylamine (24. 3 L, 3 equiv). The reaction was stirred for 5 min at 0C, warmed to room temperature, stirred for 10 min, and treated with 3- (piperidin-4-yl) -3,4-dihydroquinazolin-2 (1H)-one (8.5 mg, 0.037 mmol, 1.1 equiv). The mixture was stirred at room temperature overnight. The solvent was evaporated and the residue purified by column chromatography to afford 16.1 mg (74%, 2steps).’H-NMR (CD30D, 500 MHz) 8 1.50-1. 68 (m, 4H), 2.27 (s, 3H), 2.46 (s, 3H), 2.77 (m, 2H), 3.20 (m, 2H), 4.01-4. 16 (m, 2H), 4.20 (s, 2H), 4.32- 4.43 (m, 1H), 5.13-5. 22 (m, 2H), 6.60-6. 67 (m, 2H), 6.70 (s, 1H), 6.76-6. 86 (m, 2H), 6.87-6. 94 (m, 1H), 6.96 (dd, J=8. 3,6. 7, 1H), 7.07-7. 14 (m, 2H), 7.16 (dd, J= 7.9, 7.6, 1H), 7.25 (s, 1H), 7.92 (s, 1H). Mass spec.: 621.4 (MH) +.
79098-75-2 3-Piperidin-4-yl-3,4-dihydro-1H-quinazolin-2-one 11042597, apiperidines compound, is more and more widely used in various.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2005/56550; (2005); A2;,
Piperidine – Wikipedia
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