236406-39-6, 8-Boc-2,8-Diazaspiro[4.5]decane is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of intermediate I-i 3a (445 mg, 1 .25 mmol) in anhydrous DCM(50 mL) was added R-29a: tert-butyl 2,8-diazaspiro[4.5]decane-8-carboxylate(200 mg, 0.833 mmol), Cu(OAc)2 (181 mg, 1.0 mmol), DMAP (22 mg, 0.167 mmol), Et3N (337 mg, 3.332 mmol) and 4A MS (0.8 g), then the mixture was stirred at room temperature for 3 hrs under 02 atmosphere. After LC-MS showed the starting material was consumed completely, then added water,filtered, the mixture was extracted with DCM, the organic layer was washed with brine, dried over anhydrous Na2504, concentrated to give the crude compound which was purified by Prep-TLC ( PE/ EtOAc = 1 .5:1 ) to give the pure intermediate I-131a (60 mg, 13% yield) as a yellow solid. ESI-MS (Mi-i):551 calc. for C30H42N604: 550.3., 236406-39-6
As the paragraph descriping shows that 236406-39-6 is playing an increasingly important role.
Reference£º
Patent; FUNDACION PARA LA INVESTIGACION MEDICA APLICADA; CUADRADO TEJEDOR, Maria Del Mar; FRANCO FERNANDEZ, Rafael; GARCIA OSTA, Ana Maria; OYARZABAL SANTAMARINA, Julen; RABAL GRACIA, Maria Obdulia; WO2014/131855; (2014); A1;,
Piperidine – Wikipedia
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