21319-53-9, 1-Benzylpiperidine-2-carboxylic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 5 1,3,4,11a-Tetrahydro-2H-benzo[b]quinolizin-11(6H)-one. The following is a modification of the procedure reported (Gonzalez Trigo, G.; Alvarez-Builla, J. An. Quim., Ser. C 1980, 76, 12). N-benzylpipecolinic acid (5.10 g, 20.0 mmol) was placed in a 500 mL flask. Polyphosphoric acid (200 g) was added. The mixture was heated in an oil bath gradually to 140 C. with stirring. It was stirred at 140 C. until the bubbling stopped, then cooled to room temperature and poured into ice. The mixture was neutralized with aqueous NaGH (40%) and extracted with ether (5*80 mL). The combined extracts were washed with brine, dried (Na2SO4) and concentrated in vacuo to give a red solid (3.08 g, 77%): m.p. 71-72 C. (benzene); 1H NMR (300 MHz) delta 8.02 (dd, J=7.8, 1.3 Hz, 1 H), 7.50 (td, J=7.3, 1.4 Hz, 1 H), 7.35 (t, J=7.6 Hz, 1 H), 7.23 (d, J=7.6 Hz, 1 H), 3.88 (d, J=15.2 Hz, H-6), 3.68 (d, J=14.9 Hz, H-6), 3.09 (br d, J=11.2 Hz, 1 H), 2.77 (br d, J=10.5 Hz, 1 H), 2.44 (m, 1 H), 2.35 (td, J=11.3, 3.5 Hz, 1 H), 1.90 (br d,J=12.5 Hz, 1 H), 1.32-1.76 (m, 4 H); 13C NMR (75 MHz) delta 195.87, 141.73, 133.53, 130.12, 127.34, 127.00, 126.17, 69.21, 57.14, 56.13, 26.66, 25.02, 23.81.
21319-53-9, 21319-53-9 1-Benzylpiperidine-2-carboxylic acid 2841641, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; American Biogenetic Sciences, Inc.; University College Dublin; US6436954; (2002); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem