With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.73874-95-0,tert-Butyl piperidin-4-ylcarbamate,as a common compound, the synthetic route is as follows.
A suspension of 1.0 eq of 183 in 5 mL of dry DMF was prepared. While stirring, 1.2 eq of triethylamine was added followed by 1.2 eq of 184. The mixture was stirred at rt for 40 min and 30 mL OF H2O was added. The mixture was then extracted with EtOAc (3 x 50 mL). The combined organic extracts were dried over MGS04 and vacuum filtered. The filtrate was rotary evaporated and flash chromatographed on silica using 20% EtOAc/hexanes as eluent. After concentration and drying under vacuum of the fractions containing product, a white solid was obtained as 185.
73874-95-0, As the paragraph descriping shows that 73874-95-0 is playing an increasingly important role.
Reference£º
Patent; ELAN PHARMACEUTICALS, INC.; WO2004/98589; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem