With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.188869-05-8,tert-Butyl 3-bromo-4-oxopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
188869-05-8, General procedure: Enolate 4 (485 mg, 2.5 mmol) was stirred in EtOH (12 mL) with NH4OAc (578 mg, 7.5 mmol). After 5 min the solids had fully dissolved. At this point, chloroacetylaldehyde (50percent in H2O, 0.48 mL, 3.75 mmol) was added and the reaction was warmed to 80 ¡ãC for 1 h. Following cooling to room temperature, AcOH-H2O (4:1, 10 mL) was added and stirring was continued for 30 min. The volatiles were removed under vacuum and the residue was dissolved in CH2Cl2 and washed with H2O. The aqueous was extracted once with CH2Cl2, and the combined organics were dried over Na2SO4 and concentrated. The dark residue was purified by silica gel chromatography [heptane/EtOAc, 9:1-3:1] to give 2-formylpyrrole-3-carbonitrile (1) as an off-white solid, 153.5 mg, 51percent.
As the paragraph descriping shows that 188869-05-8 is playing an increasingly important role.
Reference£º
Article; Moss, Thomas A.; Nowak, Thorsten; Tetrahedron Letters; vol. 53; 24; (2012); p. 3056 – 3060;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem