With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3612-20-2,1-Benzylpiperidin-4-one,as a common compound, the synthetic route is as follows.
8-benzyl-1,3,8-triazaspiro[4.5]decane-2,4-dione1-Benzylpiperidin-4-one (49A) (20.0 g, 105.68 mmol)Soluble in ethanol (140mL), add potassium cyanide with stirring(14.3 g, 219.6 mmol) and water (140 mL),The mixture was stirred at 85 C for 36 hours.The reaction solution was cooled to room temperature, filtered, and the filter cake was washed with hot water (100 mL×3).The filter cake is dried to a white solid8-benzyl-1,3,8-triazaspiro[4.5]decane-2,4-dione (49B)(24.3 g, yield: 88.68%)., 3612-20-2
As the paragraph descriping shows that 3612-20-2 is playing an increasingly important role.
Reference：
Patent; Sichuan Hai Sike Pharmaceutical Co., Ltd.; Fan Jiang; Zhu Fengfei; Chen Qingping; Wang Chengtao; (251 pag.)CN109206417; (2019); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem