503614-91-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.503614-91-3,Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate,as a common compound, the synthetic route is as follows.
Intermediate-E (35g, 0.0716 moles) is suspended in 30 % aq. ammonia solution. Mixture was heated to 80-90C in an autoclave. Aqueous ammonia develops in- build pressure ofl-2 kg. Progress of the reaction is monitored on TLC/HPLC. When reaction was completed in -l0 hrs, reaction mass is cooled to RT and diluted with water. Product is filter and washed with water, dried at 60-65 c to obtain crude apixaban 23-25 gm with HPLC purity 98.5%. This crude product contains acid impurity approx-1.0-l.5%. Crude apixaban is further dissolved in MDC and washed with 2.0-5.0% bicarbonate solution. MDC layer is then concentrated under reduced pressure and crystallize using mixture of solvents methanol water to obtain pure apixaban with l-IPLC purity >99% (yield 6 1%).
503614-91-3 Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 22240488, apiperidines compound, is more and more widely used in various.
Reference£º
Patent; WANBURY LTD.; NITIN SHARADCHANDRA PRADHAN; SACHIN ULHAS SONAVANE; DAYAGHAN GHANGADHAR PATIL; UTTAM SAKHARAM PUJARI; RAVINDRA BHAUSAHEB PAGIRE; WO2015/111073; (2015); A3;,
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