With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61995-20-8,Benzyl 3-oxopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.,61995-20-8
To a solution of benzyl 3-oxopiperidine-1-carboxylate (30 g, 129 mmol) inMeOH (130 mL) and H20 (l7OmL) was added (NH4)2C03 (24.8 g,258 mmol) and KCN (16.7g, 258mmo1). The solution was stirred at 40 C in a sealed tube for 48 h,and then the resulting solid was filtered and washed with water(1 L). The benzyl 2,4-dioxo- 1,3 ,7-triazaspiro [4.51 decane7-carboxylate was obtained and dried in vacuo.1H NMR (400 MHz, CD3OD) 3 7.35 (br. s.,5H),5.14 – 5.07 (m, 2H), 4.60 (br. s., 1H), 3.84 (br. s., 1H), 3.49 – 3.34 (m,1H), 3.25 – 3.10 (m, 1H),2.20 – 1.93 (m, 1H), 1.92 – 1.53 (m, 3H) ppm.
As the paragraph descriping shows that 61995-20-8 is playing an increasingly important role.
Reference：
Patent; MERCK SHARP & DOHME CORP.; LIU, Jian; KOZLOWSKI, Joseph; KIM, Ronald; GAO, Xiaolei; BOGA, Sobhana Babu; YU, Younong; WU, Hao; LIU, Shilan; YANG, Chundao; (102 pag.)WO2016/164284; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem