74892-82-3, (2R,4R)-Ethyl 4-methylpiperidine-2-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
74892-82-3, 35kg of tetrahydrofuran,Add to the 50L reactor,2kg of N2-(3-methyl-8-quinolinesulfonyl)-NG-nitro-L-arginine was added.After warming up and refluxing,Cool down to -30 C,Keep 2 kg of phosphorus oxychloride at this temperature.Stir for 2 hours with heat.TLC test,The material points disappear,Then add 1.5 kg of ethyl (2R,4R)-4-methyl-2-piperidinecarboxylate at this temperature.Stir for 2 hours with heat.TLC detects the reaction completely,Layered with saturated brine,The organic phase is concentrated under reduced pressure to an oil.Add saturated NaHCO3 solution and 35 kg of dichloromethane,Layered,The organic phase is washed to neutral,Dry over anhydrous sodium sulfate,Distilling the solvent under reduced pressure,Obtaining a yellow oily product,The content is 81.5%,The yield was 72.6%.
74892-82-3 (2R,4R)-Ethyl 4-methylpiperidine-2-carboxylate 10313307, apiperidines compound, is more and more widely used in various.
Reference£º
Patent; Tianjin Pharmaceutical Institute Pharmaceutical Co., Ltd.; Wang Yuewei; Xi Pengyan; Wang Yang; Jia Xianyong; Zhao Zhao; (7 pag.)CN109912570; (2019); A;,
Piperidine – Wikipedia
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