With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.281652-10-6,1-Boc-4,4-difluoropiperidine,as a common compound, the synthetic route is as follows.
Example A.13 Preparation of Intermediate (16).(tnfluoroacetate salt) TFA (2 mL, 26 mmol, 10 eq) was added under stirring to a solution of 1-N-boc- 4,4-difluoromethylpiperidine (0.53 g, 2.25 mmol) in DCM (8 mL), cooled with an icebath. The reaction mixture was allowed to warm at room temperature and stirred for additional 30 minutes. Solvent was removed at reduced pressure, affording 0.73 g (70% yield over two steps) of intermediate 16 as a TFA salt.
281652-10-6, As the paragraph descriping shows that 281652-10-6 is playing an increasingly important role.
Reference£º
Patent; AXXAM S.P.A.; PEVARELLO, Paolo; LOHMER, Stefan; LIBERATI, Chiara; SENECI, Pierfausto; PESENTI, Cristina; PRANDI, Adolfo; WO2015/118019; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem