With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.142752-12-3,1-(4-Aminophenyl)piperidin-4-ol,as a common compound, the synthetic route is as follows.
A mixture of starting material (12 mg, 0.05 mmol), 1-(4-aminophenyl)piperidin-4-ol (10 mg, 0.05 mmol), X-Phos (4.3 mg), Pd2(dba)3 (5.5 mg) and K2CO3 (30 mg, 0.22 mmol) in t-BuOH (1.0 mL) was heated at 85 C. in a seal tube for 4 h. The reaction was then filtered through celite, eluted with dichloromethane, and concentrated in vacuo. The residue was then purified by reverse-phase prep-HPLC to afford the title compound as the TFA salt (8.2 mg, 40%).
142752-12-3, As the paragraph descriping shows that 142752-12-3 is playing an increasingly important role.
Reference£º
Patent; DANA-FARBER CANCER INSTITUTE, INC.; Gray, Nathanael S.; Waller, David; Choi, Hwan Guen; Wang, Jinhua; Deng, Xianming; (104 pag.)US2016/24115; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem