37675-20-0, (R)-(Piperidin-3-yl)methanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 1: [(R)-1-(4-Bromo-8,9-dihydro-7H-6-oxa-2,9a-diazabenzo[cd]azulen-1-yl)piperidin-3-yl]methanol A mixture of 4-bromo-1-methanesulfonyl-8,9-dihydro-7H-6-oxa-2,9a-diazabenzo[cd]azulene (0.305 g, 0.92 mmol), (R)-1-piperidin-3-ylmethanol (0.212 g, 1.84 mmol) and N,N-diisopropylethylamine (0.319 mL, 1.84 mmol) in propan-2-ol (2.0 mL) was heated in a sealed vial at 150 C. under microwave irradiation for 17 hours. The reaction mixture was partitioned between ethyl acetate and aqueous sodium bicarbonate solution. The aqueous phase was further extracted with ethyl acetate and the combined organic extracts were washed with brine, dried over sodium sulfate, filtered and evaporated in vacuo. The residue was purified via flash chromatography on silica gel (solvent gradient: 25-100% ethyl acetate in toluene, then 50-100% methyl acetate in ethyl acetate) to yield 71 mg (21%) of the title compound as a white solid. LCMS (ESI): [M+H]+=366/368.
37675-20-0 (R)-(Piperidin-3-yl)methanol 853001, apiperidines compound, is more and more widely used in various.
Reference£º
Patent; Genentech, Inc.; Braun, Marie-Gabrielle; Garland, Keira; Hanan, Emily; Purkey, Hans; Staben, Steven T.; Heald, Robert Andrew; Knight, Jamie; Macleod, Calum; Lu, Aijun; Wu, Guosheng; Yeap, Siew Kuen; (183 pag.)US2018/65983; (2018); A1;,
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