163271-08-7, tert-Butyl (4-methylpiperidin-4-yl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Methanesulfonyl chloride (0.18 ml_) was added to a solution of 3-[2-(3-{[tert- butyl(dimethyl)silyl]oxy}-2,2-dimethylpropyl)-4-(1 -hydroxyethyl)-1 -oxo-1 ,2- dihydroisoquinolin-6-yl]-Lambda/-cyclopropyl-5-fluoro-4-methylbenzamide (Example 41a, 1.1 g) and triethylamine (0.66 ml_) in DCM (9 ml_) at 0 0C. The solution (total volume 11 mL) was stirred for 10 min and then 1 h at room temperature to afford a stock solution (11 mL). Aliquots of this were used directly without further purification to prepare examples 41 – 45.A solution of terf-butyl (4-methylpiperidin-4-yl)carbamate (74 mg) in DCM (1 mL) was added to a 1 mL aliquot of the above stock solution and the reaction stirred for 20 h. 4 M HCI in dioxane (1 mL) was added and the reaction allowed to stir for a further 20 h. The volatiles were removed in vacuo and the crude material was dissolved in methanol (2 mL) and loaded onto a 10 g SCX cartridge. The impurities were washed through with methanol (75 mL) and discarded. The product was eluted with 1 N methanolic ammonia (75 mL) and evaporated in vacuo. Purification by preparative HPLC (Gemini-NX C18 column using a 95-5 % gradient of aqueous 0.1 % ammonia in methanol as eluent) afforded the title product (10 mg) as a solid. MS: APCI(+ve) 563 (M+H)+ 1H NMR delta (DMSO-Cl6) 8.52 (d, 1H)1 8.36 (d, 1H), 8.17 (s, 1H), 7.68 – 7.64 (m, 2H), 7.53 (dd, 1 H), 7.34 (s, 1H), 4.89 (t, 1H), 4.10 (s, 1 H), 3.94 (dd, 2H), 3.84 (q, 1 H), 3.32 (s, 4H), 3.17 (s, 1 H), 3.11 (d, 2H), 2.85 (sextet, 1H), 2.60 – 2.32 (m, 4H), 2.23 (d, 3H), 1.33 (d, 3H), s 0.98 (s, 3H), 0.87 (s, 6H), 0.69 (td, 2H), 0.58 – 0.54 (m, 2H)
163271-08-7, As the paragraph descriping shows that 163271-08-7 is playing an increasingly important role.
Reference£º
Patent; ASTRAZENECA AB; BROUGH, Stephen, John; LUKER, Timothy, Jon; ROBERTS, Bryan, Glyn; ST-GALLAY, Stephen, Anthony; WO2010/39079; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem