With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.72752-52-4,2-Piperidinobenzonitrile,as a common compound, the synthetic route is as follows.
72752-52-4, To a well stirred suspension of magnesium turnings (67.7 g, 2.80 mol) in THF (30 mL), benzyl chloride (l mL) and catalytic amount of iodine was added at 25-30 C. The contents were stirred for 30 min at 35-40 C. Thereafter, a solution of benzyl chloride (306.0 g, 2.40 mol) dissolved in a mixture of THF (150 mL) and toluene (450 mL) was added, mainraining the intemal temperature of reaction mixture in between 35-45 C. Stirred the reaction mixture for another 2h at 35-40 C and cooled to 25-30 C. Thereafter a solution of nitrile 4 (150,0 g, 0.80 mol) dissolved in THF (150 mL) and toluene (450 mL) was added at 25-45 C. The reaction mixture was cooled to 25-30 C and stirred for 16 h at 25-30 C. The above suspension was added over a mixture of aqueous NH4CI (25% wlw, 600 mL) and aqueous ammonia (300 mL) at 5-15 C. The inorganics were removed through filtration and washed with water (250 mL). The organic layer was separated and concentrated under vacuum to obtained 9 (204.4 g).
As the paragraph descriping shows that 72752-52-4 is playing an increasingly important role.
Reference：
Article; Sundaram, Dhanraj T. S. S.; Mitra, Jayati; Rajesh; Islam, Aminul; Prabahar, Koilpillai Joseph; Rao, Battula Venkateswara; Douglas, Sanasi Paul; Synthetic Communications; vol. 45; 18; (2015); p. 2092 – 2098;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem