Some tips on 768-66-1

768-66-1, 2,2,6,6-Tetramethylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,768-66-1

n-BuLi (2.5M in hexanes, 2.27 mL, 5.67mmol) was added to cold(-50 C) anhydrous THF (20 mL) under nitrogen. 2,2, 6, 6-Tetramethylpiperidine (0.957, 0.8 g, 5.67mmol) was then added and the mixture stirred at-78 C for 30 min. A solution of the title compound of Preparation 53 (0.5 g, 2.68mmol) in THF (5 mL) was added dropwise and the mixture was stirred at-78 C for 60 min. Then, iodine (1.51 g, 5.94mmol) was added and the mixture was stirred at that temperature for 90 min and then warmed to r. t. The mixture was quenched with methanol and the residual iodine destroyed with sat. sodiumthiosulphate (aq. ). The mixture was concentrated in vacuo, partitioned between ethyl acetate and water and the organic layer was washed with water, dried and evaporated to give an oil which was purified by column cromatography (n-Hex/EtOAc 4: 1) to afford the title compound (87% yield) as an oil which crystallised. 8 (CDCI3) : 4.22 (s, 3H), 7.47 (m, 3H), 7.96 (m, 2H), 8.29 (s,1 H).

768-66-1 2,2,6,6-Tetramethylpiperidine 13035, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; ALMIRALL PRODESFARMA, S.A.; WO2005/49581; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem