With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.392331-89-4,1-Boc-3-methylaminopieridine,as a common compound, the synthetic route is as follows.
3-(N-Acetyl-N-methylamido)piperidine was prepared from N3-Cbz protected 3-amino-piperidine-1-carboxylic acid t-butyl ester (De Costa, B., et al. J. Med. Chem. 1992, 35, 4334-43) after four synthetic steps: i) MeI, n-BuLi, THF, -78 C. to rt; ii) H2 (1 atm), 10% Pd/C, EtOH; iii) AcCl, i-Pr2NEt, CH2Cl2; iv) CF3CO2H, CH2Cl2. m/z: [M+H]+calcd for C8H16N2O: 157.13; found, 157.2. 1H-NMR (CD3OD; TFA salt): delta (ppm) 4.6 (m, 1H), 3.3 (m, 1H), 3.2 (m, 1H), 3.0 (m, 1H), 2.9 (s, 3H), 2.8 (m, 1H), 2.0 (s, 3H), 1.9-1.7 (m, 4H)., 392331-89-4
The synthetic route of 392331-89-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; THERAVANCE, INC.; US2006/100426; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem