768-66-1, 2,2,6,6-Tetramethylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
768-66-1, Example 12 (+)-Dimenthyl (1S, 2S)-Cyclopropane-1,2-dicarboxylate. A 2.5 M solution of butyllithium in hexane (56.9 ml, 142.2 mmol) was added to 180 ml of dry tetrahydrofuran (THF), cooled to -20C. 2,2,6,6-Tetramethylpiperidine (24 ml, 142.2 mmol) was added dropwise over a period of 10 minutes.. The resulting solution of lithium 2,2,6,6-tetramethylpiperidide (LTMP) was cooled to -78C and stirred for 30 minutes.. A solution of (-)-dimenthyl succinate (26.75 g, 67.7 mmol) in THF (60 ml) was then added over a period of 1 h.. The resulting yellow solution was stirred for 1 h.. Thereafter, bromochloromethane (4.39 ml, 67.7 mmol) was added and the reaction mixture stirred for 2 h.. The reaction was quenched by adding isobutyraldehyde (22.46 ml, 27.08 mmol).. After stirring for further 30 minutes, the mixture was poured into ice-cooled 1N hydrochloric acid (250 ml) and the aqueous layer was extracted with diethyl ether (3×150 ml).. The combined organic layers were washed with saturated sodium chloride (250 ml), dried over sodium sulphate and concentrated with a rotary evaporator.. The residue was chromatographed on silica gel (petroleum ether/diethyl ether = 98/2).. An additional flash chromatography on silica gel (petroleum ether/diethyl ether = 98/2) afforded the pure title compound. Yield 33% mp: 95-96C [alpha]D25 = -18.8 (c = 1, CHCl3) 1H-NMR (CDCl3) delta: 0.70-2.20-(complex, 20 H); 0.75 (d, 6H, J = 7 Hz); 0.9 (d, 9H, J = 6.8 Hz); 2.15 (dd, 2H, J = 7.6, 8.7 Hz); 4.7 (dt, 2H, J = 4.3, 10.7 Hz). 13C-NMR (CDCl3) delta: 15.2; 16.4; 20.6; 21.9; 22.2; 23.6; 26.3; 31.3; 34.2; 40.8; 47.0; 74.9; 171.2.
768-66-1 2,2,6,6-Tetramethylpiperidine 13035, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; Newron Pharmaceuticals S.p.A.; EP1424333; (2004); A1;,
Piperidine – Wikipedia
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