496807-97-7,496807-97-7, 3,3-Difluoropiperidine hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 3,3-difluoropiperidine hydrochloride (518 mg) in DMF (15 mL) was added cesium carbonate (3.21 g) and (3-bromopropoxy)-tert-butyldimethylsilane (0.838 mL). The resulting reaction mixture was heated to 50 C. for 1.5 hours before cooling back to room temperature. Water and ethyl acetate were added to the reaction mixture. The mixture was extracted with ethyl acetate (2¡Á). The combined organics were washed with water (2¡Á), brine, dried over magnesium sulfate, filtered and concentrated. Purification by flash chromatography (ISCO, 0 to 40% ethyl acetate in hexanes with 1% triethylamine) gave the desired product (612 mg). 1H NMR (400 MHz, CDCl3): delta (ppm) 4.20 (t, 1H), 3.71-3.64 (m, 2H), 3.46 (t, 1H), 2.62 (t, 1H), 2.50-2.47 (m, 1H), 2.44-2.42 (m, 1H), 2.05-1.98 (m, 1H), 1.91-1.82 (m, 2H), 1.77-1.67 (m, 4H), 0.89 (d, 9H), 0.05 (s, 3H), 0.04 (s, 3H).
As the paragraph descriping shows that 496807-97-7 is playing an increasingly important role.
Reference£º
Patent; MSD Italia S.R.L.; Merck Sharp & Dohme Corp.; Rudd, Michael T.; McCauley, John; Liverton, Nigel; Grise-Bard, Christiane; Brochu, Marie-Christine; Charron, Sylvie; Aulakh, Virender; Bachand, Benoit; Beaulieu, Patrick; Zaghdane, Helmi; Han, Yongxin; Ferrara, Marco; Harper, Steven; Summa, Vincenzo; Chackalamannil, Samuel; Venkatraman, Srikanth; Shah, Unmesh; Velazquez, Francisco; (211 pag.)US9328138; (2016); B2;,
Piperidine – Wikipedia
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