With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61995-20-8,Benzyl 3-oxopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.,61995-20-8
Intermediate 11Phenylmethyl 3-{[2-({[(1 ,1-dimethylethyl)oxy]carbonyl}amino)ethyl]amino}-1 – piperidinecarboxylate (D11) Phenylmethyl 3-oxo-i-piperidinecarboxylate (5 g, 21.44 mmol) was dissolved in a mixture of methanol (200 ml) and acetic acid (1.227 ml, 21.44 mmol). 1 ,1- dimethylethyl (2-aminoethyl)carbamate (10.30 g, 64.3 mmol) was added and sodium triacetoxyborohydride (11.36 g, 53.6 mmol) was also added after stirring for 1 hour. The reaction mixture was allowed to stir for a further 4 hours. Sodium bicarbonate (9.00 g, 107 mmol) was added to the reaction and the resulting mixture was concentrated in vacuo. The resulting residue was redissolved using DCM and water. The mixture was basified to pH 14 using 2M NaOH and the aqueous layer was extracted with DCM. The combined organic extracts was passed through a hydrophobic frit and concentrated in vacuo. The resulting residue was purified by silica column chromatography (Biotage SP4, eluting with a gradient from 0-20% MeOH in DCM) to give the title compound as a yellow oil (7.85 g, 20.80 mmol, 97 % yield).MS ES+ve m/z 275 (M+H)1H NMR (400 MHz, DMSO-D6) delta ppm 1.2 (m, 1 H) 1.4 (m, 1 H) 1.4 (s, 9 H) 1.6 (m, 2 H) 1.8 (m, 1 H) 2.4 (m, 1 H) 2.6 (m, 2 H) 2.7 (m, 1 H) 2.9 (m, 3 H) 3.7 (m, 1 H) 3.8 (m, 1 H) 5.1 (s, 2 H) 6.7 (m, 1 H) 7.3 (m, 5 H)
As the paragraph descriping shows that 61995-20-8 is playing an increasingly important role.
Reference：
Patent; GLAXO GROUP LIMITED; BESWICK, Paul, John; GLEAVE, Robert, James; WO2010/91721; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem