63845-28-3, 2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
(3-Chloropyrazin-2-yl)(2-phenylquinolin-7-yl)-methanamine (120.00 mg, 0.35 mmol), EDC (100.64 mg, 0.53 mmol) and HOBt (47.29 mg, 0.35 mmol) were suspended in CH2Cl2 use CH2C12(2 mL) and charge with DIEA (122.00 muL, 0.70 mmol) followed by the addition of l-JV-Cbz-4-piperidineacetic acid (127.56 mg, 0.46 mmol). The reaction mixture was stirred at rt for 16 h. The reaction mixture was diluted with CH2Cl2 (10 mL) and washed with saturated NaHCO3 (2 x 20 mL) and brine (2 x 20 mL). The organic layer was dried over Na2SO4 and concentrated in vacuo. The crude product was purified by a 10 g Jones silica gel (wetted with 50% EtOAc / Hexane, dried loaded onto silica, and run with 60% EtOAc / Hexanes – > 70% EtOAc / Hexanes). The product was evaporated in vacuo which afforded the title compound; 1H NMR (400 MHz, CHLOROFORM-d) delta 8.56 (1 H, d, J=IAT), 8.39 (1 H, d, J= 2.50), 8.23 (1 H, d, J= 4.77), 8.11 (2 H, d, J= 7.06), 7.85 (3 H, dd, J= 8.60, J= 8.38), 7.74 (1 H, s), 7.50 (3H, m), 7.32 (6H, m), 6.78 (1 H, d, J= 7.76), 5.10 (2 H, s), 4.11 (2 H, m), 2.75 (2 H, m), 2.21 (2 H, d, J= 7.00), 2.01 (1 H, m), 1.67 (2 H, m), 1.15 (2 H, d, J= 8.921); MS (ES+): m/z 605.96/606.98/608.93 (100/40/15) [MH+]; HPLC: tR = 3.33 min. (OpenLynx, nonpolar_5min.).
63845-28-3, 63845-28-3 2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid 1502086, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; OSI PHARMACEUTICALS, INC.; WO2009/91939; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem