With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.189333-49-1,3-Benzyl-3,9-diazaspiro[5.5]undecane,as a common compound, the synthetic route is as follows.
Example Bl a.; Preparation of final compound 1; A mixture of intermediate compound 3 (prepared according to Al.c) (0.02 mol), 3- (phenylmethyl)-3,9-diazaspiro-[5.5]-undecane (0.02 mol) and Ti(iPrO)4 (0.035 mol) in 1,2-dichloroethane (80 ml) was stirred at 50C for a overnight, then brought to room temperature under N2 flow. NaBH(OAc)3 (0.035 mol) was added portionwise. The mixture was stirred at room temperature for 8 hours and poured out on ice. K2C03 10% was added. The mixture was filtered over celite and washed with CH2C12. The filtrate was extracted with CH2Cl2. The organic layer was separated, dried (MgS04), filtered, and the solvent was evaporated. The residue (26 g) was purified by column chromatography over silica gel (eluent gradient: CH2Cl2/CH3OH/NH4OH 95/5/0.5 to 90/10/1; 20-45 mum). Three fractions were collected and the solvent was evaporated. Yield: 1.8 g of final’compound 1 (15 %).
189333-49-1, As the paragraph descriping shows that 189333-49-1 is playing an increasingly important role.
Reference：
Patent; JANSSEN PHARMACEUTICA N.V.; WO2005/97795; (2005); A1;,
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