140645-24-5, (S)-3-(Aminomethyl)-1-N-Boc-piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 3 (3.4 g, 20 mmol) in DMF (34 mL), (3S)-3-(aminomethyl)piperidine-1-carboxylic acid tert-butyl ester (5.2 g, 24 mmol) and DIPEA (4.5 mL, 26 mmol) were added. The reaction mixture was stirred at room temperature for 14 h. The reaction mixture was poured into saturated aqueous NH4Cl and extracted with EtOAc. The organic layer was washed with H2O and brine and then dried over Na2SO4 and concentrated in vacuo to give a brown solid. To a solution of the residue in CH2Cl2 (60 mL), TFA (13 mL, 170 mmol) was added and stirred at room temperature for 4 h. The reaction mixture was concentrated in vacuo. The residue was added to saturated aqueous K2CO3 and extracted with (CHCl3-MeOH) (80:20). The organic layer was dried over Na2SO4 and concentrated in vacuo to give 12 (4.2 g, 87%) as a pale solid, 140645-24-5
The synthetic route of 140645-24-5 has been constantly updated, and we look forward to future research findings.
Reference：
Article; Kunikawa, Shigeki; Tanaka, Akira; Mukoyoshi, Koichiro; Nagashima, Shinya; Tominaga, Hiroaki; Chida, Noboru; Tasaki, Mamoru; Shirai, Fumiyuki; Bioorganic and Medicinal Chemistry; vol. 23; 13; (2015); p. 3269 – 3277;,
Piperidine – Wikipedia
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