With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.387827-19-2,tert-Butyl 4-(3-aminophenyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
A dried flask, under argon atmosphere, was charged w[th Pd2(dba)3 (21 mg, 0.023mmo), 1,1Bs(diphenyphosphino)ferrocene (38 mg, 0.068 mmo), NaOtBu (44 mg,0455 mmo), tertbuty (126 mg, 0.455mmo) and 2bromo54uoropyridine (80 mg, 0.455 mmo). Degassed dry touene (4mL) was added and the mxture was heated at 80 C for 4.5 h, The reaction mixturewas cooed at rt, dichoromethane was added and fiftered through a pad of Ceite, Purification by flash chromatography, siNca ge, gradient hexane to ethy acetate afforded the desired product (127 mg, 75% yied). 1H-NMR (500MHz, CDC3) oe ppm:8.09 (m, 1H), 7.29 (m, 2H), 7.17 (m, 1H), 7.14 (m, 1H), 6.91 (m, 1H), 6.84 (m, 1H),6.53 (bs, 1H), 4.26 (m, 2H), 2.82 (m, 2H), 2.65 (m, 1H), 1.85 (m, 2H), 1.64 (m, 2H),1.45 (s, 9H).
The synthetic route of 387827-19-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; CUEVAS CORDOBES, Felix; ALMANSA-ROSALES, Carmen; GARCIA LOPEZ, Monica; WO2015/91939; (2015); A1;,
Piperidine – Wikipedia
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