163271-08-7, tert-Butyl (4-methylpiperidin-4-yl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A flask was charged with triphosgene (12.2 g, 41.1 mmol, 1.50 equiv), DCM (50 mL), l, l, l,3,3,3-hexafluoropropan-2-ol (20.6 g, 122 mmol, 4.50 equiv). N,N-diisopropylethylamine (17.6 g, 136 mmol, 5.00 equiv) was added dropwise at 0 C. The resulting solution was stirred for 2 h at 0 C. t-Butyl N-(4-methylpiperidin-4-yl)carbamate (5.84 g, 27.2 mmol, 1.00 equiv) was added. The resulting solution was stirred for 2 h at 0 C and quenched with water (100 mL), as described in Example 6, Step 4. The residue was chromatographed on a silica gel column to provide 4.90 g (44% yield) of l, l, l,3,3,3-hexafluoropropan-2-yl 4-((t-butoxycarbonyl)amino)-4- methylpiperidine-l-carboxylate as a yellow oil. LCMS (ESI, m/z): 409 [M+H]+.
163271-08-7, As the paragraph descriping shows that 163271-08-7 is playing an increasingly important role.
Reference£º
Patent; ABIDE THERAPEUTICS, INC.; GRICE, Cheryl A.; WEBER, Olivia D.; BUZARD, Daniel J.; SHAGHAFI, Michael B.; JONES, Todd K.; (275 pag.)WO2019/46318; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem