1187173-43-8, 2,7-Diazaspiro[4.5]decan-1-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
2,7-Diazaspiro[4.5]decan-1 -one hydrogen chloride (430 mg, 2.255 mmol) was dissolved in dichloromethane (4 mL), and triethylamine (0.628 mL, 4.53 mmol) was added followed by 2-bromo-4-(trifluoromethyl)benzenesulfonyl chloride (804 mg, 2.484 mmol). After stirring for 20 h the reaction mixture was concentrated in vacuo. The resulting residue was redissolved in EtOAc, washed with aqueous 1 M HCI followed by washing by saturated aqueous Na2C03. The organic layer was passed through a hydrophobic frit, concentrated in vacuo and recrystallised from methanol to give 7-{[2-bromo-4-(trifluoromethyl)phenyl]sulfonyl}-2,7-diazaspiro[4.5]decan-1 -one (395 mg, 0.877 mmol, 38% yield). The mother liquor was concentrated in vacuo to give the following impure material: 7-{[2-bromo-4-(trifluoromethyl)phenyl]sulfonyl}- 2,7-diazaspiro[4.5]decan-1 -one (419 mg, 0.548 mmol, 57.7% purity by mass, 24% yield), a mixture of desired product and 2-bromo-4-(trifluoromethyl)benzenesulfonyl chloride (1 :1 by molar equivalence). 1 H NMR (400 MHz, DMSO-c/6) delta ppm 1.46 – 1 .63 (m, 3 H) 1.65 – 1.74 (m, 1 H) 1.87 – 1.99 (m, 2 H) 2.74 – 2.80 (m, 1 H) 2.83 (d, J=12.50 Hz, 1 H) 3.05 – 3.20 (m, 2 H) 3.43 (d, J=12.39 Hz, 1 H) 3.72 (d, J=1 1.40 Hz, 1 H) 7.74 (s, 1 H) 7.97 (dd, J=8.28, 1.21 Hz, 1 H) 8.18 (d, J=8.00 Hz, 1 H) 8.29 (d, J=1.15 Hz, 1 H). MS ES+ve m/z 441 (M+H)., 1187173-43-8
The synthetic route of 1187173-43-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; CONVERGENCE PHARMACEUTICALS LIMITED; GLEAVE, Robert James; HACHISU, Shuji; PAGE, Lee William; BESWICK, Paul John; WO2011/141728; (2011); A1;,
Piperidine – Wikipedia
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